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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4utd ACP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4utd ACPAurora kinase A 2.7.11.1 0.986
4dee ADPAurora kinase A 2.7.11.1 0.899
1mq4 ADPAurora kinase A 2.7.11.1 0.869
5dn3 ATPAurora kinase A 2.7.11.1 0.858
5dt3 ATPAurora kinase A 2.7.11.1 0.856
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.847
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.830
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.821
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.820
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.820
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.818
4ceg ADPAurora kinase A 2.7.11.1 0.812
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.811
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.807
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.807
1ol5 ADPAurora kinase A 2.7.11.1 0.804
4bn1 ADPAurora kinase A 2.7.11.1 0.801
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.801
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.798
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.793
2dwb ANPAurora kinase A 2.7.11.1 0.792
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.790
2pup ADPMethylthioribose kinase 2.7.1.100 0.788
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.787
5dr2 ATPAurora kinase A 2.7.11.1 0.787
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.785
5dt4 ATPAurora kinase A 2.7.11.1 0.785
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.782
2pui ADPMethylthioribose kinase 2.7.1.100 0.781
5dnr ATPAurora kinase A 2.7.11.1 0.779
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.776
4ysj ADPCalmodulin-like domain protein kinase / 0.776
5drd ATPAurora kinase A 2.7.11.1 0.774
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.773
3c50 ADPRhodopsin kinase / 0.773
3cly ACPFibroblast growth factor receptor 2 / 0.773
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.771
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.765
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.765
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.763
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.762
2pyw ADPMethylthioribose kinase 2.7.1.100 0.762
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.762
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.761
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.757
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.756
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.755
4xlv ACPInsulin receptor 2.7.10.1 0.754
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.751
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.751
4gyi ADPUncharacterized protein / 0.751
2olc ADPMethylthioribose kinase 2.7.1.100 0.750
3bu5 ATPInsulin receptor 2.7.10.1 0.750
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.750
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.750
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.750
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.748
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.746
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
3c4z ADPRhodopsin kinase / 0.741
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.741
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.740
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.735
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.735
1ol6 ATPAurora kinase A 2.7.11.1 0.734
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.734
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.734
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.733
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.733
5ce3 ADPProtein kinase YopO / 0.733
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.732
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.732
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.730
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.730
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.730
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.726
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.726
4qny ANPMitogen activated protein kinase, putative / 0.726
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.725
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.723
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.723
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
5dos ATPAurora kinase A 2.7.11.1 0.723
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.722
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.720
3ori AGSSerine/threonine protein kinase / 0.720
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.720
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.719
4ork GDPBifunctional AAC/APH 2.3.1 0.718
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.717
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.715
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.710
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
3t8o ATPRhodopsin kinase / 0.710
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.710
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.709
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.708
2pz5 ACPFibroblast growth factor receptor 2 / 0.708
5iqh GNPBifunctional AAC/APH 2.3.1 0.707
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.704
5iqi GNPBifunctional AAC/APH 2.3.1 0.704
5iqb GNPBifunctional AAC/APH 2.3.1 0.703
3nie ANPMitogen-activated protein kinase / 0.700
1ol7 ADPAurora kinase A 2.7.11.1 0.699
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.699
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.698
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.698
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.698
3oro AGSSerine/threonine protein kinase / 0.698
3qc9 ADPRhodopsin kinase / 0.698
4n57 ADPAPH(2'')-Id / 0.698
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.696
5l8j ADPAurora kinase A 2.7.11.1 0.696
2vqd AP2Biotin carboxylase 6.3.4.14 0.695
2pzp ACPFibroblast growth factor receptor 2 / 0.694
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.694
4o0u ADNAurora kinase A 2.7.11.1 0.694
1m0w ANPGlutathione synthetase 6.3.2.3 0.693
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.693
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.690
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.690
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.690
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.690
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.689
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.688
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.687
2pun ACPMethylthioribose kinase 2.7.1.100 0.686
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.686
3q5i ANPProtein kinase, putative / 0.686
4ix5 ANPUncharacterized protein / 0.685
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.685
5iqa GNPBifunctional AAC/APH 2.3.1 0.685
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.684
2py3 ACPFibroblast growth factor receptor 2 / 0.683
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.683
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.682
4fu0 ADPD-alanine--D-alanine ligase / 0.682
5eg3 ACPFibroblast growth factor receptor 2 / 0.682
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.681
2pul ACPMethylthioribose kinase 2.7.1.100 0.681
5iqe GNPBifunctional AAC/APH 2.3.1 0.681
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.680
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.679
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.679
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.678
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.678
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.678
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.678
4o0w ADNAurora kinase A 2.7.11.1 0.678
5iqd GNPBifunctional AAC/APH 2.3.1 0.677
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.676
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.676
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.675
1cm8 ANPMitogen-activated protein kinase 12 / 0.674
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.674
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.674
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.673
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.672
3tdw GDPGentamicin resistance protein / 0.672
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.672
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.672
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.671
4ffm ADPUncharacterized protein / 0.671
2wqe ADPAurora kinase A 2.7.11.1 0.670
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.670
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.670
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.668
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
2j9g ADPBiotin carboxylase 6.3.4.14 0.666
2vgo AD5Aurora kinase B-A 2.7.11.1 0.666
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.666
4ffl ADPUncharacterized protein / 0.666
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.666
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.665
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3c4w ATPRhodopsin kinase / 0.663
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.663
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.663
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.663
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.662
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.662
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.662
2ym6 YM6Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.661
5l8l ADPAurora kinase A 2.7.11.1 0.661
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.660
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
1rfu ADPPyridoxal kinase 2.7.1.35 0.659
2dwp ACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.659
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.659
4cvl ACPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.659
1i44 ACPInsulin receptor 2.7.10.1 0.657
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
3vx4 ATPPutative ABC transporter, ATP-binding protein ComA / 0.657
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.656
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.656
4ffr ATPUncharacterized protein / 0.656
4lfg IPEPutative geranyltranstransferase / 0.656
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.656
5byl GCPBifunctional AAC/APH 2.3.1 0.656
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2pml ANPUncharacterized protein / 0.654
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.654
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.654
5iqg GDPBifunctional AAC/APH 2.3.1 0.654
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.653
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.652
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3zo4 QWIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.651
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.651
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.650