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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3sx2NADUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3sx2NADUncharacterized protein/1.000
3tscNADUncharacterized protein/0.578
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.576
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.572
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.559
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.553
1iy8NADLevodione reductase/0.552
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.550
3s55NADPutative short-chain dehydrogenase/reductase/0.549
4yagNAIC alpha-dehydrogenase/0.548
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.547
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.545
4yaiNAIC alpha-dehydrogenase/0.543
5jlaNADPutative short-chain dehydrogenase/reductase/0.543
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.539
2wdzNADGalactitol dehydrogenase/0.539
4j7uNAPSepiapterin reductase1.1.1.1530.539
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.533
2wsbNADGalactitol dehydrogenase/0.533
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.533
4gh5NADShort-chain dehydrogenase/reductase SDR/0.532
3wdsNADNADH-dependent quinuclidinone reductase/0.531
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.531
1ae1NAPTropinone reductase 1/0.530
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.529
2dteNAIGlucose 1-dehydrogenase related protein/0.529
4fn4NADShort chain dehydrogenase/0.527
4nbwNADShort-chain dehydrogenase/reductase SDR/0.527
1ipeNDPTropinone reductase 21.1.1.2360.524
4j7xNAPSepiapterin reductase1.1.1.1530.523
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.522
3ak4NADNADH-dependent quinuclidinone reductase/0.520
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.519
4qecNAPElxO/0.518
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.517
1snyNAPLD36273p/0.517
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.516
1x7gNAPPutative ketoacyl reductase1.3.10.516
1xg5NAPDehydrogenase/reductase SDR family member 11/0.516
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.516
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.514
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.512
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.511
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.511
3lqfNADGalactitol dehydrogenase/0.511
5ig2NADShort-chain dehydrogenase/reductase SDR/0.510
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.509
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.508
4hwkNAPSepiapterin reductase1.1.1.1530.508
3d3wNAPL-xylulose reductase1.1.1.100.506
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.506
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.505
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.505
3p19NDPPutative blue fluorescent protein/0.504
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.501
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.501
1mg5NAIAlcohol dehydrogenase1.1.1.10.497
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.497
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.497
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.497
1wntNAPL-xylulose reductase1.1.1.100.496
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.494
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.493
3uxyNADShort-chain dehydrogenase/reductase SDR/0.493
5jydNADShort chain dehydrogenase/0.493
1pr9NAPL-xylulose reductase1.1.1.100.492
1zemNADXylitol dehydrogenase/0.491
5idwNAPShort-chain dehydrogenase/reductase SDR/0.491
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.489
3rj5NADAlcohol dehydrogenase1.1.1.10.488
4bmvNAPShort-chain dehydrogenase/0.487
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.487
4dc1NDPPutative ketoacyl reductase1.3.10.486
5jy1NADPutative short-chain dehydrogenase/reductase/0.486
2jahNDPClavaldehyde dehydrogenase/0.485
1oaaNAPSepiapterin reductase1.1.1.1530.483
1x7hNDPPutative ketoacyl reductase1.3.10.483
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.483
1n5dNDPCarbonyl reductase [NADPH] 1/0.481
1w4zNAPPutative ketoacyl reductase1.3.10.481
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.479
3l77NJPShort-chain alcohol dehydrogenase/0.478
3w8eNAD3-hydroxybutyrate dehydrogenase/0.478
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.476
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
2p5uNADUDP-glucose 4-epimerase/0.473
3sjuNDPKeto reductase/0.473
3toxNAPPutative oxidoreductase/0.473
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.472
3qrwNDPPutative ketoacyl reductase1.3.10.472
1b15NAEAlcohol dehydrogenase1.1.1.10.471
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.471
2yutNAPPutative short-chain oxidoreductase/0.471
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.471
1geeNADGlucose 1-dehydrogenase1.1.1.470.470
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.469
1rwbNADGlucose 1-dehydrogenase1.1.1.470.468
3a1nNADNDP-sugar epimerase/0.468
4idgNADPutative UDP-glucose 4-epimerase/0.468
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.467
3tn7NJPShort-chain alcohol dehydrogenase/0.467
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.466
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.466
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.466
1sbyNADAlcohol dehydrogenase1.1.1.10.465
2bd0NAPSepiapterin reductase/0.465
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.465
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.463
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.462
3vdqNAD3-hydroxybutyrate dehydrogenase/0.462
1g6kNADGlucose 1-dehydrogenase1.1.1.470.461
3w8fNAD3-hydroxybutyrate dehydrogenase/0.461
4b79NADProbable short-chain dehydrogenase/0.461
1gcoNADGlucose 1-dehydrogenase1.1.1.470.459
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.459
5lc1NADL-threonine 3-dehydrogenase/0.459
1b16NAQAlcohol dehydrogenase1.1.1.10.458
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.458
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.457
3gy0NAPNAD(P)-dependent oxidoreductase/0.456
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1i3lNADUDP-glucose 4-epimerase/0.453
2yy7NADL-threonine dehydrogenase/0.453
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.452
1xkqNDPUncharacterized protein/0.452
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.452
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.452
1b14NADAlcohol dehydrogenase1.1.1.10.451
3a4vNADNDP-sugar epimerase/0.449
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.449
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.448
1f8wFADNADH peroxidase1.11.1.10.448
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.448
3syiFADSulfide-quinone reductase/0.448
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.447
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
5dcyNAPIridoid synthase1.3.1.990.446
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.445
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.444
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
2givACOHistone acetyltransferase KAT8/0.440
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.440
3ggoNAIPrephenate dehydrogenase/0.440
4esoNAPPutative oxidoreductase/0.440