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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2harOCCVitamin D3 receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2harOCCVitamin D3 receptor/1.000
1ie9VDXVitamin D3 receptor/0.751
3kpzZNEVitamin D3 receptor/0.734
1s19MC9Vitamin D3 receptor/0.731
2hb7O1CVitamin D3 receptor/0.722
1s0zEB1Vitamin D3 receptor/0.711
1ie8KH1Vitamin D3 receptor/0.700
3m7rVDXVitamin D3 receptor/0.698
3w0c6DSVitamin D3 receptor/0.694
1rkhVD2Vitamin D3 receptor/0.693
1rk3VDXVitamin D3 receptor/0.687
1db1VDXVitamin D3 receptor/0.683
1rkgVD1Vitamin D3 receptor/0.679
4itfTFYVitamin D3 receptor/0.678
1txiTX5Vitamin D3 receptor/0.674
2zl9VDAVitamin D3 receptor/0.673
3vrvYSDVitamin D3 receptor/0.671
2hc4VDXVitamin D3 receptor A/0.670
4ia3BIVVitamin D3 receptor A/0.669
2hbhXE4Vitamin D3 receptor A/0.668
3w0yDS4Vitamin D3 receptor/0.668
4rupH97Vitamin D3 receptor A/0.668
4g1y0VOVitamin D3 receptor A/0.667
2zlcVDXVitamin D3 receptor/0.666
4g1d0VKVitamin D3 receptor A/0.666
2o4jVD4Vitamin D3 receptor/0.663
2o4rVD5Vitamin D3 receptor/0.663
3vt65YIVitamin D3 receptor/0.663
4ia1BIVVitamin D3 receptor A/0.661
2hasC3OVitamin D3 receptor/0.659
2zlaVDBVitamin D3 receptor/0.659
2hamC33Vitamin D3 receptor/0.656
3vt8YI3Vitamin D3 receptor/0.656
4fhh0U3Vitamin D3 receptor A/0.653
4ia7BIVVitamin D3 receptor A/0.653
3vt3VDXVitamin D3 receptor/0.652
2hcdBIVVitamin D3 receptor A/0.651
3dr1C5DVitamin D3 receptor A/0.651
4g1z0VPVitamin D3 receptor A/0.651
2hb8MVDVitamin D3 receptor/0.649
4fhi0S4Vitamin D3 receptor A/0.648
4g210VPVitamin D3 receptor A/0.647
3vt7VDXVitamin D3 receptor/0.646
4ia2BIVVitamin D3 receptor A/0.645
3w0jT08Vitamin D3 receptor/0.644
4g2h0VQVitamin D3 receptor A/0.644
3vrwYS5Vitamin D3 receptor/0.641
3vrtYS2Vitamin D3 receptor/0.640
3vruYS3Vitamin D3 receptor/0.636
3w0aDS5Vitamin D3 receptor/0.636
3vt5YI2Vitamin D3 receptor/0.635
3vt45YIVitamin D3 receptor/0.631
4g20484Vitamin D3 receptor A/0.631
4rujVDXVitamin D3 receptor A/0.631
3vt9YI4Vitamin D3 receptor/0.627
1rjkVDZVitamin D3 receptor/0.625
3vtbTKAVitamin D3 receptor/0.624
3w5rLOAVitamin D3 receptor/0.623
4ruoBIVVitamin D3 receptor A/0.622
3vtdTKDVitamin D3 receptor/0.621
4iteTEYVitamin D3 receptor/0.621
4q0a4OAVitamin D3 receptor A/0.619
3w0gW07Vitamin D3 receptor/0.609
3w0iO11Vitamin D3 receptor/0.608
3w5tLHPVitamin D3 receptor/0.607
3vtcTK3Vitamin D3 receptor/0.603
3a783EVVitamin D3 receptor/0.598
3w0hW12Vitamin D3 receptor/0.597
3w5p4OAVitamin D3 receptor/0.594
3w5q3KLVitamin D3 receptor/0.575
4g2i0VQVitamin D3 receptor/0.509
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.471
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.465
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.461
2ath3EAPeroxisome proliferator-activated receptor gamma/0.460
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.460
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
3iupNDPPossible NADH oxidoreductase/0.460
4nxuADPMitochondrial dynamics protein MID51/0.460
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.459
2ftoCB3Thymidylate synthase/0.459
2nnhREACytochrome P450 2C8/0.459
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
3zep1NXTyrosine-protein kinase JAK32.7.10.20.458
