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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ix6ADPUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ix6ADPUncharacterized protein/1.000
4ix5ANPUncharacterized protein/0.698
3at4CCKCasein kinase II subunit alpha2.7.11.10.481
2pvlP55Casein kinase II subunit alpha2.7.11.10.477
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.475
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.475
3be9P04Casein kinase II subunit alpha2.7.11.10.474
4ez50RSCyclin-dependent kinase 62.7.11.220.472
4jr7GNPCasein kinase II subunit alpha2.7.11.10.471
2pvnP63Casein kinase II subunit alpha2.7.11.10.470
4dgnLU2Casein kinase II subunit alpha2.7.11.10.470
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.468
4j95ACPFibroblast growth factor receptor 2/0.467
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.466
3q9xEMOCasein kinase II subunit alpha2.7.11.10.466
4anmWULCasein kinase II subunit alpha2.7.11.10.466
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.464
1eh4IC1Casein kinase I homolog 12.7.11.10.462
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.461
3zh8C58Protein kinase C iota type2.7.11.130.461
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
3pe2E1BCasein kinase II subunit alpha2.7.11.10.459
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.459
2pvmP29Casein kinase II subunit alpha2.7.11.10.458
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.458
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4gub0Y4Casein kinase II subunit alpha2.7.11.10.458
5cvfATPCasein kinase II subunit alpha2.7.11.10.458
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.457
4bcmT7ZCyclin-dependent kinase 22.7.11.220.457
1pkdUCNCyclin-dependent kinase 22.7.11.220.456
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.456
2vu3LZECyclin-dependent kinase 22.7.11.220.456
1m2pHNACasein kinase II subunit alpha2.7.11.10.455
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.455
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.454
4erwSTUCyclin-dependent kinase 22.7.11.220.454
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.454
4fv6E57Mitogen-activated protein kinase 12.7.11.240.454
2vv9IM9Cyclin-dependent kinase 22.7.11.220.453
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.452
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.452
5cvhADPCasein kinase II subunit alpha2.7.11.10.451
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.450
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.450
3igoANPCalmodulin-domain protein kinase 1, putative/0.450
3zep1NXTyrosine-protein kinase JAK32.7.10.20.450
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4dgo0JWCasein kinase II subunit alpha2.7.11.10.450
4hgs15GCasein kinase I isoform gamma-32.7.11.10.450
5av2KMPDeath-associated protein kinase 12.7.11.10.450
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.449
3oroAGSSerine/threonine protein kinase/0.449
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.448
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.448
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.447
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
3u4uLNHCasein kinase II subunit alpha2.7.11.10.447
5cshATPCasein kinase II subunit alpha2.7.11.10.447
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.446
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.446
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.445
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.445
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.444
2cchATPCyclin-dependent kinase 22.7.11.220.444
3at3ATKCasein kinase II subunit alpha2.7.11.10.444
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.444
3lltANPProtein serine/threonine kinase-1/0.444
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.444
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.444
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.444
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1yvj4STTyrosine-protein kinase JAK32.7.10.20.443
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.443
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4ic7ANPMitogen-activated protein kinase 72.7.11.240.443
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2bfyH1NAurora kinase B-A2.7.11.10.442
1pjkANPCasein kinase II subunit alpha2.7.11.10.441
2j0m4STFocal adhesion kinase 12.7.10.20.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
2vtqLZACyclin-dependent kinase 22.7.11.220.441
4jia1K3Tyrosine-protein kinase JAK2/0.441
1bygSTUTyrosine-protein kinase CSK/0.440
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.440