Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1pzgA3DLactate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1pzgA3DLactate dehydrogenase/1.000
1pzfA3DLactate dehydrogenase/0.689
1t2dNADL-lactate dehydrogenase1.1.1.270.628
1sowNADL-lactate dehydrogenase1.1.1.270.624
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.618
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.614
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.602
2a92NAIL-lactate dehydrogenase/0.590
2aa3AP0L-lactate dehydrogenase/0.589
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.583
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.563
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.560
5a1tNAIL-lactate dehydrogenase/0.546
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.542
1ie3NADMalate dehydrogenase/0.541
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.541
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.535
4ajo88NL-lactate dehydrogenase A chain1.1.1.270.523
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.516
1zemNADXylitol dehydrogenase/0.506
4oknNAIL-lactate dehydrogenase A chain1.1.1.270.501
1h2bNAJNAD-dependent alcohol dehydrogenase/0.500
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.499
1pzhNADLactate dehydrogenase/0.492
2vhvNAIAlanine dehydrogenase1.4.1.10.491
4jjiNADAlcohol dehydrogenase class-3/0.485
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.485
4dlbNADS-(hydroxymethyl)glutathione dehydrogenase/0.480
1lluNADAlcohol dehydrogenase/0.479
1adcPADAlcohol dehydrogenase E chain1.1.1.10.478
1yqdNAPSinapyl alcohol dehydrogenase/0.477
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.477
3a1nNADNDP-sugar epimerase/0.477
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.476
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.475
4lcjNADC-terminal-binding protein 2/0.475
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.474
4c4oNADSADH/0.474
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.473
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.473
2jhfNADAlcohol dehydrogenase E chain1.1.1.10.472
1r37NADNAD-dependent alcohol dehydrogenase1.1.1.10.471
4gl4NAIAlcohol dehydrogenase class-3/0.470
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.469
1adbCNDAlcohol dehydrogenase E chain1.1.1.10.467
5lc1NADL-threonine 3-dehydrogenase/0.467
1yqxNAPSinapyl alcohol dehydrogenase/0.465
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.465
5cdsNAJAlcohol dehydrogenase E chain1.1.1.10.464
1ma0NADAlcohol dehydrogenase class-31.1.1.10.463
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.463
3jv7NADSecondary alcohol dehydrogenase/0.463
1a71NADAlcohol dehydrogenase E chain1.1.1.10.462
1u3vNADAlcohol dehydrogenase 1B1.1.1.10.462
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.461
4gh5NADShort-chain dehydrogenase/reductase SDR/0.461
1g1aNADdTDP-glucose 4,6-dehydratase/0.460
1mg5NAIAlcohol dehydrogenase1.1.1.10.460
3ggoNAIPrephenate dehydrogenase/0.460
1f8fNADBenzyl alcohol dehydrogenase/0.459
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.459
5envNADAlcohol dehydrogenase 11.1.1.10.459
3a4vNADNDP-sugar epimerase/0.458
1agnNADAlcohol dehydrogenase class 4 mu/sigma chain1.1.1.10.457
2xaaNADSecondary alcohol dehydrogenase/0.457
3aw9NADNAD-dependent epimerase/dehydratase/0.457
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.454
4w6z8IDAlcohol dehydrogenase 11.1.1.10.454
2gsdNADFormate dehydrogenase/0.453
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.453
1e3lNADAlcohol dehydrogenase 41.1.1.10.452
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.452
3wmxNADNAD dependent epimerase/dehydratase/0.452
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.452
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.452
5jy1NADPutative short-chain dehydrogenase/reductase/0.452
2vhxNADAlanine dehydrogenase1.4.1.10.451
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.450
1hszNADAlcohol dehydrogenase 1B1.1.1.10.450
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.450
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.448
2y05NAPProstaglandin reductase 1/0.447
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.446
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.446
2vhzNAIAlanine dehydrogenase1.4.1.10.445
4nbwNADShort-chain dehydrogenase/reductase SDR/0.445
1hldNADAlcohol dehydrogenase E chain1.1.1.10.444
2omeNADC-terminal-binding protein 2/0.442
2zb3NDPProstaglandin reductase 21.3.1.480.442
3abiNADUncharacterized protein/0.442
4cpdNADAlcohol dehydrogenase/0.442
4egbNADdTDP-glucose 4,6-dehydratase/0.441
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.441
5jlaNADPutative short-chain dehydrogenase/reductase/0.441
1pj3NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.440
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.440