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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gr0FADFerredoxin reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gr0FADFerredoxin reductase/1.000
4h4vFADBiphenyl dioxygenase ferredoxin reductase subunit/0.807
2gqwFADFerredoxin reductase/0.729
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.695
2gr1FADFerredoxin reductase/0.692
4h4rFADBiphenyl dioxygenase ferredoxin reductase subunit/0.673
1d7yFADFerredoxin reductase/0.672
4h4tFADBiphenyl dioxygenase ferredoxin reductase subunit/0.669
4h4uFADBiphenyl dioxygenase ferredoxin reductase subunit/0.661
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.639
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.607
4h4wFADBiphenyl dioxygenase ferredoxin reductase subunit/0.595
4h4pFADBiphenyl dioxygenase ferredoxin reductase subunit/0.591
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.558
5fs6FADApoptosis-inducing factor 1, mitochondrial1.1.10.551
5fs9FADApoptosis-inducing factor 1, mitochondrial1.1.10.547
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.538
4bv6FADApoptosis-inducing factor 1, mitochondrial1.1.10.520
4h4yFADBiphenyl dioxygenase ferredoxin reductase subunit/0.520
1m6iFADApoptosis-inducing factor 1, mitochondrial1.1.10.517
5fs8FADApoptosis-inducing factor 1, mitochondrial1.1.10.515
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.512
4emjFADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.505
2yvjFADFerredoxin reductase/0.490
3gd3FADApoptosis-inducing factor 1, mitochondrial1.1.10.490
2cduFADNADH oxidase/0.487
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.483
2eq9FADDihydrolipoyl dehydrogenase/0.481
3cgcFADCoenzyme A disulfide reductase/0.481
3lxdFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.481
1nhsFADNADH peroxidase1.11.1.10.477
1f3pFADFerredoxin reductase/0.476
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.476
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.473
3lb8FADPutidaredoxin reductase1.18.1.50.472
1nhpFADNADH peroxidase1.11.1.10.471
3ictFADCoenzyme A disulfide reductase/0.468
1nhqFADNADH peroxidase1.11.1.10.467
1zk7FADMercuric reductase1.16.1.10.465
2eq6FADDihydrolipoyl dehydrogenase/0.461
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.460
1joaFADNADH peroxidase1.11.1.10.457
3ishFADThioredoxin reductase1.8.1.90.457
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.457
1f8wFADNADH peroxidase1.11.1.10.454
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.452
3cgbFADCoenzyme A disulfide reductase/0.450
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.449
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.448
3ladFADDihydrolipoyl dehydrogenase/0.447
3icsFADCoenzyme A disulfide reductase/0.445
2eq8FADDihydrolipoyl dehydrogenase/0.444
1zx9FADMercuric reductase1.16.1.10.442
2r9zFADGlutathione amide reductase/0.442
2yquFADDihydrolipoyl dehydrogenase/0.440