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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]/1.000
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.643
3nhfVVVRibosyldihydronicotinamide dehydrogenase [quinone]/0.641
3ox1695Ribosyldihydronicotinamide dehydrogenase [quinone]/0.641
3uxhUXHRibosyldihydronicotinamide dehydrogenase [quinone]/0.633
3nhkVAPRibosyldihydronicotinamide dehydrogenase [quinone]/0.630
3uxe465Ribosyldihydronicotinamide dehydrogenase [quinone]/0.625
4gqiM49Ribosyldihydronicotinamide dehydrogenase [quinone]/0.623
3nhyA7BRibosyldihydronicotinamide dehydrogenase [quinone]/0.622
4zvmDM2Ribosyldihydronicotinamide dehydrogenase [quinone]/0.614
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.609
3owxXRARibosyldihydronicotinamide dehydrogenase [quinone]/0.607
4fgj1PQRibosyldihydronicotinamide dehydrogenase [quinone]/0.607
3nhlYTRRibosyldihydronicotinamide dehydrogenase [quinone]/0.601
3nhpHGZRibosyldihydronicotinamide dehydrogenase [quinone]/0.598
3nhjA2ZRibosyldihydronicotinamide dehydrogenase [quinone]/0.593
2qmzLDPRibosyldihydronicotinamide dehydrogenase [quinone]/0.590
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.589
4gr9372Ribosyldihydronicotinamide dehydrogenase [quinone]/0.585
3nhrRZWRibosyldihydronicotinamide dehydrogenase [quinone]/0.583
3nfrEWQRibosyldihydronicotinamide dehydrogenase [quinone]/0.581
4qohSTLRibosyldihydronicotinamide dehydrogenase [quinone]/0.575
3nhuM42Ribosyldihydronicotinamide dehydrogenase [quinone]/0.567
3nhwZXZRibosyldihydronicotinamide dehydrogenase [quinone]/0.566
3ox279XRibosyldihydronicotinamide dehydrogenase [quinone]/0.548
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.539
3gamMXXRibosyldihydronicotinamide dehydrogenase [quinone]/0.518
1xi2CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.517
1qr2FADRibosyldihydronicotinamide dehydrogenase [quinone]/0.513
3g5mFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.502
4zvnFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.484
4zvlFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.474
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.465
4pkl1GHUncharacterized protein/0.463
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA23.6.30.461
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA1/0.461
1s7gNADNAD-dependent protein deacylase 2/0.460
4eb4D16Thymidylate synthase2.1.1.450.455
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.454
1s3vTQDDihydrofolate reductase1.5.1.30.453
3pm1ETHTH-type transcriptional regulator QacR/0.453
3v94WYQPhosphodiesterase/0.453
1k7fIAVTryptophan synthase alpha chain/0.452
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.452
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.451
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.449
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.448
3ha3SAHHydroxymycolate synthase MmaA42.1.10.447
4jvmXDIEstrogen sulfotransferase2.8.2.40.447
4jvnYUGEstrogen sulfotransferase2.8.2.40.446
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
1s3uTQDDihydrofolate reductase1.5.1.30.444
2bpoFADNADPH--cytochrome P450 reductase/0.444
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
1kkq471Peroxisome proliferator-activated receptor alpha/0.443
1sjwNGVNogalonic acid methyl ester cyclase/0.443
1x8lOXRRetinol dehydratase/0.443
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.443
4jlj1NMDeoxycytidine kinase2.7.1.740.443
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1mvtDTMDihydrofolate reductase1.5.1.30.441
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3k7tFAD6-hydroxy-L-nicotine oxidase/0.441
4dymIYZActivin receptor type-12.7.11.300.441
4hni16WCasein kinase I isoform epsilon2.7.11.10.441
4qoeFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3pqbVGPPutative oxidoreductase/0.440
3s7a684Dihydrofolate reductase1.5.1.30.440
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.440