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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase/1.000
3r3sNADPutative oxidoreductase/0.518
4fn4NADShort chain dehydrogenase/0.515
3p19NDPPutative blue fluorescent protein/0.512
2wsbNADGalactitol dehydrogenase/0.509
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.509
5jydNADShort chain dehydrogenase/0.508
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.507
2jahNDPClavaldehyde dehydrogenase/0.507
2wdzNADGalactitol dehydrogenase/0.507
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.504
4bmvNAPShort-chain dehydrogenase/0.502
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.501
3lqfNADGalactitol dehydrogenase/0.500
3d3wNAPL-xylulose reductase1.1.1.100.497
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.496
4hwkNAPSepiapterin reductase1.1.1.1530.496
2dteNAIGlucose 1-dehydrogenase related protein/0.495
1xg5NAPDehydrogenase/reductase SDR family member 11/0.493
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.493
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.491
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.490
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.490
1xkqNDPUncharacterized protein/0.488
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.487
3w8eNAD3-hydroxybutyrate dehydrogenase/0.484
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.484
4gh5NADShort-chain dehydrogenase/reductase SDR/0.484
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.480
4yagNAIC alpha-dehydrogenase/0.480
4j7xNAPSepiapterin reductase1.1.1.1530.478
1yqdNAPSinapyl alcohol dehydrogenase/0.477
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.477
3uceNDPDehydrogenase/0.477
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.477
1uayADNOxidoreductase/0.476
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.476
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.476
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.475
3gegNADShort-chain dehydrogenase/reductase SDR/0.475
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.474
4yaiNAIC alpha-dehydrogenase/0.474
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.474
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.472
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.472
1ae1NAPTropinone reductase 1/0.471
2ylrNAPPhenylacetone monooxygenase1.14.13.920.470
3toxNAPPutative oxidoreductase/0.470
1snyNAPLD36273p/0.469
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.469
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.468
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
2z1mNDPGDP-mannose 4,6-dehydratase/0.467
3l77NJPShort-chain alcohol dehydrogenase/0.467
3sjuNDPKeto reductase/0.467
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.466
1iy8NADLevodione reductase/0.466
1pr9NAPL-xylulose reductase1.1.1.100.466
3wdsNADNADH-dependent quinuclidinone reductase/0.466
4j7uNAPSepiapterin reductase1.1.1.1530.466
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.466
1x7hNDPPutative ketoacyl reductase1.3.10.465
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.465
3jv7NADSecondary alcohol dehydrogenase/0.465
3wmxNADNAD dependent epimerase/dehydratase/0.465
1ipeNDPTropinone reductase 21.1.1.2360.464
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.464
4oaqNDPR-specific carbonyl reductase/0.464
1zemNADXylitol dehydrogenase/0.463
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.463
5jlaNADPutative short-chain dehydrogenase/reductase/0.463
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.461
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.460
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.460
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.460
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.459
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.458
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.458
4a84DXCMajor pollen allergen Bet v 1-A/0.458
4b79NADProbable short-chain dehydrogenase/0.458
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.457
5ig2NADShort-chain dehydrogenase/reductase SDR/0.457
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.456
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.456
4ap3FADSteroid monooxygenase/0.455
4dpwAGSMevalonate diphosphate decarboxylase/0.455
4q71FADBifunctional protein PutA/0.455
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.454
1geeNADGlucose 1-dehydrogenase1.1.1.470.454
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.453
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.453
1gcoNADGlucose 1-dehydrogenase1.1.1.470.452
3s55NADPutative short-chain dehydrogenase/reductase/0.452
3tjzGNPADP-ribosylation factor 1/0.452
3w8fNAD3-hydroxybutyrate dehydrogenase/0.452
1b14NADAlcohol dehydrogenase1.1.1.10.451
1sbyNADAlcohol dehydrogenase1.1.1.10.451
1wntNAPL-xylulose reductase1.1.1.100.451
5idwNAPShort-chain dehydrogenase/reductase SDR/0.451
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.450
1oaaNAPSepiapterin reductase1.1.1.1530.450
3tn7NJPShort-chain alcohol dehydrogenase/0.450
2yy7NADL-threonine dehydrogenase/0.449
3vdqNAD3-hydroxybutyrate dehydrogenase/0.449
1w4zNAPPutative ketoacyl reductase1.3.10.448
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.448
2p5uNADUDP-glucose 4-epimerase/0.448
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
3f3sNADLambda-crystallin homolog/0.448
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.448
3pefNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.447
3qrwNDPPutative ketoacyl reductase1.3.10.447
1h2bNAJNAD-dependent alcohol dehydrogenase/0.446
1n5dNDPCarbonyl reductase [NADPH] 1/0.446
1nytNAPShikimate dehydrogenase (NADP(+))/0.446
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.446
3tvuB37Acetyl-CoA carboxylase/0.446
4dc1NDPPutative ketoacyl reductase1.3.10.446
1x7gNAPPutative ketoacyl reductase1.3.10.445
3rj9NADAlcohol dehydrogenase1.1.1.10.445
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.444
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.444
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.444
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.443
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.443
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.443
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.442
4c4oNADSADH/0.442
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.442
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.441
1qorNDPQuinone oxidoreductase 1/0.440
2fznFADBifunctional protein PutA1.5.5.20.440
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3ak4NADNADH-dependent quinuclidinone reductase/0.440
3s5wFADL-ornithine N(5)-monooxygenase/0.440
4eu5COASuccinyl-CoA:acetate CoA-transferase/0.440