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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ux9ANPMitogen-activated protein kinase 82.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ux9ANPMitogen-activated protein kinase 82.7.11.241.000
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.557
2xrwANPMitogen-activated protein kinase 82.7.11.240.533
1pmn984Mitogen-activated protein kinase 102.7.11.240.531
3kvxFMYMitogen-activated protein kinase 102.7.11.240.526
2p33J07Mitogen-activated protein kinase 102.7.11.240.521
1jnkANPMitogen-activated protein kinase 102.7.11.240.515
4btjADPTau-tubulin kinase 12.7.11.10.507
3eljGS7Mitogen-activated protein kinase 82.7.11.240.505
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.503
1dawANPCasein kinase II subunit alpha2.7.11.10.492
3cgfJNFMitogen-activated protein kinase 102.7.11.240.492
3i60E86Mitogen-activated protein kinase 12.7.11.240.491
4lfiGNPCasein kinase II subunit alpha2.7.11.10.489
2xs0ANPMitogen-activated protein kinase 82.7.11.240.487
4qnyANPMitogen activated protein kinase, putative/0.487
4btjATPTau-tubulin kinase 12.7.11.10.484
1dayGNPCasein kinase II subunit alpha2.7.11.10.482
3ttjJBIMitogen-activated protein kinase 102.7.11.240.481
4aqc88ATyrosine-protein kinase JAK2/0.480
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.480
2pvnP63Casein kinase II subunit alpha2.7.11.10.479
4deeADPAurora kinase A2.7.11.10.479
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.478
2zdt46CMitogen-activated protein kinase 102.7.11.240.477
4anmWULCasein kinase II subunit alpha2.7.11.10.477
4fv6E57Mitogen-activated protein kinase 12.7.11.240.476
1i44ACPInsulin receptor2.7.10.10.475
4j95ACPFibroblast growth factor receptor 2/0.475
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.474
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
3gxlQIGTGF-beta receptor type-12.7.11.300.470
2excJNKMitogen-activated protein kinase 102.7.11.240.469
3be9P04Casein kinase II subunit alpha2.7.11.10.469
5dnrATPAurora kinase A2.7.11.10.469
4g1wG1WMitogen-activated protein kinase 82.7.11.240.467
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.465
4jboWPHAurora kinase A2.7.11.10.465
3hmm855TGF-beta receptor type-12.7.11.300.463
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.463
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.461
3gu7ADPDeath-associated protein kinase 12.7.11.10.461
5dosATPAurora kinase A2.7.11.10.460
5e8ySTUTGF-beta receptor type-22.7.11.300.459
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.458
2ijmATPFocal adhesion kinase 12.7.10.20.458
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.458
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.458
3ttiKBIMitogen-activated protein kinase 102.7.11.240.457
4hge15VTyrosine-protein kinase JAK2/0.457
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4k33ACPFibroblast growth factor receptor 32.7.10.10.457
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.456
4jia1K3Tyrosine-protein kinase JAK2/0.456
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.455
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.455
3fi3JK2Mitogen-activated protein kinase 102.7.11.240.455
3oroAGSSerine/threonine protein kinase/0.455
2w05FRTCyclin-dependent kinase 22.7.11.220.454
3dfcANPDeath-associated protein kinase 12.7.11.10.454
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.453
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.451
1m2pHNACasein kinase II subunit alpha2.7.11.10.451
5cvfATPCasein kinase II subunit alpha2.7.11.10.451
1ipeNDPTropinone reductase 21.1.1.2360.450
2yaaATPDeath-associated protein kinase 2/0.450
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.449
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.449
4h3qANPMitogen-activated protein kinase 12.7.11.240.449
4jbpYPHAurora kinase A2.7.11.10.449
4o1pANPRibonuclease L/0.449
3cgoJNOMitogen-activated protein kinase 102.7.11.240.448
3nieANPMitogen-activated protein kinase/0.448
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.448
4wsqKSAAP2-associated protein kinase 12.7.11.10.448
3efwAK8Aurora kinase A2.7.11.10.447
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.447
4hvi19STyrosine-protein kinase JAK32.7.10.20.447
4jqeANPCasein kinase II subunit alpha2.7.11.10.447
1bygSTUTyrosine-protein kinase CSK/0.446
1eh4IC1Casein kinase I homolog 12.7.11.10.445
1oaaNAPSepiapterin reductase1.1.1.1530.445
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.445
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2j0lANPFocal adhesion kinase 12.7.10.20.444
2pvhP19Casein kinase II subunit alpha2.7.11.10.444
2pvlP55Casein kinase II subunit alpha2.7.11.10.444
2zdu446Mitogen-activated protein kinase 102.7.11.240.444
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.444
3oriAGSSerine/threonine protein kinase/0.444
4dgnLU2Casein kinase II subunit alpha2.7.11.10.444
5awmANPStress-activated protein kinase JNK2.7.11.240.444
1aq1STUCyclin-dependent kinase 22.7.11.220.443
3iok1P6Tyrosine-protein kinase JAK2/0.443
3lpbNVBTyrosine-protein kinase JAK2/0.443
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.443
3mtfA3FActivin receptor type-12.7.11.300.442
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.442
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.442
1g5sI17Cyclin-dependent kinase 22.7.11.220.441
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.440
3ormAGSSerine/threonine protein kinase/0.440