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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4nka2K7Fibroblast growth factor receptor 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4nka2K7Fibroblast growth factor receptor 1/1.000
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.554
4nks2M2Fibroblast growth factor receptor 1/0.543
2fgiPD1Fibroblast growth factor receptor 1/0.534
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.534
2c6eHPMAurora kinase A2.7.11.10.532
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.528
4f640S8Fibroblast growth factor receptor 1/0.525
4nk92K5Fibroblast growth factor receptor 1/0.524
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.521
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.513
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.512
3s4qNK0Mitogen-activated protein kinase 14/0.507
3l8p0CEAngiopoietin-1 receptor2.7.10.10.499
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.498
4j97ACPFibroblast growth factor receptor 2/0.498
3js2VM1Fibroblast growth factor receptor 1/0.497
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.493
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.490
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.487
1zyjBI5Mitogen-activated protein kinase 14/0.487
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.486
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.486
2v7a627Tyrosine-protein kinase ABL12.7.10.20.485
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.485
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.484
3uvqFS8Mitogen-activated protein kinase 14/0.482
4hvh19RTyrosine-protein kinase JAK32.7.10.20.481
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.480
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.480
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.479
4gmy0X5Tyrosine-protein kinase JAK2/0.479
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.476
3mvl38PMitogen-activated protein kinase 14/0.475
3w2sW2REpidermal growth factor receptor2.7.10.10.474
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.473
3gubGUBDeath-associated protein kinase 12.7.11.10.473
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.473
4f630S7Fibroblast growth factor receptor 1/0.471
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
3vryB43Tyrosine-protein kinase HCK2.7.10.20.470
4id71G0Activated CDC42 kinase 1/0.470
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.469
2hk51BMTyrosine-protein kinase HCK2.7.10.20.468
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.468
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.467
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.467
2i0ePDSProtein kinase C beta type2.7.11.130.466
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.466
4eym0RXMitogen-activated protein kinase 132.7.11.240.465
2itzIREEpidermal growth factor receptor2.7.10.10.464
3gfeP37Mitogen-activated protein kinase 14/0.464
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.464
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
2j7t274Serine/threonine-protein kinase 102.7.11.10.463
3vs3VSETyrosine-protein kinase HCK2.7.10.20.463
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.463
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.463
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.463
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.462
4jia1K3Tyrosine-protein kinase JAK2/0.462
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.460
2hog710Serine/threonine-protein kinase Chk12.7.11.10.460
4eevL1XHepatocyte growth factor receptor2.7.10.10.460
4hvi19STyrosine-protein kinase JAK32.7.10.20.460
1bygSTUTyrosine-protein kinase CSK/0.459
3zewSTUEphrin type-B receptor 42.7.10.10.459
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.459
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.458
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.457
4gk4L90Ephrin type-A receptor 32.7.10.10.457
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.456
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.456
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.456
3w2rW2REpidermal growth factor receptor2.7.10.10.456
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.456
1m17AQ4Epidermal growth factor receptor2.7.10.10.455
1pmn984Mitogen-activated protein kinase 102.7.11.240.455
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.455
1yvj4STTyrosine-protein kinase JAK32.7.10.20.455
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.455
3dt1P40Mitogen-activated protein kinase 14/0.455
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.455
4i22IREEpidermal growth factor receptor2.7.10.10.455
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.454
2vrx447Aurora kinase B-A2.7.11.10.453
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.453
4aotGW8Serine/threonine-protein kinase 102.7.11.10.453
4e4m0NHTyrosine-protein kinase JAK2/0.453
4ic7ANPMitogen-activated protein kinase 72.7.11.240.453
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.453
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2h96893Mitogen-activated protein kinase 82.7.11.240.452
4anqVGHALK tyrosine kinase receptor2.7.10.10.452
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.452
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.452
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.452
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.451
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.451
4c4h7RODual specificity protein kinase TTK2.7.12.10.451
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.451
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.451
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.450
3gc9B45Mitogen-activated protein kinase 112.7.11.240.450
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.450
4c4g7RODual specificity protein kinase TTK2.7.12.10.450
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.450
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.449
3ds6A17Mitogen-activated protein kinase 14/0.449
3uvp048Mitogen-activated protein kinase 14/0.449
4hvg19QTyrosine-protein kinase JAK32.7.10.20.448
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.447
3ttiKBIMitogen-activated protein kinase 102.7.11.240.447
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.447
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.447
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.446
3w33W19Epidermal growth factor receptor2.7.10.10.446
1agwSU2Fibroblast growth factor receptor 1/0.445
2of4979Tyrosine-protein kinase Lck2.7.10.20.445
2zybKSLTyrosine-protein kinase Lck2.7.10.20.445
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.445
3ttjJBIMitogen-activated protein kinase 102.7.11.240.445
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.445
3vjoANPEpidermal growth factor receptor2.7.10.10.445
1xkkFMMEpidermal growth factor receptor2.7.10.10.444
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.444
2py3ACPFibroblast growth factor receptor 2/0.444
3ctj320Hepatocyte growth factor receptor2.7.10.10.444
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
4jr3KJREpidermal growth factor receptor2.7.10.10.444
2c7xNRBCytochrome P450 monooxygenase PikC/0.443
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.443
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.442
2pvyACPFibroblast growth factor receptor 2/0.442
2xp2VGHALK tyrosine kinase receptor2.7.10.10.442
3iphG11Mitogen-activated protein kinase 14/0.442
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.442
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.442
5aaaVGHALK tyrosine kinase receptor2.7.10.10.442
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.441
3fklFKLMitogen-activated protein kinase 14/0.441
4c4f7CEDual specificity protein kinase TTK2.7.12.10.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
4jbqVX6Aurora kinase A2.7.11.10.441
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.441
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.441
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.440
1oecAA2Fibroblast growth factor receptor 2/0.440
2j0m4STFocal adhesion kinase 12.7.10.20.440
2pzpACPFibroblast growth factor receptor 2/0.440
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.440
4fnyI3KALK tyrosine kinase receptor2.7.10.10.440
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.440