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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5a1t NAI L-lactate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5a1t NAIL-lactate dehydrogenase / 1.097
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.873
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.859
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.848
1pzh NADLactate dehydrogenase / 0.839
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.835
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.830
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.824
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.816
1bdm NAXMalate dehydrogenase / 0.797
2a92 NAIL-lactate dehydrogenase / 0.794
1sow NADL-lactate dehydrogenase 1.1.1.27 0.788
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.778
4ros APRMalate dehydrogenase / 0.775
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.767
1bmd NADMalate dehydrogenase / 0.766
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.765
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.759
1u7h NADPutative ornithine cyclodeaminase / 0.758
1b8v NADMalate dehydrogenase / 0.757
2x0i NAIMalate dehydrogenase / 0.756
1o6z NADMalate dehydrogenase / 0.755
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.751
1pzf A3DLactate dehydrogenase / 0.746
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.744
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.741
1wze NADMalate dehydrogenase / 0.738
4i1i NADMalate dehydrogenase / 0.735
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.734
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.731
4oaq NDPR-specific carbonyl reductase / 0.730
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.727
1ie3 NADMalate dehydrogenase / 0.726
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.724
1yqx NAPSinapyl alcohol dehydrogenase / 0.722
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.721
1b8u NADMalate dehydrogenase / 0.720
3two NDPMannitol dehydrogenase / 0.720
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.718
1yqd NAPSinapyl alcohol dehydrogenase / 0.717
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.716
4j43 NADUncharacterized protein / 0.716
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.716
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.715
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.715
1ib6 NADMalate dehydrogenase / 0.714
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.712
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.708
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.707
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.706
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.705
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.705
1y7t NDPMalate dehydrogenase / 0.704
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.704
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.703
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.702
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.700
1gv0 NADMalate dehydrogenase / 0.699
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.699
1u8x NADMaltose-6'-phosphate glucosidase 3.2.1.122 0.698
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.697
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.697
1wvg APRCDP-glucose 4,6-dehydratase 4.2.1.45 0.694
2nad NADFormate dehydrogenase / 0.694
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.691
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.691
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.689
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.689
3gvh NADMalate dehydrogenase / 0.687
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.687
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.687
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.686
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.685
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.685
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.684
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.684
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.684
1emd NADMalate dehydrogenase / 0.683
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.683
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.683
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.682
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.682
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.681
2voj NADAlanine dehydrogenase 1.4.1.1 0.681
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.679
2o4c NADErythronate-4-phosphate dehydrogenase / 0.678
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.677
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.676
2xaa NADSecondary alcohol dehydrogenase / 0.675
3icp NADNAD-dependent epimerase/dehydratase / 0.675
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.674
4b4o NDPEpimerase family protein SDR39U1 / 0.674
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.674
1wzi NDPMalate dehydrogenase / 0.673
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.673
4lcj NADC-terminal-binding protein 2 / 0.673
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.673
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.673
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.672
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.671
3wle NAD(R)-specific carbonyl reductase / 0.671
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.671
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.671
1i3l NADUDP-glucose 4-epimerase / 0.670
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.670
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.669
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.669
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.667
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.667
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.667
3kb6 NADD-lactate dehydrogenase / 0.667
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.666
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.666
4j4b NAIUncharacterized protein / 0.666
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.665
4j49 NAIUncharacterized protein / 0.665
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.664
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.663
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.663
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.663
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.663
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.663
3ec7 NADInositol 2-dehydrogenase / 0.662
1uxk NADMalate dehydrogenase / 0.661
1x7d NADPutative ornithine cyclodeaminase / 0.660
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.660
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.660
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.659
3nt2 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.658
4y1b NAPAntE / 0.658
4uun NAIL-lactate dehydrogenase / 0.657
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.656
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.656
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.656
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.655
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.655
3keo NADRedox-sensing transcriptional repressor Rex / 0.655
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.654
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.654
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.654
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.653
4xqc NADHomospermidine synthase 2.5.1.44 0.653
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.652
1pjc NADAlanine dehydrogenase / 0.652
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.652
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.651
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.651
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.650
2cvq NDPMalate dehydrogenase / 0.650
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.650