sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ifb | PPS | Bile salt sulfotransferase | 2.8.2.14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ifb | PPS | Bile salt sulfotransferase | 2.8.2.14 | 1.000 | |
| 2zyt | PPS | Sulfotransferase 1 family member D1 | / | 0.544 | |
| 1hy3 | PPS | Estrogen sulfotransferase | 2.8.2.4 | 0.509 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.475 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.468 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.461 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.461 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3uu1 | 14B | Anthranilate phosphoribosyltransferase | / | 0.458 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.458 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.457 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.455 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.454 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3q1k | ADP | D-alanine--D-alanine ligase A | 6.3.2.4 | 0.453 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.453 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.453 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.452 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.451 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.451 | |
| 4kc1 | WS1 | Histo-blood group ABO system transferase | / | 0.450 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.450 | |
| 4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.450 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.448 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.448 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.447 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.445 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.443 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.443 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.443 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.443 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.442 | |
| 2q0g | UPU | Poly(A) polymerase, putative | / | 0.442 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.442 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.442 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.442 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.441 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.441 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.441 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1zoy | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.440 | |
| 1zoy | UQ1 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 0.440 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.440 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.440 | |
| 4q4k | FMN | Uncharacterized protein | / | 0.440 |