scPDB - Distribution of Binding site Similarity values of 4xz3 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4xz3	COA	Acyl-CoA synthetase (NDP forming)

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4xz3	COA	Acyl-CoA synthetase (NDP forming)	/	1.000
4xym	COA	Acyl-CoA synthetase (NDP forming)	/	0.625
5hbr	COA	Acyl-CoA synthetase (NDP forming)	/	0.561
1fm4	DXC	Major pollen allergen Bet v 1-L	/	0.504
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.486
1zdw	FLV	Prenyltransferase	/	0.471
2fhj	H4Z	Formylmethanofuran--tetrahydromethanopterin formyltransferase	2.3.1.101	0.467
2hrc	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.467
2v4l	ABJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.467
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.464
1d2s	DHT	Sex hormone-binding globulin	/	0.463
1gpe	FAD	Glucose oxidase	1.1.3.4	0.461
4a80	2AN	Major pollen allergen Bet v 1-A	/	0.461
4fhk	0U0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.461
2qd3	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.459
2qd4	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.459
4yak	ACO	Acyl-CoA synthetase (NDP forming)	/	0.459
1o9b	NAI	Quinate/shikimate dehydrogenase	/	0.458
1yrd	CAM	Camphor 5-monooxygenase	1.14.15.1	0.458
2ibz	UQ6	Cytochrome b	/	0.458
2ea4	F79	Methionine aminopeptidase 2	/	0.457
2ji9	TPW	Oxalyl-CoA decarboxylase	4.1.1.8	0.457
4a87	NAR	Major pollen allergen Bet v 1-A	/	0.456
4a8v	2AN	Major pollen allergen Bet v 1-J	/	0.456
4gl4	NAI	Alcohol dehydrogenase class-3	/	0.454
1ezv	UQ6	Cytochrome b	/	0.453
3apw	DP0	Alpha-1-acid glycoprotein 2	/	0.453
4jlt	8PR	Cytochrome P450 2B4	1.14.14.1	0.453
4y8w	STR	Steroid 21-hydroxylase	/	0.453
4m83	ERY	Oleandomycin glycosyltransferase	2.4.1	0.452
4n6h	EJ4	Delta-type opioid receptor	/	0.452
4rri	A3T	Probable threonine--tRNA ligase 2	6.1.1.3	0.452
1e8x	ATP	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.451
2c9d	PHR	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.451
2g1s	4IG	Renin	3.4.23.15	0.451
2pnj	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.451
2cy0	NAP	Shikimate dehydrogenase (NADP(+))	/	0.450
4ek1	CAM	Camphor 5-monooxygenase	1.14.15.1	0.450
4j03	FVS	Bifunctional epoxide hydrolase 2	3.1.3.76	0.450
1dz8	CAM	Camphor 5-monooxygenase	1.14.15.1	0.449
3oqk	S52	Renin	3.4.23.15	0.449
3tk3	CPZ	Cytochrome P450 2B4	1.14.14.1	0.449
4a83	DXC	Major pollen allergen Bet v 1-A	/	0.449
4rvg	TYD	D-mycarose 3-C-methyltransferase	/	0.449
1cul	FOK	Adenylate cyclase type 2	/	0.448
1cul	FOK	Adenylate cyclase type 5	/	0.448
2v58	LZJ	Biotin carboxylase	6.3.4.14	0.448
3gwf	NAP	Cyclohexanone monooxygenase	/	0.448
3ibd	CPZ	Cytochrome P450 2B6	1.14.13	0.448
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.448
4jvf	17X	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	/	0.448
1zga	HMK	Isoflavone 4'-O-methyltransferase	/	0.447
2xc3	RT8	Steroid C26-monooxygenase	1.14.13.141	0.447
2zba	ZBA	Trichothecene 3-O-acetyltransferase	/	0.447
1vi2	NAD	Quinate/shikimate dehydrogenase	/	0.446
2rhr	EMO	Putative ketoacyl reductase	1.3.1	0.446
3opd	HIE	Heat shock protein 83	/	0.446
4g09	0VD	Histidinol dehydrogenase	/	0.446
4yak	COA	Acyl-CoA synthetase (NDP forming)	/	0.446
4zj8	SUV	Orexin receptor type 1	/	0.446
1t32	OHH	Cathepsin G	3.4.21.20	0.445
3l6j	Z90	Alr2278 protein	/	0.445
4hnc	0UT	Mandelate racemase	/	0.445
4rww	2BA	Lmo2692 protein	/	0.445
4xr9	NAD	CalS8	/	0.445
1d7a	AIR	N5-carboxyaminoimidazole ribonucleotide mutase	/	0.444
1tsd	F89	Thymidylate synthase	/	0.444
1zg3	2HI	Isoflavone 4'-O-methyltransferase	/	0.444
2oeg	UPG	UDP-glucose pyrophosphorylase	/	0.444
3zbz	OVE	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.444
1fmj	RTL	Retinol dehydratase	/	0.443
1soj	IBM	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.443
2hl1	A3S	Threonine--tRNA ligase	6.1.1.3	0.443
3jyp	NAD	Quinate/shikimate dehydrogenase (NAD(+))	/	0.443
1e7v	LY2	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.442
1wp4	NDP	3-hydroxyisobutyrate dehydrogenase	/	0.442
2dvl	FAD	Acyl-CoA dehydrogenase	/	0.442
2x8i	X8I	Serine/threonine-protein kinase Chk1	2.7.11.1	0.442
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.442
1so2	666	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.441
2iod	MYC	Dihydroflavonol 4-reductase	1.1.1.219	0.441
2jfa	RAL	Estrogen receptor	/	0.441
2o1s	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.441
2o98	FSC	14-3-3-like protein C	/	0.441
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.441
3jun	AKD	Phenazine biosynthesis protein A/B	/	0.441
4j8t	DOG	Uncharacterized PhzA/B-like protein PA3332	/	0.441
1cjk	FOK	Adenylate cyclase type 2	/	0.440
1cjk	FOK	Adenylate cyclase type 5	/	0.440
1dv2	ATP	Biotin carboxylase	6.3.4.14	0.440
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.440
1qk3	5GP	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	2.4.2.22	0.440
1xdd	AAY	Integrin alpha-L	/	0.440
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.440
3r7k	FDA	Probable acyl CoA dehydrogenase	/	0.440
3wrh	CAM	Camphor 5-monooxygenase	1.14.15.1	0.440
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.440
4pkw	GM6	Lethal factor	3.4.24.83	0.440
5dqr	FAD	7-hydroxymethyl chlorophyll a reductase, chloroplastic	1.17.7.2	0.440
4s0v	SUV	Orexin receptor type 2	/	0.440