sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4aql | TXC | Guanine deaminase | 3.5.4.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4aql | TXC | Guanine deaminase | 3.5.4.3 | 1.000 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.478 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.478 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.477 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.475 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.475 | |
| 4xwt | U5P | Ribonuclease J | / | 0.472 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.467 | |
| 2ejz | SAH | Diphthine synthase | / | 0.466 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.462 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.462 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.461 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.460 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.459 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.458 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 3htj | ET | EbrA repressor | / | 0.455 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.454 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.453 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 2iog | IOG | Estrogen receptor | / | 0.451 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.451 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.451 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.450 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.449 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4ydq | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.449 | |
| 1efa | NPF | Lactose operon repressor | / | 0.448 | |
| 3v4t | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.448 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.447 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.446 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.446 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.446 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 4c2z | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.446 | |
| 4q15 | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.446 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.445 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.445 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.444 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.444 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.444 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.444 | |
| 4o95 | 245 | Cytokinin dehydrogenase 4 | / | 0.443 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.443 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.442 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.442 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.442 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.442 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.442 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.441 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 3c6t | M14 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.441 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.441 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.441 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.440 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.440 |