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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pmlANPUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pmlANPUncharacterized protein/1.000
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.549
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.532
2pmoHMDProtein kinase 7/0.528
4ii5ADPCyclin-dependent kinase 22.7.11.220.514
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.512
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.506
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.498
2pmnK51Protein kinase 7/0.497
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.497
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.494
2iw84SPCyclin-dependent kinase 22.7.11.220.493
3r9dX6BCyclin-dependent kinase 22.7.11.220.491
4bgg844Activin receptor type-12.7.11.300.491
4i3zADPCyclin-dependent kinase 22.7.11.220.488
4qnyANPMitogen activated protein kinase, putative/0.487
1jstATPCyclin-dependent kinase 22.7.11.220.485
2pz5ACPFibroblast growth factor receptor 2/0.484
5e92ANPTGF-beta receptor type-22.7.11.300.484
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.483
1qmzATPCyclin-dependent kinase 22.7.11.220.482
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.482
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.481
3mtfA3FActivin receptor type-12.7.11.300.481
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.480
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.479
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.478
4qmpDKISerine/threonine-protein kinase 242.7.11.10.477
4eomATPCyclin-dependent kinase 22.7.11.220.473
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.471
3dogNNNCyclin-dependent kinase 22.7.11.220.471
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
4eol1ROCyclin-dependent kinase 22.7.11.220.471
1oiyN41Cyclin-dependent kinase 22.7.11.220.470
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.469
3rak03ZCyclin-dependent kinase 22.7.11.220.468
1e9hINRCyclin-dependent kinase 22.7.11.220.467
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.467
2wotZZGTGF-beta receptor type-12.7.11.300.466
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.464
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.463
4eooATPCyclin-dependent kinase 22.7.11.220.463
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.462
4k33ACPFibroblast growth factor receptor 32.7.10.10.462
1nzfUPGDNA beta-glucosyltransferase/0.461
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.461
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.461
3gu7ADPDeath-associated protein kinase 12.7.11.10.461
3ral04ZCyclin-dependent kinase 22.7.11.220.461
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.460
2pzpACPFibroblast growth factor receptor 2/0.460
2qo9ANPEphrin type-A receptor 32.7.10.10.460
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.460
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.460
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.458
5dn3ATPAurora kinase A2.7.11.10.458
1di8DTQCyclin-dependent kinase 22.7.11.220.457
2gevCOKPantothenate kinase2.7.1.330.457
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.457
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.457
2w05FRTCyclin-dependent kinase 22.7.11.220.456
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.456
4fx360KCyclin-dependent kinase 22.7.11.220.456
2x1nX1NCyclin-dependent kinase 22.7.11.220.455
4eoi1ROCyclin-dependent kinase 22.7.11.220.455
4iirANPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.455
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.455
2uzbC75Cyclin-dependent kinase 22.7.11.220.454
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.454
1tvoFRZMitogen-activated protein kinase 12.7.11.240.453
3s1h56ZCyclin-dependent kinase 22.7.11.220.453
4eor4SPCyclin-dependent kinase 22.7.11.220.453
1j39UPGDNA beta-glucosyltransferase/0.452
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.452
2izrBRKCasein kinase I isoform gamma-32.7.11.10.452
2wihP48Cyclin-dependent kinase 22.7.11.220.452
3r73X87Cyclin-dependent kinase 22.7.11.220.452
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.452
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.451
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.451
4j97ACPFibroblast growth factor receptor 2/0.451
4qmlANPSerine/threonine-protein kinase 242.7.11.10.451
1h1pCMGCyclin-dependent kinase 22.7.11.220.450
3my5RFZCyclin-dependent kinase 22.7.11.220.450
5dnrATPAurora kinase A2.7.11.10.450
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.449
3clyACPFibroblast growth factor receptor 2/0.449
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.449
4xlvACPInsulin receptor2.7.10.10.449
1cm8ANPMitogen-activated protein kinase 12/0.448
1oi9N20Cyclin-dependent kinase 22.7.11.220.448
2py3ACPFibroblast growth factor receptor 2/0.448
2qoqANPEphrin type-A receptor 32.7.10.10.448
3oriAGSSerine/threonine protein kinase/0.448
4eos1ROCyclin-dependent kinase 22.7.11.220.448
4n6hEJ4Delta-type opioid receptor/0.448
4o1pANPRibonuclease L/0.448
2w2lNADD-mandelate dehydrogenase/0.447
3w33W19Epidermal growth factor receptor2.7.10.10.447
4oavACP2-5A-dependent ribonuclease3.1.260.447
4riyADPEpidermal growth factor receptor2.7.10.10.447
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.446
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.446
2pywADPMethylthioribose kinase2.7.1.1000.446
3poz03PEpidermal growth factor receptor2.7.10.10.446
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
1pkdUCNCyclin-dependent kinase 22.7.11.220.445
1v0oINRCell division control protein 2 homolog2.7.11.220.445
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.445
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.445
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.445
3qu0X40Cyclin-dependent kinase 22.7.11.220.445
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.445
4bbe3O4Tyrosine-protein kinase JAK2/0.445
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.445
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.445
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.444
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.444
3lq5SLQCyclin-dependent kinase 92.7.11.220.444
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.444
4dymIYZActivin receptor type-12.7.11.300.444
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.444
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4utdACPAurora kinase A2.7.11.10.444
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3s0o50ZCyclin-dependent kinase 22.7.11.220.443
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.443
1gy3ATPCyclin-dependent kinase 22.7.11.220.442
3qyw6PBMitogen-activated protein kinase 12.7.11.240.442
3ttjJBIMitogen-activated protein kinase 102.7.11.240.442
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
4gmy0X5Tyrosine-protein kinase JAK2/0.442
4h3qANPMitogen-activated protein kinase 12.7.11.240.442
4jr7GNPCasein kinase II subunit alpha2.7.11.10.442
1dawANPCasein kinase II subunit alpha2.7.11.10.441
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.441
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.441
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.441
4ek816KCyclin-dependent kinase 22.7.11.220.441
4fv9E71Mitogen-activated protein kinase 12.7.11.240.441
4ic7ANPMitogen-activated protein kinase 72.7.11.240.441
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.441
1j7uANPAminoglycoside 3'-phosphotransferase2.7.1.950.440
1lp4ANPCasein kinase II subunit alpha2.7.11.10.440
1ol5ADPAurora kinase A2.7.11.10.440
2b55D31Cyclin-dependent kinase 22.7.11.220.440
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2vu3LZECyclin-dependent kinase 22.7.11.220.440
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.440