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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4y12 AGS Serine/threonine-protein kinase PknG 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 1.023
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.907
2pui ADPMethylthioribose kinase 2.7.1.100 0.768
2pup ADPMethylthioribose kinase 2.7.1.100 0.741
2pyw ADPMethylthioribose kinase 2.7.1.100 0.736
2pul ACPMethylthioribose kinase 2.7.1.100 0.731
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.729
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.719
2olc ADPMethylthioribose kinase 2.7.1.100 0.716
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.716
2pun ACPMethylthioribose kinase 2.7.1.100 0.714
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.711
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
4dee ADPAurora kinase A 2.7.11.1 0.703
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.701
1ol6 ATPAurora kinase A 2.7.11.1 0.701
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.698
5eg3 ACPFibroblast growth factor receptor 2 / 0.698
4ceg ADPAurora kinase A 2.7.11.1 0.696
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.696
5iqa GNPBifunctional AAC/APH 2.3.1 0.694
3c50 ADPRhodopsin kinase / 0.693
3c4z ADPRhodopsin kinase / 0.692
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.690
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.690
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.690
1pjk ANPCasein kinase II subunit alpha 2.7.11.1 0.689
3t8o ATPRhodopsin kinase / 0.689
4ork GDPBifunctional AAC/APH 2.3.1 0.689
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.686
4gyi ADPUncharacterized protein / 0.685
4bn1 ADPAurora kinase A 2.7.11.1 0.684
4utd ACPAurora kinase A 2.7.11.1 0.684
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.683
3bu5 ATPInsulin receptor 2.7.10.1 0.683
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.683
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.682
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.682
5drd ATPAurora kinase A 2.7.11.1 0.682
1mq4 ADPAurora kinase A 2.7.11.1 0.681
2dwb ANPAurora kinase A 2.7.11.1 0.681
3c4w ATPRhodopsin kinase / 0.681
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.679
3qc9 ADPRhodopsin kinase / 0.678
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.677
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.677
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.676
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.676
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.676
4o1p ANPRibonuclease L / 0.676
4qny ANPMitogen activated protein kinase, putative / 0.676
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.673
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.673
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.673
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.672
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.672
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.670
3q5i ANPProtein kinase, putative / 0.670
4xlv ACPInsulin receptor 2.7.10.1 0.670
5dt3 ATPAurora kinase A 2.7.11.1 0.669
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.668
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.668
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.667
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.667
5iqd GNPBifunctional AAC/APH 2.3.1 0.667
3oro AGSSerine/threonine protein kinase / 0.666
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.665
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.665
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.664
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.664
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.664
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.663
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.662
2pzp ACPFibroblast growth factor receptor 2 / 0.661
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.661
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.661
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.661
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.660
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.660
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.657
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.657
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.656
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.656
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2p0a ANPSynapsin-3 / 0.655
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.655
1pk8 ATPSynapsin-1 / 0.654
3c4x ATPRhodopsin kinase / 0.654
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.654
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.653
4mv8 ACPBiotin carboxylase 6.3.4.14 0.653
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.652
3rv4 ADPBiotin carboxylase 6.3.4.14 0.652
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.652
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.652
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.651
5iqe GNPBifunctional AAC/APH 2.3.1 0.651
1u54 ACPActivated CDC42 kinase 1 / 0.650
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.650
4p5a FADFlavin-dependent thymidylate synthase / 0.650
4q5h ANPProtein kinase OspG 2.7 0.650