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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ocpCMPcGMP-dependent protein kinase 12.7.11.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ocpCMPcGMP-dependent protein kinase 12.7.11.121.000
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.506
1y0s331Peroxisome proliferator-activated receptor delta/0.480
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.479
2znq401Peroxisome proliferator-activated receptor delta/0.473
1xddAAYIntegrin alpha-L/0.472
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.469
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.464
3kxw1ZZSaframycin Mx1 synthetase B/0.464
2gjlFMNNitronate monooxygenase1.13.12.160.463
2uxpCLMHTH-type transcriptional regulator TtgR/0.463
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.459
5dp2NAPCurF/0.459
2znnS44Peroxisome proliferator-activated receptor alpha/0.458
3sz0FADSulfide-quinone reductase/0.458
4ix6ADPUncharacterized protein/0.458
4h3ySAHtRNA (guanine-N(1)-)-methyltransferase/0.456
1me6IVSPlasmepsin-23.4.23.390.455
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.455
1msmJE2Gag-Pol polyprotein3.4.23.160.454
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.454
2q59240Peroxisome proliferator-activated receptor gamma/0.454
4c58824Cyclin-G-associated kinase2.7.11.10.454
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.453
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.453
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.453
4ix5ANPUncharacterized protein/0.453
4q72FADBifunctional protein PutA/0.453
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.453
4fv6E57Mitogen-activated protein kinase 12.7.11.240.452
4q73FADBifunctional protein PutA/0.452
3ik6HCZGlutamate receptor 2/0.451
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.451
1eioGCHGastrotropin/0.450
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.450
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.449
3syiFADSulfide-quinone reductase/0.449
4a6bQG8Gag-Pol polyprotein3.4.23.160.449
3ad9NADSubunit alpha of sarocosine oxidase/0.448
3c50ADPRhodopsin kinase/0.448
1w6hTITPlasmepsin-23.4.23.390.447
2om9AJAPeroxisome proliferator-activated receptor gamma/0.447
3ig6438Urokinase-type plasminogen activator3.4.21.730.447
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.447
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.447
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.446
3frqERYErythromycin resistance repressor protein/0.446
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.446
3i60E86Mitogen-activated protein kinase 12.7.11.240.446
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.446
4q71FADBifunctional protein PutA/0.446
1bygSTUTyrosine-protein kinase CSK/0.445
1kkq471Peroxisome proliferator-activated receptor alpha/0.445
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.445
4nmdFDABifunctional protein PutA/0.445
1k7l544Peroxisome proliferator-activated receptor alpha/0.444
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.444
3bc3OPTCathepsin L13.4.22.150.444
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.444
3h8bNSYCathepsin L13.4.22.150.444
3kpkFADSulfide-quinone reductase/0.444
3s4qNK0Mitogen-activated protein kinase 14/0.444
3zuxTCHTransporter/0.444
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.444
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.444
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.443
1psa0ZLPepsin A3.4.23.10.443
2uxhQUEHTH-type transcriptional regulator TtgR/0.443
4bfxZVXPantothenate kinase2.7.1.330.443
4jq8KJ8Epidermal growth factor receptor2.7.10.10.443
4loqSB4Mitogen-activated protein kinase 14/0.443
4m10ICDProstaglandin G/H synthase 21.14.99.10.443
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
1bdlIM1Gag-Pol polyprotein3.4.23.160.442
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.442
3t2zFADSulfide-quinone reductase/0.442
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1p9wANPType II secretion system protein E/0.441
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.441
2npaMMBPeroxisome proliferator-activated receptor alpha/0.441
3t2yFADSulfide-quinone reductase/0.441
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.441
1k6tXN1Gag-Pol polyprotein3.4.23.160.440
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.440
3ajrNADNDP-sugar epimerase/0.440
3h0aD30Peroxisome proliferator-activated receptor gamma/0.440
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.440
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.440
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440