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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kip1R9Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kip1R9Mitogen-activated protein kinase 14/1.000
3fklFKLMitogen-activated protein kinase 14/0.634
4aa4QC0Mitogen-activated protein kinase 14/0.616
3iphG11Mitogen-activated protein kinase 14/0.606
3nww3NWMitogen-activated protein kinase 14/0.597
4aacAAVMitogen-activated protein kinase 14/0.593
3fskRO6Mitogen-activated protein kinase 14/0.583
2rg5279Mitogen-activated protein kinase 14/0.581
3dt1P40Mitogen-activated protein kinase 14/0.579
4kiq1RAMitogen-activated protein kinase 14/0.579
4kin1M8Mitogen-activated protein kinase 14/0.567
3fln3FNMitogen-activated protein kinase 14/0.561
3flzFLZMitogen-activated protein kinase 14/0.557
3mpt1GKMitogen-activated protein kinase 14/0.555
3s4qNK0Mitogen-activated protein kinase 14/0.554
3l8xN4DMitogen-activated protein kinase 14/0.553
4aa5NQBMitogen-activated protein kinase 14/0.553
2rg6287Mitogen-activated protein kinase 14/0.552
3ocgOCGMitogen-activated protein kinase 14/0.548
3fi4FI4Mitogen-activated protein kinase 14/0.543
2balPQAMitogen-activated protein kinase 14/0.541
3flyFLYMitogen-activated protein kinase 14/0.541
3flwFLWMitogen-activated protein kinase 14/0.539
3hl7I47Mitogen-activated protein kinase 14/0.538
3fmh533Mitogen-activated protein kinase 14/0.533
3mvm39PMitogen-activated protein kinase 14/0.523
3mvl38PMitogen-activated protein kinase 14/0.520
3u8w09JMitogen-activated protein kinase 14/0.519
4lopSB4Mitogen-activated protein kinase 14/0.519
2qd9LGFMitogen-activated protein kinase 14/0.517
3fmkFMKMitogen-activated protein kinase 14/0.509
3gfeP37Mitogen-activated protein kinase 14/0.508
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.503
4looSB4Mitogen-activated protein kinase 14/0.503
3hllI45Mitogen-activated protein kinase 14/0.500
2y6o1N1Ephrin type-A receptor 42.7.10.10.496
3gw9VNILanosterol 14-alpha-demethylase/0.494
3bv3P39Mitogen-activated protein kinase 14/0.489
3gc9B45Mitogen-activated protein kinase 112.7.11.240.487
4eh60ONMitogen-activated protein kinase 14/0.487
3hvcGG5Mitogen-activated protein kinase 14/0.486
2ghlLIBMitogen-activated protein kinase 14/0.485
1xddAAYIntegrin alpha-L/0.483
2zb1GK4Mitogen-activated protein kinase 14/0.482
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.477
4nka2K7Fibroblast growth factor receptor 1/0.476
3itzP66Mitogen-activated protein kinase 14/0.475
3roc29AMitogen-activated protein kinase 14/0.475
4bb3KKAIsopenicillin N synthase1.21.3.10.475
2zb0GK3Mitogen-activated protein kinase 14/0.474
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.473
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.473
1zyjBI5Mitogen-activated protein kinase 14/0.471
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.471
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.471
3uibSB2Putative mitogen-activated protein kinase/0.470
3w33W19Epidermal growth factor receptor2.7.10.10.469
4g3jVNTLanosterol 14-alpha-demethylase/0.469
4g7gVFVLanosterol 14-alpha-demethylase/0.469
2c3qGTXGlutathione S-transferase theta-12.5.1.180.468
2ftoCB3Thymidylate synthase/0.468
2qo9ANPEphrin type-A receptor 32.7.10.10.468
3ds6A17Mitogen-activated protein kinase 14/0.468
4bfxZVXPantothenate kinase2.7.1.330.468
4loqSB4Mitogen-activated protein kinase 14/0.468
2d29FADAcyl-CoA dehydrogenase/0.467
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.467
1hncGDNGlutathione S-transferase Mu 22.5.1.180.466
3uyt0CKCasein kinase I isoform delta2.7.11.10.465
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.465
4i22IREEpidermal growth factor receptor2.7.10.10.464
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4tvbNADHomospermidine synthase2.5.1.440.463
4yntFDAGlucose oxidase, putative/0.463
1fm4DXCMajor pollen allergen Bet v 1-L/0.461
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.461
4hnf16WCasein kinase I isoform delta2.7.11.10.461
1kvkATPMevalonate kinase2.7.1.360.460
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.460
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.459
3mpaSB2Mitogen-activated protein kinase 14/0.459
3uvqFS8Mitogen-activated protein kinase 14/0.459
1ie3NADMalate dehydrogenase/0.458
3bv2P38Mitogen-activated protein kinase 14/0.458
3sz0FADSulfide-quinone reductase/0.458
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.458
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.457
3d7zGK5Mitogen-activated protein kinase 14/0.457
3flsFLSMitogen-activated protein kinase 14/0.457
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.457
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
3cscACOCitrate synthase, mitochondrial2.3.3.10.456
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.456
4gk3L87Ephrin type-A receptor 32.7.10.10.455
5hsaFASAlcohol oxidase 11.1.3.130.455
1bk0ACVIsopenicillin N synthase1.21.3.10.454
1ma0NADAlcohol dehydrogenase class-31.1.1.10.454
3bgxMEFThymidylate synthase/0.454
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.453
1y0s331Peroxisome proliferator-activated receptor delta/0.452
2c0cNAPProstaglandin reductase 310.452
3ol5SAWCamphor 5-monooxygenase1.14.15.10.452
3w8wFADPutative FAD-dependent oxygenase EncM/0.452
4i8zG08Gag-Pol polyprotein3.4.23.160.452
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.452
