sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3lsi | FAD | Pyranose 2-oxidase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3lsi | FAD | Pyranose 2-oxidase | / | 1.000 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.672 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.638 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.618 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.603 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.596 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.572 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.539 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.502 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.494 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.475 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.472 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.472 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.471 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.471 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.470 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.469 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.467 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.465 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.463 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.463 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.463 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.462 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.462 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.460 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.460 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.459 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.458 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.456 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.454 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.453 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.453 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.452 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.452 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.452 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.451 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.451 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.451 | |
| 5j60 | FAD | Thioredoxin reductase | / | 0.451 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.450 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.450 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.449 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.449 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.448 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.447 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.447 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.446 | |
| 3d64 | NAD | Adenosylhomocysteinase | / | 0.446 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.446 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 1nqo | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 3wag | TYD | Glycosyltransferase | / | 0.445 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.445 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.445 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.444 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.444 | |
| 3vqr | FAD | Putative oxidoreductase | / | 0.443 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.443 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.442 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.442 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.442 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.442 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.441 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.440 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.440 |