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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2w6nOA2Biotin carboxylase6.3.4.14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2w6nOA2Biotin carboxylase6.3.4.141.000
2v5aLZLBiotin carboxylase6.3.4.140.636
2w71L23Biotin carboxylase6.3.4.140.586
2v58LZJBiotin carboxylase6.3.4.140.580
2v59LZKBiotin carboxylase6.3.4.140.546
2w6pOA4Biotin carboxylase6.3.4.140.517
2w6zL21Biotin carboxylase6.3.4.140.510
2vr1ATFBiotin carboxylase6.3.4.140.504
2w6qOA5Biotin carboxylase6.3.4.140.489
4l8u9AZSerum albumin/0.476
3f03FMNPentaerythritol tetranitrate reductase/0.463
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
5e8wSTUTGF-beta receptor type-12.7.11.300.462
4mv8ACPBiotin carboxylase6.3.4.140.460
1u3cFADCryptochrome-1/0.459
2jn3JN3Fatty acid-binding protein, liver/0.459
1cjkFOKAdenylate cyclase type 2/0.458
1cjkFOKAdenylate cyclase type 5/0.458
3own3OWRenin3.4.23.150.458
1gqtACPRibokinase/0.456
3jzfJZKBiotin carboxylase6.3.4.140.456
3vtcTK3Vitamin D3 receptor/0.453
2ghlLIBMitogen-activated protein kinase 14/0.451
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.451
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.450
3vt3VDXVitamin D3 receptor/0.450
4gk2L66Ephrin type-A receptor 32.7.10.10.450
1i6xCMPcAMP-activated global transcriptional regulator CRP/0.449
2itqITQEpidermal growth factor receptor2.7.10.10.449
3wbbNAPMeso-diaminopimelate D-dehydrogenase/0.449
2vn0TDZCytochrome P450 2C8/0.448
2w6oOA3Biotin carboxylase6.3.4.140.448
4gk3L87Ephrin type-A receptor 32.7.10.10.448
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3vt45YIVitamin D3 receptor/0.447
1culFOKAdenylate cyclase type 2/0.446
1culFOKAdenylate cyclase type 5/0.446
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.446
3rypCMPcAMP-activated global transcriptional regulator CRP/0.446
1xddAAYIntegrin alpha-L/0.445
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.445
2jb4A14Isopenicillin N synthase1.21.3.10.444
3drcMTXDihydrofolate reductase1.5.1.30.444
3iaaTYDCalG2/0.444
4mv4ACPBiotin carboxylase6.3.4.140.444
2zbaZBATrichothecene 3-O-acetyltransferase/0.443
4v12POGMaoC like domain protein/0.443
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1np7FADCryptochrome DASH/0.442
2hcdBIVVitamin D3 receptor A/0.442
2tpsTPSThiamine-phosphate synthase/0.442
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.442
3jziJZLBiotin carboxylase6.3.4.140.442
3s1dZIRCytokinin dehydrogenase 11.5.99.120.442
3vrwYS5Vitamin D3 receptor/0.442
1bsvNDPGDP-L-fucose synthase/0.441
1vsvNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
3tdvGDPGentamicin resistance protein/0.441
4r20AERCytochrome P450 family 17 polypeptide 2/0.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1o76CAMCamphor 5-monooxygenase1.14.15.10.440
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2c3qGTXGlutathione S-transferase theta-12.5.1.180.440
2vwx7X4Ephrin type-B receptor 42.7.10.10.440
2zjwREFCasein kinase II subunit alpha2.7.11.10.440
4fod0UVALK tyrosine kinase receptor2.7.10.10.440
4lsl1YQGag-Pol polyprotein2.7.7.490.440