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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1m2pHNACasein kinase II subunit alpha2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1m2pHNACasein kinase II subunit alpha2.7.11.11.000
4anmWULCasein kinase II subunit alpha2.7.11.10.584
2pvhP19Casein kinase II subunit alpha2.7.11.10.580
1dawANPCasein kinase II subunit alpha2.7.11.10.560
1dayGNPCasein kinase II subunit alpha2.7.11.10.542
2pvlP55Casein kinase II subunit alpha2.7.11.10.532
4dgnLU2Casein kinase II subunit alpha2.7.11.10.532
2pvnP63Casein kinase II subunit alpha2.7.11.10.524
3be9P04Casein kinase II subunit alpha2.7.11.10.516
1om1IQACasein kinase II subunit alpha2.7.11.10.505
1lp4ANPCasein kinase II subunit alpha2.7.11.10.501
2pvmP29Casein kinase II subunit alpha2.7.11.10.493
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.491
4jr7GNPCasein kinase II subunit alpha2.7.11.10.490
5cvfATPCasein kinase II subunit alpha2.7.11.10.487
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.482
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.481
4lfiGNPCasein kinase II subunit alpha2.7.11.10.480
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.479
3at4CCKCasein kinase II subunit alpha2.7.11.10.477
2yaaATPDeath-associated protein kinase 2/0.472
4hvi19STyrosine-protein kinase JAK32.7.10.20.472
5cnoANPEpidermal growth factor receptor2.7.10.10.471
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.470
4hge15VTyrosine-protein kinase JAK2/0.469
5cvhADPCasein kinase II subunit alpha2.7.11.10.469
3at3ATKCasein kinase II subunit alpha2.7.11.10.466
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.464
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.463
3lltANPProtein serine/threonine kinase-1/0.462
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.462
5av2KMPDeath-associated protein kinase 12.7.11.10.462
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.461
3u4uLNHCasein kinase II subunit alpha2.7.11.10.460
4ix6ADPUncharacterized protein/0.460
1m2rMNYCasein kinase II subunit alpha2.7.11.10.457
3q9xEMOCasein kinase II subunit alpha2.7.11.10.456
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4aqc88ATyrosine-protein kinase JAK2/0.455
5cnnANPEpidermal growth factor receptor2.7.10.10.455
3nszANPCasein kinase II subunit alpha2.7.11.10.454
2vttLZDCyclin-dependent kinase 22.7.11.220.452
3rak03ZCyclin-dependent kinase 22.7.11.220.452
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.452
4j95ACPFibroblast growth factor receptor 2/0.451
1e9hINRCyclin-dependent kinase 22.7.11.220.450
3i60E86Mitogen-activated protein kinase 12.7.11.240.450
3s1h56ZCyclin-dependent kinase 22.7.11.220.450
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.450
3nynSGVG protein-coupled receptor kinase 62.7.11.160.449
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.449
4btjADPTau-tubulin kinase 12.7.11.10.449
4dgo0JWCasein kinase II subunit alpha2.7.11.10.449
4grb0XGCasein kinase II subunit alpha2.7.11.10.449
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.448
5av3KMPDeath-associated protein kinase 12.7.11.10.447
3lpbNVBTyrosine-protein kinase JAK2/0.446
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.446
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.445
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.445
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.444
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.444
4fv6E57Mitogen-activated protein kinase 12.7.11.240.444
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.443
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
3gubGUBDeath-associated protein kinase 12.7.11.10.442
3ortAGSSerine/threonine protein kinase/0.442