Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2opbF21Phenylethanolamine N-methyltransferase2.1.1.28

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2opbF21Phenylethanolamine N-methyltransferase2.1.1.281.000
2onyTMJPhenylethanolamine N-methyltransferase2.1.1.280.710
2onzTMJPhenylethanolamine N-methyltransferase2.1.1.280.687
2g8nF83Phenylethanolamine N-methyltransferase2.1.1.280.630
2obfF83Phenylethanolamine N-methyltransferase2.1.1.280.615
2g72F21Phenylethanolamine N-methyltransferase2.1.1.280.527
2bf7HBIPteridine reductase 11.5.1.330.494
2cleF6FTryptophan synthase alpha chain/0.473
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.472
3pn1IVHDNA ligase/0.472
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.470
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.467
1be4PCGNucleoside diphosphate kinase A 22.7.4.60.466
1z6tADPApoptotic protease-activating factor 1/0.464
3i53SAH2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.464
4bufF36Tankyrase-22.4.2.300.464
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.462
3vf60H6Glucokinase2.7.1.20.461
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.460
1o6qR17Squalene--hopene cyclase4.2.1.1290.460
2yatEEUEstrogen receptor/0.460
4dhyS41Glucokinase2.7.1.20.460
1re0AFBADP-ribosylation factor 1/0.458
1re0AFBARF guanine-nucleotide exchange factor 1/0.458
3p9tTCLRepressor/0.458
1pd9CO4Dihydrofolate reductase1.5.1.30.456
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.455
3d2dRENReticuline oxidase1.21.3.30.455
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
1h36R88Squalene--hopene cyclase4.2.1.1290.454
2vz0D64Pteridine reductase/0.454
3s41S41Glucokinase2.7.1.20.453
4li81XQTankyrase-12.4.2.300.453
3lfeZ84Mitogen-activated protein kinase 14/0.452
4a86H35Major pollen allergen Bet v 1-A/0.452
1pf7IMHPurine nucleoside phosphorylase2.4.2.10.451
4hni16WCasein kinase I isoform epsilon2.7.11.10.451
3dejRXCCaspase-33.4.22.560.450
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.450
4jpg1OXPyruvate kinase PKM2.7.1.400.450
1kf6HQOFumarate reductase iron-sulfur subunit1.3.5.10.449
1kf6HQOFumarate reductase subunit C/0.449
1kf6HQOFumarate reductase subunit D/0.449
1yhoTRRDihydrofolate reductase1.5.1.30.449
2oz57XYUncharacterized protein/0.449
3aosJH2Hemolymph juvenile hormone binding protein/0.449
4amjCVDBeta-1 adrenergic receptor/0.449
4hkkAGITankyrase-22.4.2.300.449
4y6gF6FTryptophan synthase alpha chain/0.449
3a1l2CCCytochrome P450/0.448
1kmsLIHDihydrofolate reductase1.5.1.30.447
1s2g3D1Nucleoside 2-deoxyribosyltransferase/0.447
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.447
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1yryMSGPurine nucleoside phosphorylase2.4.2.10.447
2bfaCB3Pteridine reductase 11.5.1.330.447
3lm4HPXCatechol 2,3-dioxygenase/0.447
3qp8HL0Transcriptional activator, LuxR/UhpA family of regulators/0.447
3uph0C1Genome polyprotein2.7.7.480.447
4amiG90Beta-1 adrenergic receptor/0.447
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.446
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.446
3dlcSAMSAM (And some other nucleotide) binding motif:Generic methyltransferase/0.446
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
5fd8A5APutative carboxypeptidase yocD/0.446
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.445
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.445
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.445
4ax8ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.445
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2bktRPFRenin3.4.23.150.444
3llaACPMyosin heavy chain kinase A2.7.11.70.444
1qzzSAMAclacinomycin 10-hydroxylase RdmB4.1.10.443
1w7h3IPMitogen-activated protein kinase 14/0.443
1zg32HIIsoflavone 4'-O-methyltransferase/0.443
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4twnB96Ephrin type-A receptor 32.7.10.10.443
1kmvLIIDihydrofolate reductase1.5.1.30.442
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2x9vTMQPteridine reductase/0.442
3oadLPORenin3.4.23.150.442
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.442
4ddrMMVDihydrofolate reductase1.5.1.30.442
4iaq2GM5-hydroxytryptamine receptor 1B/0.442
1k9sFM2Purine nucleoside phosphorylase DeoD-type/0.441
4dscA8SAbscisic acid receptor PYL3/0.441
4e70N7IConiferyl alcohol 9-O-methyltransferase/0.441
5d6lCAUBeta-2 adrenergic receptor/0.441
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.440
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
4dvi2IWTankyrase-12.4.2.300.440