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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3f69XDRSerine/threonine-protein kinase PknB2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3f69XDRSerine/threonine-protein kinase PknB2.7.11.11.000
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.540
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.508
3l8p0CEAngiopoietin-1 receptor2.7.10.10.507
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.500
3ttjJBIMitogen-activated protein kinase 102.7.11.240.497
3gubGUBDeath-associated protein kinase 12.7.11.10.493
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.492
2vu3LZECyclin-dependent kinase 22.7.11.220.491
1pmn984Mitogen-activated protein kinase 102.7.11.240.488
3i60E86Mitogen-activated protein kinase 12.7.11.240.488
4hvi19STyrosine-protein kinase JAK32.7.10.20.487
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.487
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.485
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.484
3be9P04Casein kinase II subunit alpha2.7.11.10.483
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.483
5e8ySTUTGF-beta receptor type-22.7.11.300.483
3ormAGSSerine/threonine protein kinase/0.481
3rak03ZCyclin-dependent kinase 22.7.11.220.480
2w05FRTCyclin-dependent kinase 22.7.11.220.478
2h96893Mitogen-activated protein kinase 82.7.11.240.477
2pvhP19Casein kinase II subunit alpha2.7.11.10.477
4jqeANPCasein kinase II subunit alpha2.7.11.10.477
2pvnP63Casein kinase II subunit alpha2.7.11.10.476
3gxlQIGTGF-beta receptor type-12.7.11.300.476
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.475
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.474
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.474
5e8wSTUTGF-beta receptor type-12.7.11.300.474
2ckeIQUDeath-associated protein kinase 2/0.472
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.472
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.472
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.471
3ttiKBIMitogen-activated protein kinase 102.7.11.240.471
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.471
3cgfJNFMitogen-activated protein kinase 102.7.11.240.470
3zewSTUEphrin type-B receptor 42.7.10.10.470
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.470
2p33J07Mitogen-activated protein kinase 102.7.11.240.469
2vttLZDCyclin-dependent kinase 22.7.11.220.469
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.469
4jia1K3Tyrosine-protein kinase JAK2/0.468
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.467
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.467
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.467
3uli1N3Cyclin-dependent kinase 22.7.11.220.467
4hvh19RTyrosine-protein kinase JAK32.7.10.20.467
4qnyANPMitogen activated protein kinase, putative/0.467
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.465
4bgg844Activin receptor type-12.7.11.300.465
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.465
4anmWULCasein kinase II subunit alpha2.7.11.10.464
4dgnLU2Casein kinase II subunit alpha2.7.11.10.464
5av2KMPDeath-associated protein kinase 12.7.11.10.464
1m2pHNACasein kinase II subunit alpha2.7.11.10.462
2excJNKMitogen-activated protein kinase 102.7.11.240.462
3eljGS7Mitogen-activated protein kinase 82.7.11.240.462
4e4m0NHTyrosine-protein kinase JAK2/0.462
4erwSTUCyclin-dependent kinase 22.7.11.220.462
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.462
4nka2K7Fibroblast growth factor receptor 1/0.462
5dnrATPAurora kinase A2.7.11.10.462
1xjdSTUProtein kinase C theta type2.7.11.130.461
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.461
3s1h56ZCyclin-dependent kinase 22.7.11.220.460
3t8oATPRhodopsin kinase/0.459
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.459
4ez50RSCyclin-dependent kinase 62.7.11.220.459
1bygSTUTyrosine-protein kinase CSK/0.458
3t3c017Gag-Pol polyprotein3.4.23.160.458
4wsqKSAAP2-associated protein kinase 12.7.11.10.458
1fvv107Cyclin-dependent kinase 22.7.11.220.456
1pkdUCNCyclin-dependent kinase 22.7.11.220.456
2j0m4STFocal adhesion kinase 12.7.10.20.456
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.456
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.456
2xa4AZ5Tyrosine-protein kinase JAK2/0.455
3le62BZCyclin-dependent kinase 22.7.11.220.455
4aqc88ATyrosine-protein kinase JAK2/0.455
