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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4buxF35Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4buxF35Tankyrase-22.4.2.301.000
4l0t1V0Tankyrase-22.4.2.300.832
4bueJQFTankyrase-22.4.2.300.797
4l341VGTankyrase-22.4.2.300.785
4bus32FTankyrase-22.4.2.300.781
4bs4A64Tankyrase-22.4.2.300.751
4buwF33Tankyrase-22.4.2.300.732
4l2g1V4Tankyrase-22.4.2.300.727
4iueAJ4Tankyrase-22.4.2.300.663
3kr8XAVTankyrase-22.4.2.300.662
4hlh20DTankyrase-22.4.2.300.658
4j22AJ7Tankyrase-22.4.2.300.656
4bufF36Tankyrase-22.4.2.300.650
4hlf15ZTankyrase-22.4.2.300.650
4l0s1UZTankyrase-22.4.2.300.648
4l31F08Tankyrase-22.4.2.300.648
4hl515WTankyrase-22.4.2.300.644
4kzl20DTankyrase-22.4.2.300.643
4l0i1UWTankyrase-22.4.2.300.643
4bu908CTankyrase-22.4.2.300.640
4l2k1V8Tankyrase-22.4.2.300.635
4l33F70Tankyrase-22.4.2.300.635
4kzuA73Tankyrase-22.4.2.300.632
4l10A63Tankyrase-22.4.2.300.631
4hlm16STankyrase-22.4.2.300.627
4bj9UHBTankyrase-22.4.2.300.626
4hlk431Tankyrase-22.4.2.300.624
4l2f1V3Tankyrase-22.4.2.300.622
4l321VFTankyrase-22.4.2.300.622
4buuF38Tankyrase-22.4.2.300.621
4hkkAGITankyrase-22.4.2.300.619
4l0v1V1Tankyrase-22.4.2.300.617
4buiW2ETankyrase-22.4.2.300.615
4bud29FTankyrase-22.4.2.300.612
4but31FTankyrase-22.4.2.300.606
5aku29FTankyrase-22.4.2.300.605
4hknLU2Tankyrase-22.4.2.300.602
4j21AJ6Tankyrase-22.4.2.300.601
3p0pNNFTankyrase-22.4.2.300.598
4avwG18Tankyrase-22.4.2.300.595
4hmhF94Tankyrase-22.4.2.300.589
4hlg20BTankyrase-22.4.2.300.579
4tkg09LTankyrase-22.4.2.300.579
4krs1SXTankyrase-12.4.2.300.574
4hkiFLNTankyrase-22.4.2.300.566
4pnrG18Tankyrase-22.4.2.300.556
4bjbP34Tankyrase-22.4.2.300.527
4l091URTankyrase-22.4.2.300.526
4buv16ITankyrase-22.4.2.300.520
4pnmNU1Tankyrase-22.4.2.300.511
4hyf1AKTankyrase-22.4.2.300.498
4j3mAJ8Tankyrase-22.4.2.300.497
3tqcADPPantothenate kinase/0.479
4j3lAJ5Tankyrase-22.4.2.300.476
4tjy3GNTankyrase-22.4.2.300.476
4avuLDRTankyrase-22.4.2.300.472
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.470
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.466
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.465
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.458
5cb3APRO-acetyl-ADP-ribose deacetylase/0.458
1xk9P34Exotoxin A2.4.2.360.457
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.453
1fmlRTLRetinol dehydratase/0.451
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.451
3k5fAYHBeta-secretase 13.4.23.460.449
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.449
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4frkDWDBeta-secretase 13.4.23.460.449
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.449
1x8lOXRRetinol dehydratase/0.448
5cb5APRO-acetyl-ADP-ribose deacetylase/0.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1opbRETRetinol-binding protein 2/0.446
2xw7NDPDihydrofolate reductase/0.446
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
3dv5BAVBeta-secretase 13.4.23.460.445
4b1hAR6Poly(ADP-ribose) glycohydrolase3.2.1.1430.445
4i9i1DYTankyrase-12.4.2.300.445
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.445
3a1nNADNDP-sugar epimerase/0.444
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.443
3cgdFADCoenzyme A disulfide reductase/0.443
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3vg10GTBeta-secretase 13.4.23.460.443
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.442
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.442
4lxk1YTBeta-secretase 13.4.23.460.442
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
3dv1AR9Beta-secretase 13.4.23.460.441
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.440
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.440