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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4xc0ACPHeat shock cognate 90 kDa protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4xc0ACPHeat shock cognate 90 kDa protein/1.000
1yszNECEndoplasmin/0.535
3ekrPY9Heat shock protein HSP 90-alpha/0.531
4bqjXKLHeat shock protein HSP 90-alpha/0.531
3rlq3RQHeat shock protein HSP 90-alpha/0.519
2xcmADPCytosolic heat shock protein 90/0.516
2gfdRDAEndoplasmin/0.515
4xclAGSHeat shock cognate 90 kDa protein/0.512
1y4sADPChaperone protein HtpG/0.510
4fcr0TMHeat shock protein HSP 90-alpha/0.508
4xcjADPHeat shock cognate 90 kDa protein/0.508
2qg0A94Heat shock protein HSP 90-alpha/0.507
2hchN5AEndoplasmin/0.504
4ipeANPTNF receptor-associated protein 1/0.499
2wepADPATP-dependent molecular chaperone HSP82/0.495
1u0yPA7Endoplasmin/0.494
1u2oNECEndoplasmin/0.494
2yefANPHeat shock protein HSP 90-alpha/0.494
1byqADPHeat shock protein HSP 90-alpha/0.493
2gqpPA7Endoplasmin/0.491
1qy5NECEndoplasmin/0.484
2byh2D7Heat shock protein HSP 90-alpha/0.482
3t10ACPHeat shock protein HSP 90-alpha/0.482
1yc34BCHeat shock protein HSP 90-alpha/0.481
2byi2DDHeat shock protein HSP 90-alpha/0.481
3k974CDHeat shock protein HSP 90-alpha/0.479
3hekBD0Heat shock protein HSP 90-alpha/0.478
1am1ADPATP-dependent molecular chaperone HSP82/0.477
3c11GDMATP-dependent molecular chaperone HSP82/0.477
1qy8RDIEndoplasmin/0.475
3r4pFU7Heat shock protein HSP 90-alpha/0.472
3rlr3RRHeat shock protein HSP 90-alpha/0.472
3hhu819Heat shock protein HSP 90-alpha/0.471
4ivgANPTNF receptor-associated protein 1/0.471
4ce17FKATP-dependent molecular chaperone HSP82/0.469
1uymPU3Heat shock protein HSP 90-beta/0.468
1g1aNADdTDP-glucose 4,6-dehydratase/0.467
2bt0CT5Heat shock protein HSP 90-alpha/0.467
2hg1N5OEndoplasmin/0.467
2breKJ2ATP-dependent molecular chaperone HSP82/0.466
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.466
1yc14BCHeat shock protein HSP 90-alpha/0.465
2vw5BC6ATP-dependent molecular chaperone HSP82/0.465
2wi6ZZ6Heat shock protein HSP 90-alpha/0.465
3whaWHAHeat shock protein HSP 90-alpha/0.464
4jqlVJ6Heat shock protein HSP 90-alpha/0.464
4xdmGDMHeat shock cognate 90 kDa protein/0.462
2bz5AB4Heat shock protein HSP 90-alpha/0.461
2xx213CATP-dependent molecular chaperone HSP82/0.461
3t2sAGSHeat shock protein HSP 90-alpha/0.460
3hyz42CHeat shock protein HSP 90-alpha/0.458
4gqtADPHeat shock protein 90/0.455
3t0zATPHeat shock protein HSP 90-alpha/0.454
3t1kANPHeat shock protein HSP 90-alpha/0.453
3qrwNDPPutative ketoacyl reductase1.3.10.451
2exlGDMEndoplasmin/0.450
2xk2ADPHeat shock protein HSP 90-alpha/0.447
1u0zRDCEndoplasmin/0.444
2bu8ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.443
2werRDCATP-dependent molecular chaperone HSP82/0.443
1uy8PU5Heat shock protein HSP 90-alpha/0.442
2xhrC0PHeat shock protein HSP 90-alpha/0.442
2xhtC0YHeat shock protein HSP 90-alpha/0.442
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.442
3ft8MOJHeat shock protein HSP 90-alpha/0.442
1uy7PU4Heat shock protein HSP 90-alpha/0.441
2yegXQGHeat shock protein HSP 90-alpha/0.441
3pjuC2EDiguanylate cyclase/phosphodiesterase/0.441
2iwuNP5ATP-dependent molecular chaperone HSP82/0.440
4ce3L4VATP-dependent molecular chaperone HSP82/0.440