sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4eqr | FAD | Coenzyme A disulfide reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4eqr | FAD | Coenzyme A disulfide reductase | / | 1.000 | |
| 4em3 | FAD | Coenzyme A disulfide reductase | / | 0.668 | |
| 4eqx | FAD | Coenzyme A disulfide reductase | / | 0.575 | |
| 5bv3 | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.483 | |
| 4die | C5P | Cytidylate kinase | / | 0.473 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.472 | |
| 2emu | SAH | Diphthine synthase | / | 0.465 | |
| 3qfa | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.462 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.462 | |
| 2ejz | SAH | Diphthine synthase | / | 0.461 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.461 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.460 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.458 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.456 | |
| 3e8x | NAP | BH1520 protein | / | 0.454 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.453 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.453 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.452 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.452 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.452 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 3qw4 | U5P | Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | / | 0.451 | |
| 3rqh | B6P | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.451 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 4u7w | NDP | MxaA | / | 0.451 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.449 | |
| 2od7 | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.449 | |
| 3zuy | TCH | Transporter | / | 0.449 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.448 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.448 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.447 | |
| 2wtk | ANP | STE20-related kinase adapter protein alpha | / | 0.447 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.446 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.446 | |
| 3ts1 | TYA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.446 | |
| 3znr | NU9 | Histone deacetylase 7 | 3.5.1.98 | 0.446 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.446 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.445 | |
| 2bkz | SBC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.445 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.445 | |
| 1g28 | FMN | PHY3 | / | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.444 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.444 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.444 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.444 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.444 | |
| 1p9w | ANP | Type II secretion system protein E | / | 0.443 | |
| 1wvg | CXY | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.443 | |
| 2bsl | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.443 | |
| 2dxv | SAH | Diphthine synthase | / | 0.443 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.443 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.443 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.443 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1n5t | OAL | ActVA 6 protein | / | 0.442 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.442 | |
| 3o15 | 3NM | Thiamine-phosphate synthase | / | 0.442 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.442 | |
| 4jb1 | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.442 | |
| 4yaf | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.442 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.441 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.441 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.441 | |
| 1mf0 | GDP | Adenylosuccinate synthetase isozyme 1 | / | 0.441 | |
| 2dcn | ADP | 2-keto-3-deoxy-gluconate kinase | / | 0.441 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.441 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.440 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.440 | |
| 4xd1 | T3Q | Qdtf | / | 0.440 |