sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2duz | ZST | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.792 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.736 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.715 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.710 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.701 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.700 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.696 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.683 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.683 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.681 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.680 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.680 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.673 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.659 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.656 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.653 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.642 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.642 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.639 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.638 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.638 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.637 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.633 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.631 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.624 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.619 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.615 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.614 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.612 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.607 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.604 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.604 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.600 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.598 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.592 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.587 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.587 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.584 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.581 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.575 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.571 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.564 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.562 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.560 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.557 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.556 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.553 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.547 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.546 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.545 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.544 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.535 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.530 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.525 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.510 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.508 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.507 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.498 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.489 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.479 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.477 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.476 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.474 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.472 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.472 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.471 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.470 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.470 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.469 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.467 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.465 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.464 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.463 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.462 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.460 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.459 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.458 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.458 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.457 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.457 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.457 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.456 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.456 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.456 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.456 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.455 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.455 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.455 | |
| 2hzq | STR | Apolipoprotein D | / | 0.454 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.454 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.453 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.453 | |
| 4phl | PIL | Phosphodiesterase | / | 0.453 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.453 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.452 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.452 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.452 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.452 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.452 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.450 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.450 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.449 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 4kxj | P34 | Nucleoprotein | / | 0.449 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.448 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.448 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.448 | |
| 4kmz | FOL | Folate receptor beta | / | 0.448 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.446 | |
| 4e2y | JHZ | Methyltransferase | / | 0.446 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.446 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.445 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.445 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.445 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.445 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.445 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.444 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.444 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.443 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.443 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.443 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.442 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.442 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.442 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.441 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.441 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.441 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.441 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.440 | |
| 4yfy | 0FX | VioF | / | 0.440 |