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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cpb NAD Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.159
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.952
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.933
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.931
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.927
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.926
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.916
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.907
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.897
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.892
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.890
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.889
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.880
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.878
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.867
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.856
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.855
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.851
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.849
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.843
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.828
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.817
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.815
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.806
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.801
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.800
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.797
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.792
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.792
3ak4 NADNADH-dependent quinuclidinone reductase / 0.788
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.785
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.780
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.780
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.769
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.769
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.768
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.767
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.764
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.764
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.764
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.762
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.761
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.760
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.758
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.758
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.756
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.756
1x7g NAPPutative ketoacyl reductase 1.3.1 0.752
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.750
3wds NADNADH-dependent quinuclidinone reductase / 0.750
4hxy NDPPlm1 / 0.748
4b79 NADProbable short-chain dehydrogenase / 0.747
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.745
2jah NDPClavaldehyde dehydrogenase / 0.742
3s55 NADPutative short-chain dehydrogenase/reductase / 0.742
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.741
2p5y NADUDP-glucose 4-epimerase / 0.740
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.739
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.738
3sx2 NADUncharacterized protein / 0.737
5jyd NADShort chain dehydrogenase / 0.736
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.735
1sny NAPLD36273p / 0.734
2wsb NADGalactitol dehydrogenase / 0.734
5d2e NAPMlnE / 0.734
2yut NAPPutative short-chain oxidoreductase / 0.733
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.733
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.733
3r3s NADPutative oxidoreductase / 0.732
3sju NDPKeto reductase / 0.732
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.731
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.731
4j7u NAPSepiapterin reductase 1.1.1.153 0.729
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.729
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.728
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.728
2c29 NAPDihydroflavonol 4-reductase / 0.727
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.727
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.725
3bmo NAPPteridine reductase / 0.724
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.723
2wdz NADGalactitol dehydrogenase / 0.723
4j7x NAPSepiapterin reductase 1.1.1.153 0.723
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.722
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.721
3ai2 NDPNADPH-sorbose reductase / 0.718
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.718
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.718
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.717
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.717
4yag NAIC alpha-dehydrogenase / 0.717
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.716
2b36 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.716
1zem NADXylitol dehydrogenase / 0.715
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.714
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.714
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.712
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.710
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.710
1pr9 NAPL-xylulose reductase 1.1.1.10 0.709
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.708
3tsc NADUncharacterized protein / 0.707
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.706
3ai3 NDPNADPH-sorbose reductase / 0.706
4clo NAPPteridine reductase / 0.706
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.706
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.705
1zid ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.704
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.704
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.702
4wec NADShort chain dehydrogenase / 0.702
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.701
3o26 NDPSalutaridine reductase / 0.701
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.698
3h4v NAPPteridine reductase 1 1.5.1.33 0.698
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.697
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.696
1bvr NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.695
5jla NADPutative short-chain dehydrogenase/reductase / 0.695
3geg NADShort-chain dehydrogenase/reductase SDR / 0.694
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.694
4qec NAPElxO / 0.694
3aw9 NADNAD-dependent epimerase/dehydratase / 0.693
1ae1 NAPTropinone reductase 1 / 0.692
4qed NAPElxO / 0.692
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.691
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.690
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.690
4n5n NAPAcetoacetyl-CoA reductase 1.1.1.36 0.690
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.688
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.688
5lc1 NADL-threonine 3-dehydrogenase / 0.687
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.686
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.686
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.685
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.684
3orf NADDihydropteridine reductase 1.5.1.34 0.684
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.683
3d3w NAPL-xylulose reductase 1.1.1.10 0.683
4hbg NDP3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.683
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.682
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.682
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.681
1ipe NDPTropinone reductase 2 1.1.1.236 0.681
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.681
5b1y NDP3-oxoacyl-[acyl-carrier-protein] reductase / 0.681
2yy7 NADL-threonine dehydrogenase / 0.680
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.680
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.680
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.679
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.679
2z1m NDPGDP-mannose 4,6-dehydratase / 0.679
2bd0 NAPSepiapterin reductase / 0.678
2dte NAIGlucose 1-dehydrogenase related protein / 0.678
1u7t NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.677
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.677
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.675
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.675
1sby NADAlcohol dehydrogenase 1.1.1.1 0.674
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.674
3f1k NAPUncharacterized oxidoreductase YciK 1 0.673
3l77 NJPShort-chain alcohol dehydrogenase / 0.673
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.672
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.671
3tn7 NJPShort-chain alcohol dehydrogenase / 0.669
4yai NAIC alpha-dehydrogenase / 0.669
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.668
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.668
2nq8 ZIDEnoyl-ACP reductase / 0.666
2bfo NDPPteridine reductase 1 1.5.1.33 0.664
1v35 NAIEnoyl-ACP reductase / 0.663
4dbz NDPPutative ketoacyl reductase 1.3.1 0.662
3a9w NADNDP-sugar epimerase / 0.661
4kwh NAPReductase homolog / 0.660
1t2a NDPGDP-mannose 4,6 dehydratase 4.2.1.47 0.658
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.658
4u7w NDPMxaA / 0.658
1w4z NAPPutative ketoacyl reductase 1.3.1 0.657
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.657
4twr NADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase / 0.657
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.656
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.656
1vrw NAIEnoyl-ACP reductase / 0.654
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.654
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.653
3ajr NADNDP-sugar epimerase / 0.653
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.653
1orr NADCDP-paratose 2-epimerase / 0.652
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.652
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.652
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.650