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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rx1NAPDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1rx1NAPDihydrofolate reductase1.5.1.31.000
1ia1NDPDihydrofolate reductase1.5.1.30.644
3qlsNDPDihydrofolate reductase1.5.1.30.630
3qlrNDPDihydrofolate reductase1.5.1.30.614
1drhNAPDihydrofolate reductase1.5.1.30.606
1ai9NDPDihydrofolate reductase1.5.1.30.596
1m78NDPDihydrofolate reductase1.5.1.30.596
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.577
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.575
2cig1DGDihydrofolate reductase1.5.1.30.573
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.572
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.570
1dr3TAPDihydrofolate reductase1.5.1.30.569
1dr2TAPDihydrofolate reductase1.5.1.30.568
2w3bNDPDihydrofolate reductase1.5.1.30.555
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.553
4m6jNDPDihydrofolate reductase1.5.1.30.553
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.552
5eccNAPDehydrofolate reductase type I/0.552
1dr5NAPDihydrofolate reductase1.5.1.30.546
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.545
3nxxNDPDihydrofolate reductase1.5.1.30.544
3tqaNDPDihydrofolate reductase/0.538
3d84NDPDihydrofolate reductase1.5.1.30.537
1rx8FOLDihydrofolate reductase1.5.1.30.530
1ia4TQ6Dihydrofolate reductase1.5.1.30.525
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.513
1tehNADAlcohol dehydrogenase class-31.1.1.10.501
4gl4NAIAlcohol dehydrogenase class-3/0.500
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.491
4jjiNADAlcohol dehydrogenase class-3/0.490
1e3eNAIAlcohol dehydrogenase 41.1.1.10.488
1ia3TQ5Dihydrofolate reductase1.5.1.30.488
2w9hTOPDihydrofolate reductase1.5.1.30.480
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.475
3b6zCO7Enoyl reductase LovC10.464
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.464
4bfxZVXPantothenate kinase2.7.1.330.463
5d3qGDPDynamin-13.6.5.50.462
1mp0NADAlcohol dehydrogenase class-31.1.1.10.461
2fzwNADAlcohol dehydrogenase class-31.1.1.10.461
1y0s331Peroxisome proliferator-activated receptor delta/0.459
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.457
1u71MXADihydrofolate reductase1.5.1.30.456
5jjsSAHGenome polyprotein/0.455
1rneC60Renin3.4.23.150.454
3lqfNADGalactitol dehydrogenase/0.454
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.453
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1mjbACOHistone acetyltransferase ESA1/0.452
2gjlFMNNitronate monooxygenase1.13.12.160.452
4z24FADPutative GMC-type oxidoreductase R13510.451
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
1qorNDPQuinone oxidoreductase 1/0.448
2a94AP0L-lactate dehydrogenase1.1.1.270.448
3nga3NGCasein kinase II subunit alpha2.7.11.10.448
3oafOAGDihydrofolate reductase1.5.1.30.448
4a83DXCMajor pollen allergen Bet v 1-A/0.448
4nxuADPMitochondrial dynamics protein MID51/0.448
3ukoNADAlcohol dehydrogenase class-3/0.447
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3toxNAPPutative oxidoreductase/0.446
3u9eCOALmo1369 protein/0.446
4ejmNAPPutative zinc-binding dehydrogenase/0.446
4q71FADBifunctional protein PutA/0.446
5jscFADPutative acyl-CoA dehydrogenase/0.446
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.445
2gvdFKPAdenylate cyclase type 2/0.445
2gvdFKPAdenylate cyclase type 5/0.445
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.445
4q73FADBifunctional protein PutA/0.445
1geuFADGlutathione reductase1.8.1.70.444
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1t2cNAIL-lactate dehydrogenase1.1.1.270.444
1geeNADGlucose 1-dehydrogenase1.1.1.470.443
1j49NADD-lactate dehydrogenase1.1.1.280.443
2w06FRVCyclin-dependent kinase 22.7.11.220.443
4l0qNADAlcohol dehydrogenase class-3/0.443
1fy7COAHistone acetyltransferase ESA1/0.442
1gcoNADGlucose 1-dehydrogenase1.1.1.470.442
2dgnDOIAdenylosuccinate synthetase isozyme 1/0.442
3qvpFADGlucose oxidase1.1.3.40.442
4q72FADBifunctional protein PutA/0.442
1f8fNADBenzyl alcohol dehydrogenase/0.441
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.441
3a1nNADNDP-sugar epimerase/0.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.441
1ma0NADAlcohol dehydrogenase class-31.1.1.10.440
3pwwROCEndothiapepsin3.4.23.220.440
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.440
4o1mNADEnoyl-acyl carrier reductase/0.440
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440