sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 1.000 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.739 | |
| 3nhy | A7B | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.633 | |
| 3nhk | VAP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.615 | |
| 3nhf | VVV | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.612 | |
| 4zvm | DM2 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.602 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.593 | |
| 3nhw | ZXZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.569 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.566 | |
| 2bzs | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.555 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.554 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.550 | |
| 4qoh | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.549 | |
| 4gqi | M49 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.547 | |
| 3nhj | A2Z | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.544 | |
| 3uxe | 465 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.541 | |
| 4fgj | 1PQ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.537 | |
| 3owx | XRA | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.532 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.529 | |
| 3nfr | EWQ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.522 | |
| 3nhr | RZW | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.512 | |
| 3nhl | YTR | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.510 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.509 | |
| 3ox2 | 79X | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.498 | |
| 4gr9 | 372 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.489 | |
| 3gam | MXX | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.476 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3nhu | M42 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.467 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.460 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1xi2 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.459 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1ja1 | FAD | NADPH--cytochrome P450 reductase | / | 0.457 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1ppj | ANY | Cytochrome b | / | 0.451 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.449 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.447 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.447 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.446 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.446 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.446 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.446 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.445 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.445 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.444 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.444 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.443 | |
| 4xwt | U5P | Ribonuclease J | / | 0.443 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.442 | |
| 2gpj | FAD | Siderophore-interacting protein | / | 0.441 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.440 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.440 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.440 |