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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rj5NADAlcohol dehydrogenase1.1.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rj5NADAlcohol dehydrogenase1.1.1.11.000
1b15NAEAlcohol dehydrogenase1.1.1.10.663
1b14NADAlcohol dehydrogenase1.1.1.10.631
1b16NAQAlcohol dehydrogenase1.1.1.10.631
3rj9NADAlcohol dehydrogenase1.1.1.10.626
1mg5NAIAlcohol dehydrogenase1.1.1.10.584
1sbyNADAlcohol dehydrogenase1.1.1.10.581
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.534
5lc1NADL-threonine 3-dehydrogenase/0.531
5jlaNADPutative short-chain dehydrogenase/reductase/0.527
3uxyNADShort-chain dehydrogenase/reductase SDR/0.525
3a4vNADNDP-sugar epimerase/0.524
4gh5NADShort-chain dehydrogenase/reductase SDR/0.523
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.522
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.519
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.519
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.518
3wdsNADNADH-dependent quinuclidinone reductase/0.512
1iy8NADLevodione reductase/0.511
3ak4NADNADH-dependent quinuclidinone reductase/0.508
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.508
1pr9NAPL-xylulose reductase1.1.1.100.506
2wsbNADGalactitol dehydrogenase/0.504
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.501
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.500
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.500
1zemNADXylitol dehydrogenase/0.497
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.496
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.496
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.496
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.495
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.493
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.492
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.491
1xg5NAPDehydrogenase/reductase SDR family member 11/0.490
2dteNAIGlucose 1-dehydrogenase related protein/0.490
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.485
3gy0NAPNAD(P)-dependent oxidoreductase/0.484
3a1nNADNDP-sugar epimerase/0.483
3toxNAPPutative oxidoreductase/0.482
1wntNAPL-xylulose reductase1.1.1.100.481
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.480
2yutNAPPutative short-chain oxidoreductase/0.480
2wdzNADGalactitol dehydrogenase/0.479
3qrwNDPPutative ketoacyl reductase1.3.10.479
4dc1NDPPutative ketoacyl reductase1.3.10.479
4qecNAPElxO/0.479
1w4zNAPPutative ketoacyl reductase1.3.10.478
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.478
2yy7NADL-threonine dehydrogenase/0.477
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.477
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.476
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.476
1xkqNDPUncharacterized protein/0.475
3w8eNAD3-hydroxybutyrate dehydrogenase/0.475
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.475
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.473
3w8fNAD3-hydroxybutyrate dehydrogenase/0.472
4bmvNAPShort-chain dehydrogenase/0.472
3d3wNAPL-xylulose reductase1.1.1.100.471
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.471
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.470
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.470
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.469
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.469
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.469
1ae1NAPTropinone reductase 1/0.468
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.468
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.467
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.466
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.466
1snyNAPLD36273p/0.465
3sjuNDPKeto reductase/0.464
3sx2NADUncharacterized protein/0.464
1x7hNDPPutative ketoacyl reductase1.3.10.463
4j7uNAPSepiapterin reductase1.1.1.1530.463
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.462
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.462
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.461
1ipeNDPTropinone reductase 21.1.1.2360.460
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.460
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.459
2p5uNADUDP-glucose 4-epimerase/0.459
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.459
3ai2NDPNADPH-sorbose reductase/0.457
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.457
3s55NADPutative short-chain dehydrogenase/reductase/0.457
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.456
4impNDPPolyketide synthase extender modules 3-4/0.456
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.456
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.455
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.454
3ggoNAIPrephenate dehydrogenase/0.454
1g1aNADdTDP-glucose 4,6-dehydratase/0.453
3w8dNAD3-hydroxybutyrate dehydrogenase/0.453
3ajrNADNDP-sugar epimerase/0.451
3uceNDPDehydrogenase/0.451
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.450
5idwNAPShort-chain dehydrogenase/reductase SDR/0.450
4j7xNAPSepiapterin reductase1.1.1.1530.449
1z7eATPBifunctional polymyxin resistance protein ArnA/0.448
3lqfNADGalactitol dehydrogenase/0.448
1n5dNDPCarbonyl reductase [NADPH] 1/0.447
4fn4NADShort chain dehydrogenase/0.447
4qedNAPElxO/0.447
4yaiNAIC alpha-dehydrogenase/0.447
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.447
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.444
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.441
4hwkNAPSepiapterin reductase1.1.1.1530.441
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.440