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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2bxgIBPSerum albumin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2bxgIBPSerum albumin/1.000
2bxe1FLSerum albumin/0.613
4zbrNPSSerum albumin/0.595
4ot2NPSSerum albumin/0.592
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.493
1ictT44Transthyretin/0.485
4ubsDIFPentalenic acid synthase1.14.15.110.481
3clyACPFibroblast growth factor receptor 2/0.480
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.480
1snyNAPLD36273p/0.477
3nwyGTPUridylate kinase/0.477
4b8zNAPGDP-L-fucose synthase1.1.1.2710.477
3tdl11DSerum albumin/0.473
3zcw4A2Kinesin-like protein KIF11/0.473
3k30ADPHistamine dehydrogenase/0.472
1ee0CAA2-pyrone synthase/0.470
2bxiAZQSerum albumin/0.469
1oaaNAPSepiapterin reductase1.1.1.1530.468
2pmdGNPTranslation initiation factor 2 subunit gamma/0.468
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.468
2p33J07Mitogen-activated protein kinase 102.7.11.240.467
3gy0NAPNAD(P)-dependent oxidoreductase/0.467
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.466
4xgxADPFAD:protein FMN transferase/0.466
3lu7IPXSerum albumin/0.465
4b8wNAPGDP-L-fucose synthase1.1.1.2710.465
4fryNADPutative signal-transduction protein with CBS domains/0.465
4rphFADUDP-galactopyranose mutase5.4.99.90.465
2e2qADPATP-dependent hexokinase/0.464
3f1kNAPUncharacterized oxidoreductase YciK10.464
3orpAGSSerine/threonine protein kinase/0.463
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.463
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.462
4jl5ADPAdenylate kinase/0.462
1j39UPGDNA beta-glucosyltransferase/0.461
4bcmT7ZCyclin-dependent kinase 22.7.11.220.461
3opdHIEHeat shock protein 83/0.460
2ya3J7V5'-AMP-activated protein kinase subunit gamma-1/0.459
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.459
3qrwNDPPutative ketoacyl reductase1.3.10.459
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.459
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.459
3tk3CPZCytochrome P450 2B41.14.14.10.458
4ctaATPCinA-like protein/0.458
4nmdFDABifunctional protein PutA/0.458
3igoANPCalmodulin-domain protein kinase 1, putative/0.457
1h0w207Cyclin-dependent kinase 22.7.11.220.456
3h0sB38Acetyl-CoA carboxylase/0.456
4b4dFADFerredoxin-NADP reductase/0.456
1tdnFADL-amino-acid oxidase1.4.3.20.455
3eqlMXPDNA-directed RNA polymerase subunit beta/0.455
3eqlMXPDNA-directed RNA polymerase subunit beta'/0.455
3g6wGTPUracil phosphoribosyltransferase2.4.2.90.455
4gapFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.455
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.455
4jia1K3Tyrosine-protein kinase JAK2/0.455
5idwNAPShort-chain dehydrogenase/reductase SDR/0.455
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.454
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.454
4mobCOAAcyl-coenzyme A thioesterase 123.1.2.10.454
1ipeNDPTropinone reductase 21.1.1.2360.453
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.453
1w87NAPFerredoxin--NADP reductase1.18.1.20.453
4dpmCOAMalonyl-CoA reductase1.2.1.750.453
4j7xNAPSepiapterin reductase1.1.1.1530.453
1xq6NAPUncharacterized protein At5g02240/0.452
3adaNADSubunit alpha of sarocosine oxidase/0.452
3hdyFADUDP-galactopyranose mutase/0.452
1agnNADAlcohol dehydrogenase class 4 mu/sigma chain1.1.1.10.451
1glbADPGlycerol kinase/0.451
1heuNADAlcohol dehydrogenase E chain1.1.1.10.451
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.451
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
2w2lNADD-mandelate dehydrogenase/0.451
3ak4NADNADH-dependent quinuclidinone reductase/0.451
3c50ADPRhodopsin kinase/0.451
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.451
3vspEK8Peroxisome proliferator-activated receptor gamma/0.451
3zc3NAPFerredoxin--NADP reductase1.18.1.20.451
4bk3FADProbable salicylate monooxygenase/0.451
1kvoOAPPhospholipase A2, membrane associated/0.450
2bx8AZQSerum albumin/0.450
3gc9B45Mitogen-activated protein kinase 112.7.11.240.450
3glmCOOGlutaconyl-CoA decarboxylase alpha subunit/0.450
4hee14RPeroxisome proliferator-activated receptor gamma/0.450
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.450
2dbrNAPGlyoxylate reductase1.1.1.260.449
2npaMMBPeroxisome proliferator-activated receptor alpha/0.449
4j7uNAPSepiapterin reductase1.1.1.1530.449
4l9y1VUL-malyl-CoA/beta-methylmalyl-CoA lyase4.1.3.240.449
4pytFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.449
4rpgFADUDP-galactopyranose mutase5.4.99.90.449
5itzLOCTubulin beta-2B chain/0.449
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.448
1ybmNAPUncharacterized protein At5g02240/0.448
2a41ATPActin, alpha skeletal muscle/0.448
2q6cHR13-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.448
3i99FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.448
4a99FADTetX family tetracycline inactivation enzyme/0.448
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.448
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.448
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.447
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.447
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.447
3ictCOACoenzyme A disulfide reductase/0.447
4btjATPTau-tubulin kinase 12.7.11.10.447
4fk1FADPutative thioredoxin reductase/0.447
4ix5ANPUncharacterized protein/0.447
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.447
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.447
1h6vNDPThioredoxin reductase 1, cytoplasmic1.8.1.90.446
1jx0DFVChalcone--flavonone isomerase 15.5.1.60.446
1ywrLI9Mitogen-activated protein kinase 14/0.446
2obyNAPQuinone oxidoreductase PIG310.446
2qa2FADPolyketide oxygenase CabE/0.446
3h0aD30Peroxisome proliferator-activated receptor gamma/0.446
3lfbZ87Mitogen-activated protein kinase 14/0.446
4dc1NDPPutative ketoacyl reductase1.3.10.446
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1b8sFADCholesterol oxidase1.1.3.60.445
2zbzVDXVitamin D3 dihydroxylase/0.445
3cwkREACellular retinoic acid-binding protein 2/0.445
4j95ACPFibroblast growth factor receptor 2/0.445
4jloADPAdenylate kinase/0.445
4xwrFADCholesterol oxidase1.1.3.60.445
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.445
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.444
2cduFADNADH oxidase/0.444
2izrBRKCasein kinase I isoform gamma-32.7.11.10.444
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.444
3hdyFDAUDP-galactopyranose mutase/0.444
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.444
3pjuC2EDiguanylate cyclase/phosphodiesterase/0.444
3wdsNADNADH-dependent quinuclidinone reductase/0.444
4c57FEFCyclin-G-associated kinase2.7.11.10.444
4e730NRMitogen-activated protein kinase 82.7.11.240.444
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.444
4o0uADNAurora kinase A2.7.11.10.444
5f1cATPUncharacterized protein/0.444
2bd0NAPSepiapterin reductase/0.443
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4hwkNAPSepiapterin reductase1.1.1.1530.443
4tm0FADKtzI/0.443
4xxgFADCholesterol oxidase1.1.3.60.443
5kf8ACOPredicted acetyltransferase/0.443
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.442
3bosCDPRegulatory inactivation of DnaA Hda protein/0.442
3p7nFMNLight-activated DNA-binding protein EL222/0.442
3pjtC2EDiguanylate cyclase/phosphodiesterase/0.442
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
4j99ACPFibroblast growth factor receptor 2/0.442
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.442
5av2KMPDeath-associated protein kinase 12.7.11.10.442
1adcPADAlcohol dehydrogenase E chain1.1.1.10.441
1d7yFADFerredoxin reductase/0.441
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.441
3ntdCOAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.441
3qqs17CAnthranilate phosphoribosyltransferase/0.441
3wd7COAAcridone synthase/0.441
4bbe3O4Tyrosine-protein kinase JAK2/0.441
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.441
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4ele31IDihydrofolate reductase/0.441
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.441
4hnf16WCasein kinase I isoform delta2.7.11.10.441
5g3sFDAFlavin-dependent L-tryptophan oxidase VioA/0.441
1nmdATPMajor actin/0.440
1owpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.440
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.440
1yreCOAUncharacterized protein/0.440
2cahNDPCatalase1.11.1.60.440
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.440
2j7t274Serine/threonine-protein kinase 102.7.11.10.440
3cgfJNFMitogen-activated protein kinase 102.7.11.240.440
3zsi52PMitogen-activated protein kinase 14/0.440
4elg52JDihydrofolate reductase/0.440
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.440
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.440
4z34ON7Lysophosphatidic acid receptor 1/0.440