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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/1.000
3nhpHGZRibosyldihydronicotinamide dehydrogenase [quinone]/0.642
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.636
3nhlYTRRibosyldihydronicotinamide dehydrogenase [quinone]/0.603
3nhfVVVRibosyldihydronicotinamide dehydrogenase [quinone]/0.602
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.598
3nhjA2ZRibosyldihydronicotinamide dehydrogenase [quinone]/0.584
3nhkVAPRibosyldihydronicotinamide dehydrogenase [quinone]/0.581
3ox1695Ribosyldihydronicotinamide dehydrogenase [quinone]/0.574
4fgj1PQRibosyldihydronicotinamide dehydrogenase [quinone]/0.571
3nhyA7BRibosyldihydronicotinamide dehydrogenase [quinone]/0.570
3ox279XRibosyldihydronicotinamide dehydrogenase [quinone]/0.570
4zvmDM2Ribosyldihydronicotinamide dehydrogenase [quinone]/0.570
4gqiM49Ribosyldihydronicotinamide dehydrogenase [quinone]/0.569
4qohSTLRibosyldihydronicotinamide dehydrogenase [quinone]/0.564
4gr9372Ribosyldihydronicotinamide dehydrogenase [quinone]/0.562
3owxXRARibosyldihydronicotinamide dehydrogenase [quinone]/0.559
1xi2CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.558
3uxhUXHRibosyldihydronicotinamide dehydrogenase [quinone]/0.552
3nhrRZWRibosyldihydronicotinamide dehydrogenase [quinone]/0.551
3nhuM42Ribosyldihydronicotinamide dehydrogenase [quinone]/0.544
2qmzLDPRibosyldihydronicotinamide dehydrogenase [quinone]/0.540
3uxe465Ribosyldihydronicotinamide dehydrogenase [quinone]/0.528
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.524
3nhwZXZRibosyldihydronicotinamide dehydrogenase [quinone]/0.524
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.511
4zvnFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.507
3nfrEWQRibosyldihydronicotinamide dehydrogenase [quinone]/0.497
3gamMXXRibosyldihydronicotinamide dehydrogenase [quinone]/0.474
3v94WYQPhosphodiesterase/0.465
1mvsDTMDihydrofolate reductase1.5.1.30.461
3g5mFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.461
2fs4PZ1Renin3.4.23.150.460
2f3815MAldo-keto reductase family 1 member C3/0.454
1drfFOLDihydrofolate reductase1.5.1.30.453
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
4irnFADAnaB/0.450
4qa0SHHHistone deacetylase 83.5.1.980.450
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.448
4qoeFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.448
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.446
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.445
2wjoQUDBeta-secretase 13.4.23.460.444
3i7vB4PAP4A hydrolase/0.444
4qofFMNRibosyldihydronicotinamide dehydrogenase [quinone]/0.444
3c1oNAPEugenol synthase/0.443
3g6zA7TRenin3.4.23.150.443
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.442
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
1ry0PG2Aldo-keto reductase family 1 member C3/0.442
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
4iarERM5-hydroxytryptamine receptor 1B/0.442
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
4rvgTYDD-mycarose 3-C-methyltransferase/0.440