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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gphOIDCytochrome P450 2E11.14.13

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gphOIDCytochrome P450 2E11.14.131.000
4ejh0QACytochrome P450 2A131.14.14.10.532
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.504
4i8vBHFCytochrome P450 1A11.14.14.10.499
3a1l2CCCytochrome P450/0.498
3tdaPN0Cytochrome P450 2D6/0.497
3qm4PN0Cytochrome P450 2D6/0.493
3t3q9PLCytochrome P450 2A61.14.130.493
1suoCPZCytochrome P450 2B41.14.14.10.483
3tk3CPZCytochrome P450 2B41.14.14.10.480
4ejgNCTCytochrome P450 2A131.14.14.10.475
4j6cSTRCytochrome P450 monooxygenase/0.475
3q0vLL4HTH-type transcriptional regulator EthR/0.474
4ktkKTKCytochrome P450/0.474
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.474
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.473
4r21STRCytochrome P450 family 17 polypeptide 2/0.472
3ibdCPZCytochrome P450 2B61.14.130.468
3pm0BHFCytochrome P450 1B1/0.467
4ktl1CQCytochrome P450/0.467
3nxuRITCytochrome P450 3A4/0.465
3tguWF3Cytochrome b/0.465
2hcdBIVVitamin D3 receptor A/0.464
4iarERM5-hydroxytryptamine receptor 1B/0.462
3t3r9PLCytochrome P450 2A61.14.130.461
3g1mRF3HTH-type transcriptional regulator EthR/0.460
4ia3BIVVitamin D3 receptor A/0.460
4r20AERCytochrome P450 family 17 polypeptide 2/0.460
1dtpAPUDiphtheria toxin/0.459
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.459
3l70JZVCytochrome b/0.459
3p99LNPLanosterol 14-alpha-demethylase/0.459
4ia2BIVVitamin D3 receptor A/0.459
4j6bPLOCytochrome P450 monooxygenase/0.459
4g1z0VPVitamin D3 receptor A/0.458
1cd2FOLDihydrofolate reductase1.5.1.30.457
5uviZMAAdenosine receptor A2a/0.457
2z3uCRRCytochrome P450/0.456
2z97CAMCamphor 5-monooxygenase1.14.15.10.456
3p3zP3ZPutative cytochrome P450/0.456
4j6dTESCytochrome P450 monooxygenase/0.456
2a1nCAMCamphor 5-monooxygenase1.14.15.10.455
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.455
3pwhZMAAdenosine receptor A2a/0.455
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.454
3g5hYTTMycocyclosin synthase1.14.21.90.454
4y8wSTRSteroid 21-hydroxylase/0.454
1ek2CDUBifunctional epoxide hydrolase 2/0.453
4l49CAMCamphor 5-monooxygenase1.14.15.10.453
1powFADPyruvate oxidase1.2.3.30.452
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.452
3u8hBHPPhospholipase A2, membrane associated/0.452
3qly55VUncharacterized protein/0.451
3w0yDS4Vitamin D3 receptor/0.451
4g48PZBMycocyclosin synthase1.14.21.90.451
4nc3ERM5-hydroxytryptamine receptor 2B/0.451
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.451
1s3uTQDDihydrofolate reductase1.5.1.30.450
2b5j3ACGag-Pol polyprotein2.7.7.490.450
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
4c9pCAMCytochrome P450/0.450
3dlgGWEGag-Pol polyprotein2.7.7.490.449
3jx3JI5Nitric oxide synthase, brain1.14.13.390.449
4g2gTDHMycocyclosin synthase1.14.21.90.449
3w0aDS5Vitamin D3 receptor/0.448
2m56CAMCamphor 5-monooxygenase1.14.15.10.447
1phgMYTCamphor 5-monooxygenase1.14.15.10.446
3vt65YIVitamin D3 receptor/0.446
4ia1BIVVitamin D3 receptor A/0.446
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.446
1poxFADPyruvate oxidase1.2.3.30.445
3is9AC7Gag-Pol polyprotein2.7.7.490.445
3jwtJI5Nitric oxide synthase, brain1.14.13.390.445
4ips1G4Mycocyclosin synthase1.14.21.90.445
4uymVOR14-alpha sterol demethylase Cyp51B/0.445
1fmlRTLRetinol dehydratase/0.444
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4bhw01KHistone acetyltransferase p300/0.443
4ia7BIVVitamin D3 receptor A/0.443
4ib4ERM5-hydroxytryptamine receptor 2B/0.443
4iq71G9Mycocyclosin synthase1.14.21.90.443
4ict1EDMycocyclosin synthase1.14.21.90.442
4o701QKBromodomain-containing protein 4/0.442
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
1dz6CAMCamphor 5-monooxygenase1.14.15.10.441
1hb1OCVIsopenicillin N synthase1.21.3.10.441
3nlqJRRNitric oxide synthase, brain1.14.13.390.441
5k2bZMAAdenosine receptor A2a/0.441
1ie8KH1Vitamin D3 receptor/0.440
1o6rR19Squalene--hopene cyclase4.2.1.1290.440
2gpvOHTEstrogen-related receptor gamma/0.440
2iyaZIOOleandomycin glycosyltransferase/0.440
3fwjCAMCamphor 5-monooxygenase1.14.15.10.440
3kpzZNEVitamin D3 receptor/0.440