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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fn4NADShort chain dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fn4NADShort chain dehydrogenase/1.000
4gh5NADShort-chain dehydrogenase/reductase SDR/0.554
5jlaNADPutative short-chain dehydrogenase/reductase/0.530
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.528
3wdsNADNADH-dependent quinuclidinone reductase/0.528
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.525
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.520
2dteNAIGlucose 1-dehydrogenase related protein/0.513
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.512
1iy8NADLevodione reductase/0.510
4yaiNAIC alpha-dehydrogenase/0.510
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.510
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.509
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.508
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.507
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.505
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.505
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.504
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.503
3p19NDPPutative blue fluorescent protein/0.501
1ipeNDPTropinone reductase 21.1.1.2360.497
2wdzNADGalactitol dehydrogenase/0.497
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.497
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.496
5jydNADShort chain dehydrogenase/0.495
3d3wNAPL-xylulose reductase1.1.1.100.494
3tscNADUncharacterized protein/0.493
4j7uNAPSepiapterin reductase1.1.1.1530.493
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.492
4nbwNADShort-chain dehydrogenase/reductase SDR/0.492
4yagNAIC alpha-dehydrogenase/0.492
5lc1NADL-threonine 3-dehydrogenase/0.491
2wsbNADGalactitol dehydrogenase/0.488
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.488
3ak4NADNADH-dependent quinuclidinone reductase/0.485
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.483
1ae1NAPTropinone reductase 1/0.482
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.482
1pr9NAPL-xylulose reductase1.1.1.100.482
3sx2NADUncharacterized protein/0.481
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.480
2yy7NADL-threonine dehydrogenase/0.480
3l77NJPShort-chain alcohol dehydrogenase/0.479
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.479
4hwkNAPSepiapterin reductase1.1.1.1530.479
4j7xNAPSepiapterin reductase1.1.1.1530.479
3qrwNDPPutative ketoacyl reductase1.3.10.478
2x86NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.477
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.477
3toxNAPPutative oxidoreductase/0.477
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.477
3a1nNADNDP-sugar epimerase/0.476
3sjuNDPKeto reductase/0.476
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.476
1wntNAPL-xylulose reductase1.1.1.100.475
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.474
1xkqNDPUncharacterized protein/0.474
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.474
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.474
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.473
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.471
1xg5NAPDehydrogenase/reductase SDR family member 11/0.471
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.471
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.471
3uxyNADShort-chain dehydrogenase/reductase SDR/0.471
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.471
5idwNAPShort-chain dehydrogenase/reductase SDR/0.471
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.470
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.470
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.470
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.469
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.468
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.468
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.466
1oaaNAPSepiapterin reductase1.1.1.1530.465
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.464
1w4zNAPPutative ketoacyl reductase1.3.10.463
1x7gNAPPutative ketoacyl reductase1.3.10.463
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.463
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.463
3rj9NADAlcohol dehydrogenase1.1.1.10.462
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
4dc1NDPPutative ketoacyl reductase1.3.10.462
4idgNADPutative UDP-glucose 4-epimerase/0.462
4qecNAPElxO/0.462
3ggoNAIPrephenate dehydrogenase/0.461
1mg5NAIAlcohol dehydrogenase1.1.1.10.460
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.459
4bmvNAPShort-chain dehydrogenase/0.458
1zemNADXylitol dehydrogenase/0.455
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.455
1snyNAPLD36273p/0.454
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.454
3r3sNADPutative oxidoreductase/0.454
3s55NADPutative short-chain dehydrogenase/reductase/0.454
3a4vNADNDP-sugar epimerase/0.453
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.451
1geeNADGlucose 1-dehydrogenase1.1.1.470.451
1z7eATPBifunctional polymyxin resistance protein ArnA/0.451
1i3lNADUDP-glucose 4-epimerase/0.450
3w8eNAD3-hydroxybutyrate dehydrogenase/0.450
1rkxNADCDP-D-glucose-4,6-dehydratase/0.449
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.449
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.447
3vdqNAD3-hydroxybutyrate dehydrogenase/0.447
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.446
3tn7NJPShort-chain alcohol dehydrogenase/0.446
1sbyNADAlcohol dehydrogenase1.1.1.10.445
3w8fNAD3-hydroxybutyrate dehydrogenase/0.443
1gcoNADGlucose 1-dehydrogenase1.1.1.470.442
1n5dNDPCarbonyl reductase [NADPH] 1/0.442
1nahNADUDP-glucose 4-epimerase5.1.3.20.442
1rwbNADGlucose 1-dehydrogenase1.1.1.470.442
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.442
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.442