4fkv61KCyclin-dependent kinase 22.7.11.220.455
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.454
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.454
3gc9B45Mitogen-activated protein kinase 112.7.11.240.454
3oriAGSSerine/threonine protein kinase/0.454
2x1nX1NCyclin-dependent kinase 22.7.11.220.453
2zdt46CMitogen-activated protein kinase 102.7.11.240.453
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.453
3oroAGSSerine/threonine protein kinase/0.453
3r9dX6BCyclin-dependent kinase 22.7.11.220.453
3rk708ZCyclin-dependent kinase 22.7.11.220.453
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.453
5dosATPAurora kinase A2.7.11.10.453
3kvxFMYMitogen-activated protein kinase 102.7.11.240.452
3lfqA28Cyclin-dependent kinase 22.7.11.220.452
2fvdLIACyclin-dependent kinase 22.7.11.220.451
3lltANPProtein serine/threonine kinase-1/0.451
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.451
1jklANPDeath-associated protein kinase 12.7.11.10.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.450
2iw84SPCyclin-dependent kinase 22.7.11.220.450
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.450
4hge15VTyrosine-protein kinase JAK2/0.450
4jr7GNPCasein kinase II subunit alpha2.7.11.10.450
4utdACPAurora kinase A2.7.11.10.450
1di8DTQCyclin-dependent kinase 22.7.11.220.449
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.449
3at4CCKCasein kinase II subunit alpha2.7.11.10.449
3r9oZ71Cyclin-dependent kinase 22.7.11.220.449
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.449
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4jbpYPHAurora kinase A2.7.11.10.449
1aq1STUCyclin-dependent kinase 22.7.11.220.448
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.448
2dwbANPAurora kinase A2.7.11.10.448
2xikJ60Serine/threonine-protein kinase 252.7.11.10.448
3rkb12ZCyclin-dependent kinase 22.7.11.220.448
3w2sW2REpidermal growth factor receptor2.7.10.10.448
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.448
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.447
1u4dDBQActivated CDC42 kinase 1/0.447
1yvj4STTyrosine-protein kinase JAK32.7.10.20.447
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.447
4o0wADNAurora kinase A2.7.11.10.447
5av3KMPDeath-associated protein kinase 12.7.11.10.447
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.446
4c4g7RODual specificity protein kinase TTK2.7.12.10.446
4ic7ANPMitogen-activated protein kinase 72.7.11.240.446
1hvsA77Gag-Pol polyprotein/0.445
1pxmCK5Cyclin-dependent kinase 22.7.11.220.445
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4i22IREEpidermal growth factor receptor2.7.10.10.445
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.444
4grb0XGCasein kinase II subunit alpha2.7.11.10.444
5dt3ATPAurora kinase A2.7.11.10.444
2eufLQQCyclin-dependent kinase 62.7.11.220.443
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.443
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.443
4fko20KCyclin-dependent kinase 22.7.11.220.443
4j95ACPFibroblast growth factor receptor 2/0.443
1gih1PUCyclin-dependent kinase 22.7.11.220.442
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3w18N13Aurora kinase A2.7.11.10.442
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.442
4bcmT7ZCyclin-dependent kinase 22.7.11.220.442
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.442
4dgmAGICasein kinase II subunit alpha2.7.11.10.442
4gmy0X5Tyrosine-protein kinase JAK2/0.442
2c6eHPMAurora kinase A2.7.11.10.441
2vv9IM9Cyclin-dependent kinase 22.7.11.220.441
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.441
3sheI85MAP kinase-activated protein kinase 32.7.11.10.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.441
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
5drdATPAurora kinase A2.7.11.10.441
5e8xSTUTGF-beta receptor type-12.7.11.300.441
1oguST8Cyclin-dependent kinase 22.7.11.220.440
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2vtqLZACyclin-dependent kinase 22.7.11.220.440
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.440
2xneASHAurora kinase A2.7.11.10.440
3gu6ADPDeath-associated protein kinase 12.7.11.10.440
3k5uPFQAurora kinase A2.7.11.10.440
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4fv6E57Mitogen-activated protein kinase 12.7.11.240.440
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.440
4lfiGNPCasein kinase II subunit alpha2.7.11.10.440