scPDB - Distribution of Binding site Similarity values of 4avw entry / Site 2

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4avw	G18	Tankyrase-2	2.4.2.30

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4avw	G18	Tankyrase-2	2.4.2.30	1.000
4l33	F70	Tankyrase-2	2.4.2.30	0.721
4hki	FLN	Tankyrase-2	2.4.2.30	0.715
4bui	W2E	Tankyrase-2	2.4.2.30	0.708
4hlg	20B	Tankyrase-2	2.4.2.30	0.703
4buu	F38	Tankyrase-2	2.4.2.30	0.690
4hlf	15Z	Tankyrase-2	2.4.2.30	0.685
4buf	F36	Tankyrase-2	2.4.2.30	0.666
4but	31F	Tankyrase-2	2.4.2.30	0.664
4l0s	1UZ	Tankyrase-2	2.4.2.30	0.664
5aku	29F	Tankyrase-2	2.4.2.30	0.659
4l32	1VF	Tankyrase-2	2.4.2.30	0.652
4l10	A63	Tankyrase-2	2.4.2.30	0.640
4l34	1VG	Tankyrase-2	2.4.2.30	0.637
4j21	AJ6	Tankyrase-2	2.4.2.30	0.634
4l2f	1V3	Tankyrase-2	2.4.2.30	0.634
4j22	AJ7	Tankyrase-2	2.4.2.30	0.630
4hlk	431	Tankyrase-2	2.4.2.30	0.629
4l2k	1V8	Tankyrase-2	2.4.2.30	0.629
4bux	F35	Tankyrase-2	2.4.2.30	0.628
4kzl	20D	Tankyrase-2	2.4.2.30	0.628
4bue	JQF	Tankyrase-2	2.4.2.30	0.625
4l31	F08	Tankyrase-2	2.4.2.30	0.618
4iue	AJ4	Tankyrase-2	2.4.2.30	0.616
4hkk	AGI	Tankyrase-2	2.4.2.30	0.615
4bu9	08C	Tankyrase-2	2.4.2.30	0.613
4hkn	LU2	Tankyrase-2	2.4.2.30	0.611
4bud	29F	Tankyrase-2	2.4.2.30	0.610
4l0i	1UW	Tankyrase-2	2.4.2.30	0.610
3u9y	09L	Tankyrase-2	2.4.2.30	0.607
4hlm	16S	Tankyrase-2	2.4.2.30	0.607
4l0t	1V0	Tankyrase-2	2.4.2.30	0.607
4hlh	20D	Tankyrase-2	2.4.2.30	0.602
4l2g	1V4	Tankyrase-2	2.4.2.30	0.602
4bj9	UHB	Tankyrase-2	2.4.2.30	0.596
4pnr	G18	Tankyrase-2	2.4.2.30	0.595
4kzu	A73	Tankyrase-2	2.4.2.30	0.591
4bus	32F	Tankyrase-2	2.4.2.30	0.587
3kr8	XAV	Tankyrase-2	2.4.2.30	0.586
4krs	1SX	Tankyrase-1	2.4.2.30	0.577
3p0p	NNF	Tankyrase-2	2.4.2.30	0.576
4hl5	15W	Tankyrase-2	2.4.2.30	0.576
4buv	16I	Tankyrase-2	2.4.2.30	0.575
4buw	F33	Tankyrase-2	2.4.2.30	0.575
4tkg	09L	Tankyrase-2	2.4.2.30	0.575
4bs4	A64	Tankyrase-2	2.4.2.30	0.565
4bjb	P34	Tankyrase-2	2.4.2.30	0.560
4pnm	NU1	Tankyrase-2	2.4.2.30	0.552
4l0v	1V1	Tankyrase-2	2.4.2.30	0.548
4hmh	F94	Tankyrase-2	2.4.2.30	0.547
4msk	2C8	Tankyrase-1	2.4.2.30	0.538
4j3l	AJ5	Tankyrase-2	2.4.2.30	0.518
4l09	1UR	Tankyrase-2	2.4.2.30	0.512
4j3m	AJ8	Tankyrase-2	2.4.2.30	0.503
4gv7	MEW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.492
4tjy	3GN	Tankyrase-2	2.4.2.30	0.485
4i9i	1DY	Tankyrase-1	2.4.2.30	0.482
1xk9	P34	Exotoxin A	2.4.2.36	0.481
2rd6	78P	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.469
1x8l	OXR	Retinol dehydratase	/	0.468
2bbq	PFG	Thymidylate synthase	/	0.468
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.466
1iol	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.464
1fml	RTL	Retinol dehydratase	/	0.462
4li8	1XQ	Tankyrase-1	2.4.2.30	0.462
3c49	KU8	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.459
1pax	DHQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.458
3zhs	TD6	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.458
4gv0	8ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.458
4avu	LDR	Tankyrase-2	2.4.2.30	0.457
4b14	4XB	Glycylpeptide N-tetradecanoyltransferase	/	0.457
2pnj	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.456
4hhy	15R	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.456
5c1m	CLR	Mu-type opioid receptor	/	0.456
4bjc	RPB	Tankyrase-2	2.4.2.30	0.455
4cf6	CBD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.455
4hhz	15S	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.453
3gn7	3GN	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.452
3rsv	3RS	Beta-secretase 1	3.4.23.46	0.452
2ejv	NAD	L-threonine 3-dehydrogenase	/	0.451
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.451
2ges	COK	Pantothenate kinase	2.7.1.33	0.450
2w4q	CBW	Prostaglandin reductase 2	1.3.1.48	0.450
3b82	NAD	Exotoxin A	2.4.2.36	0.450
4arb	C57	Acetylcholinesterase	3.1.1.7	0.450
2f38	15M	Aldo-keto reductase family 1 member C3	/	0.449
3l3m	A92	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.449
4n4v	2GY	Tankyrase-1	2.4.2.30	0.449
1opb	RET	Retinol-binding protein 2	/	0.448
3bgi	SAH	Thiopurine S-methyltransferase	2.1.1.67	0.448
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.448
2fto	CB3	Thymidylate synthase	/	0.446
3zht	TD9	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.446
3ox4	NAD	Alcohol dehydrogenase 2	1.1.1.1	0.445
4li6	1XO	Tankyrase-1	2.4.2.30	0.445
3iaa	TYD	CalG2	/	0.444
1xf0	ASD	Aldo-keto reductase family 1 member C3	/	0.443
3uzw	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.443
4gv2	5ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.442
3g5s	FAD	Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO	/	0.441
1i7p	FAD	NADH-cytochrome b5 reductase 3	1.6.2.2	0.440
2g8y	NAD	Hydroxycarboxylate dehydrogenase B	/	0.440
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.440
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.440