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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4mr61K0Bromodomain-containing protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4mr61K0Bromodomain-containing protein 2/1.000
4uyg73BBromodomain-containing protein 2/0.599
4j1p1K0Bromodomain-containing protein 2/0.591
4mr51K0Bromodomain-containing protein 2/0.566
2yekEAMBromodomain-containing protein 2/0.555
2yemWSHBromodomain-containing protein 4/0.543
5bt52LOBromodomain-containing protein 2/0.541
4uyf73BBromodomain-containing protein 2/0.531
4flpJQ1Bromodomain testis-specific protein/0.525
4o701QKBromodomain-containing protein 4/0.519
4alhA9PBromodomain-containing protein 2/0.517
4a9oA9OBromodomain-containing protein 2/0.513
4men25KBromodomain-containing protein 4/0.509
4c67L5SBromodomain-containing protein 4/0.506
4ogiR78Bromodomain-containing protein 4/0.502
4o71CPBBromodomain-containing protein 4/0.501
4aknS5BBromodomain-containing protein 2/0.500
4py6R78Bromodomain protein, putative/0.500
4mep24YBromodomain-containing protein 4/0.499
4a9iP9IBromodomain-containing protein 2/0.495
4c66H4CBromodomain-containing protein 4/0.491
4bjx73BBromodomain-containing protein 4/0.490
2ydwWSHBromodomain-containing protein 2/0.488
4a9nA9NBromodomain-containing protein 2/0.487
4j0r1H2Bromodomain-containing protein 4/0.487
4lrg1XBBromodomain-containing protein 4/0.487
4o761M3Bromodomain-containing protein 4/0.487
3vt7VDXVitamin D3 receptor/0.485
4hxs1A3Bromodomain-containing protein 4/0.484
4lyw21QBromodomain-containing protein 4/0.484
3aqaBYHBromodomain-containing protein 2/0.483
4mr41K0Bromodomain-containing protein 4/0.481
4lr61XABromodomain-containing protein 4/0.480
4o74R78Bromodomain-containing protein 4/0.480
4bw1S5BBromodomain-containing protein 4/0.479
4h4m494Gag-Pol polyprotein2.7.7.490.474
4qzsJQ1Bromodomain-containing protein 4/0.474
4nr52LLCREB-binding protein/0.473
4a9e3PFBromodomain-containing protein 2/0.472
4bw2UTHBromodomain-containing protein 4/0.472
4nqmY1ZBromodomain-containing protein 4/0.472
4j0s1H3Bromodomain-containing protein 4/0.471
1x8lOXRRetinol dehydratase/0.468
4a9hTVPBromodomain-containing protein 2/0.468
4a9mP9MBromodomain-containing protein 2/0.467
4g1y0VOVitamin D3 receptor A/0.465
3fu83DMLaccase-11.10.3.20.464
4hxo1A6Bromodomain-containing protein 4/0.464
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
3vt9YI4Vitamin D3 receptor/0.462
3a1l2CCCytochrome P450/0.461
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.459
3s7a684Dihydrofolate reductase1.5.1.30.459
3u8hBHPPhospholipase A2, membrane associated/0.459
4o78SAVBromodomain-containing protein 4/0.458
3sf6FDAGlutaryl-CoA dehydrogenase/0.457
4a9lP9LBromodomain-containing protein 4/0.456
4f3i0S6Bromodomain-containing protein 4/0.456
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.455
3slkNDPPolyketide synthase extender module 2/0.455
4nyv15ECREB-binding protein/0.455
2hw2RFPRifampin ADP-ribosyl transferase/0.454
4mfb29TGag-Pol polyprotein2.7.7.490.454
4hbw14ZBromodomain-containing protein 4/0.453
2wonZZEGag-Pol polyprotein2.7.7.490.452
3w0hW12Vitamin D3 receptor/0.452
4e960NSBromodomain-containing protein 4/0.451
2hcdBIVVitamin D3 receptor A/0.450
3tamM06Gag-Pol polyprotein2.7.7.490.450
3vtcTK3Vitamin D3 receptor/0.450
1aiqCB3Thymidylate synthase/0.449
1fmlRTLRetinol dehydratase/0.449
1uy8PU5Heat shock protein HSP 90-alpha/0.449
3bw4FMNPutative 2-nitropropane dioxygenase/0.449
3lu8IQXSerum albumin/0.449
3r8zZ63Cyclin-dependent kinase 22.7.11.220.449
3vtdTKDVitamin D3 receptor/0.449
1cf3FADGlucose oxidase1.1.3.40.448
3c6tM14Gag-Pol polyprotein2.7.7.490.448
3c6uM22Gag-Pol polyprotein2.7.7.490.448
3oqfS51Renin3.4.23.150.448
3w5p4OAVitamin D3 receptor/0.448
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4iteTEYVitamin D3 receptor/0.446
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.445
3r9dX6BCyclin-dependent kinase 22.7.11.220.445
4rw6494Gag-Pol polyprotein2.7.7.490.445
1mczRMNBenzoylformate decarboxylase4.1.1.70.444
1poxFADPyruvate oxidase1.2.3.30.444
2b5j3ACGag-Pol polyprotein2.7.7.490.444
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3mdvCL6Cholesterol 24-hydroxylase/0.444
3vruYS3Vitamin D3 receptor/0.444
3zyu1GHBromodomain-containing protein 4/0.444
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
1ie8KH1Vitamin D3 receptor/0.443
1powFADPyruvate oxidase1.2.3.30.443
1r2jFADFkbI/0.443
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.443
3dokGWJPol protein/0.443
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4ib4ERM5-hydroxytryptamine receptor 2B/0.443
4j3i1K0Bromodomain-containing protein 4/0.443
3s1dZIRCytokinin dehydrogenase 11.5.99.120.442
4ia3BIVVitamin D3 receptor A/0.442
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1ppjANYCytochrome b/0.441
4eos1ROCyclin-dependent kinase 22.7.11.220.441
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1s19MC9Vitamin D3 receptor/0.440
4ia1BIVVitamin D3 receptor A/0.440
4iarERM5-hydroxytryptamine receptor 1B/0.440
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440