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.457
2zb3NDPProstaglandin reductase 21.3.1.480.457
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
4ambDUDPutative glycosyl transferase/0.456
2fy5SOPCholine O-acetyltransferase2.3.1.60.455
2go4TUXUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.454
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.454
2vnaNAPProstaglandin reductase 21.3.1.480.454
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.453
3l0lHC3Nuclear receptor ROR-gamma/0.453
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.453
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.453
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
3b70NAPEnoyl reductase LovC10.452
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.452
1k74544Peroxisome proliferator-activated receptor gamma/0.451
2w4qCBWProstaglandin reductase 21.3.1.480.451
4l9kEHFSerum albumin/0.451
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.450
3mnrSD1Heat shock protein HSP 90-alpha/0.450
4awo99BHeat shock protein HSP 90-alpha/0.450
1blzACVIsopenicillin N synthase1.21.3.10.449
1pjkANPCasein kinase II subunit alpha2.7.11.10.449
1uyfPU1Heat shock protein HSP 90-alpha/0.449
2ykjYKJHeat shock protein HSP 90-alpha/0.449
1pr9NAPL-xylulose reductase1.1.1.100.448
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.448
3stuDK3Methylketone synthase I/0.448
3tqhNDPQuinone oxidoreductase/0.448
3w32W32Epidermal growth factor receptor2.7.10.10.448
3w33W19Epidermal growth factor receptor2.7.10.10.448
4a6bQG8Gag-Pol polyprotein3.4.23.160.448
4b7xNAPProbable oxidoreductase/0.448
4l8u9AZSerum albumin/0.448
4o701QKBromodomain-containing protein 4/0.448
2z3uCRRCytochrome P450/0.447
3u4uLNHCasein kinase II subunit alpha2.7.11.10.447
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.447
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.447
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.446
1jipKTN6-deoxyerythronolide B hydroxylase/0.446
4gevCB3Thymidylate synthase/0.446
5itzLOCTubulin beta-2B chain/0.446
1k7l544Peroxisome proliferator-activated receptor alpha/0.445
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.445
2y05NAPProstaglandin reductase 1/0.445
4b7sQLECytochrome P450 monooxygenase PikC/0.445
3k9uACOSpermidine N(1)-acetyltransferase/0.444
3poz03PEpidermal growth factor receptor2.7.10.10.444
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.443
3nx4NAPPutative oxidoreductase/0.443
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
1nq7ARLNuclear receptor ROR-beta/0.442
1sn5T3Transthyretin/0.442
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.442
2o7pNAPRiboflavin biosynthesis protein RibD/0.442
1m13HYFNuclear receptor subfamily 1 group I member 2/0.441
1yb5NAPQuinone oxidoreductase1.6.5.50.441
2hw2RFPRifampin ADP-ribosyl transferase/0.441
2j8zNAPQuinone oxidoreductase PIG310.441
2ykeYKEHeat shock protein HSP 90-alpha/0.441
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
4a6cQG9Gag-Pol polyprotein3.4.23.160.441
1p8dCO1Oxysterols receptor LXR-beta/0.440
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.440
2zb8IMNProstaglandin reductase 21.3.1.480.440
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3tdaPN0Cytochrome P450 2D6/0.440
4tuvCPZCytochrome P450 1191.140.440