2po7CHDFerrochelatase, mitochondrial4.99.1.10.451
2q7vFADThioredoxin reductase/0.451
3e5rNADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic1.2.1.120.451
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.451
1m0b0ZQGag-Pol polyprotein3.4.23.160.450
1mp0NADAlcohol dehydrogenase class-31.1.1.10.450
1nq5NADGlyceraldehyde-3-phosphate dehydrogenase/0.450
1ywrLI9Mitogen-activated protein kinase 14/0.450
1zz2B11Mitogen-activated protein kinase 14/0.450
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.450
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.450
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.450
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.450
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.450
4xq9NADHomospermidine synthase2.5.1.440.450
2cig1DGDihydrofolate reductase1.5.1.30.449
2jb4A14Isopenicillin N synthase1.21.3.10.449
3d84NDPDihydrofolate reductase1.5.1.30.449
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.449
4y8wSTRSteroid 21-hydroxylase/0.449
1qvnFRIInterleukin-2/0.448
2ien017Gag-Pol polyprotein3.4.23.160.448
2vhvNAIAlanine dehydrogenase1.4.1.10.448
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.448
3b6zCO7Enoyl reductase LovC10.448
3lqfNADGalactitol dehydrogenase/0.448
3nbwTR4Ketohexokinase/0.448
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.448
6ctsCICCitrate synthase, mitochondrial2.3.3.10.448
2gtnLIEMitogen-activated protein kinase 14/0.447
2qocANPEphrin type-A receptor 32.7.10.10.447
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.447
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.447
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4eh3NARMitogen-activated protein kinase 14/0.447
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.446
1gypNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.446
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.446
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.446
3b70NAPEnoyl reductase LovC10.446
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.446
3ksdNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.446
4g2fC07Ephrin type-A receptor 32.7.10.10.446
4kbk1QGCasein kinase I isoform delta2.7.11.10.446
4z34ON7Lysophosphatidic acid receptor 1/0.446
1nvtNAPShikimate dehydrogenase (NADP(+))/0.445
3nxxNDPDihydrofolate reductase1.5.1.30.445
3t14FADSulfide-quinone reductase/0.445
3toh079Gag-Pol polyprotein2.7.7.490.445
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
1gd1NADGlyceraldehyde-3-phosphate dehydrogenase/0.444
1ouk084Mitogen-activated protein kinase 14/0.444
2c29NAPDihydroflavonol 4-reductase/0.444
2gekGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.444
3jynNDPQuinone oxidoreductase/0.444
3kpkFADSulfide-quinone reductase/0.444
3lzs017Gag-Pol polyprotein3.4.23.160.444
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
4k9dNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.444
4kl9NDPDihydrofolate reductase1.5.1.30.444
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.444
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2itnANPEpidermal growth factor receptor2.7.10.10.443
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3hp552PMitogen-activated protein kinase 14/0.443
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.443
3p6oETGCamphor 5-monooxygenase1.14.15.10.443
3pm9FADPutative oxidoreductase/0.443
3t2zFADSulfide-quinone reductase/0.443
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
5e8wSTUTGF-beta receptor type-12.7.11.300.443
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.442
3u4cNDPNADPH-dependent reductase BacG/0.442
4ambDUDPutative glycosyl transferase/0.442
4dx9SER_ALA_VAL_THRIntegrin beta-1/0.442
4dx9SER_ALA_VAL_THRIntegrin beta-1-binding protein 1/0.442
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
5hwsNAP2-dehydropantoate 2-reductase/0.442
1hiiC20Gag-Pol polyprotein/0.441
1ipeNDPTropinone reductase 21.1.1.2360.441
1osvCHCBile acid receptor/0.441
1xe55FEPlasmepsin-23.4.23.390.441
2aa3AP0L-lactate dehydrogenase/0.441
2fde385Gag-Pol polyprotein3.4.23.160.441
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
2itvANPEpidermal growth factor receptor2.7.10.10.441
2iviACWIsopenicillin N synthase1.21.3.10.441
2q46NAPUncharacterized protein At5g02240/0.441
3bgbLJGGag-Pol polyprotein3.4.23.160.441
3bptQUE3-hydroxyisobutyryl-CoA hydrolase, mitochondrial3.1.2.40.441
3i2l2NCProtease/0.441
3i7eDJRGag-Pol polyprotein/0.441
3poz03PEpidermal growth factor receptor2.7.10.10.441
3q92XNBKetohexokinase/0.441
3uleC69Actin-related protein 3/0.441
3zh8C58Protein kinase C iota type2.7.11.130.441
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4tuvCPZCytochrome P450 1191.140.441
5eccNAPDehydrofolate reductase type I/0.441
1ae1NAPTropinone reductase 1/0.440
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.440
1xkkFMMEpidermal growth factor receptor2.7.10.10.440
2gjlFMNNitronate monooxygenase1.13.12.160.440
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.440
2zazGK1Mitogen-activated protein kinase 14/0.440
3atzFMNProstaglandin F2a synthase/0.440
3iaeD7KBenzaldehyde lyase/0.440
3qlrNDPDihydrofolate reductase1.5.1.30.440
3qm4PN0Cytochrome P450 2D6/0.440
3rhhNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase/0.440
4a87NARMajor pollen allergen Bet v 1-A/0.440
4fn4NADShort chain dehydrogenase/0.440