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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3uqdATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3uqdATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.111.000
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.568
3umoATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.561
3uqdADPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.489
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.483
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.472
1kifFADD-amino-acid oxidase1.4.3.30.471
2ft9CHDFatty acid-binding protein 2, liver/0.466
3lpkZ76Beta-secretase 13.4.23.460.465
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
3qbhQBHBeta-secretase 13.4.23.460.464
4n9iPCGCatabolite expression activator/0.462
1likADNAdenosine kinase2.7.1.200.460
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1gqtACPRibokinase/0.458
1k6tXN1Gag-Pol polyprotein3.4.23.160.458
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.458
5c41ACPRibokinase/0.458
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.457
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.455
3nbvANPKetohexokinase/0.454
4bfxZVXPantothenate kinase2.7.1.330.454
2qo9ANPEphrin type-A receptor 32.7.10.10.453
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.452
3wfjNAD2-dehydropantoate 2-reductase/0.452
5br7FADUDP-galactopyranose mutase/0.452
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.451
2obyNAPQuinone oxidoreductase PIG310.450
2y0mACOHistone acetyltransferase KAT8/0.450
3a1nNADNDP-sugar epimerase/0.450
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.449
2geuCOKPantothenate kinase2.7.1.330.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.448
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.448
3cgoJNOMitogen-activated protein kinase 102.7.11.240.448
3mjhGTPRas-related protein Rab-5A/0.448
4yxm2BADNA integrity scanning protein DisA/0.448
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.447
3c1y2BADNA integrity scanning protein DisA/0.447
3cluFADElectron transfer flavoprotein subunit alpha/0.447
3p62FMNPentaerythritol tetranitrate reductase/0.447
3vvpBNUUncharacterized protein/0.447
1pr9NAPL-xylulose reductase1.1.1.100.446
4bftZVTPantothenate kinase2.7.1.330.446
5a3bAPRSIR2 family protein/0.446
2vnaNAPProstaglandin reductase 21.3.1.480.445
3clsFADElectron transfer flavoprotein subunit alpha/0.445
4grb0XGCasein kinase II subunit alpha2.7.11.10.445
1ng4FADGlycine oxidase1.4.3.190.444
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.444
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.444
5hwsNAP2-dehydropantoate 2-reductase/0.444
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.443
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1o97FADElectron transfer flavoprotein subunit alpha/0.443
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.443
1glfADPGlycerol kinase/0.442
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2xpuTDCTetracycline repressor protein class D/0.442
3b70NAPEnoyl reductase LovC10.442
3clrFADElectron transfer flavoprotein subunit alpha/0.442
3zcw4A2Kinesin-like protein KIF11/0.442
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.441
3frqERYErythromycin resistance repressor protein/0.441
4nxvGDPMitochondrial dynamics protein MID51/0.441
1w4zNAPPutative ketoacyl reductase1.3.10.440
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
3b20NADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.440
3qrwNDPPutative ketoacyl reductase1.3.10.440
3sdi3SDProteasome subunit beta type-53.4.25.10.440
3sdi3SDProteasome subunit beta type-63.4.25.10.440
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.440