Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nzo ANP Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 1.127
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 1.089
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 1.068
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.993
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.972
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.957
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.948
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.852
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.839
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.829
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.798
2p0a ANPSynapsin-3 / 0.796
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.793
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.790
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.790
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.780
3rv4 ADPBiotin carboxylase 6.3.4.14 0.777
3wnz ADPAlanine--anticapsin ligase / 0.777
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.772
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.762
3tw6 ADPPyruvate carboxylase / 0.756
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.755
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
5c1o ANPD-alanine--D-alanine ligase / 0.752
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.749
4ffl ADPUncharacterized protein / 0.747
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.744
3g8d ADPBiotin carboxylase 6.3.4.14 0.739
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.739
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.737
1m0w ANPGlutathione synthetase 6.3.2.3 0.735
1px2 ATPSynapsin-1 / 0.735
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.733
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.733
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.732
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
4ffr ATPUncharacterized protein / 0.730
3wo0 ADPAlanine--anticapsin ligase / 0.729
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.728
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.727
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.727
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.722
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.722
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
5c1p ADPD-alanine--D-alanine ligase / 0.721
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.718
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.714
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.713
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.713
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.709
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.707
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.705
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.703
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.701
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.701
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
2hgs ADPGlutathione synthetase 6.3.2.3 0.700
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.700
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.699
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.698
3r5f ATPD-alanine--D-alanine ligase / 0.697
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.696
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.694
3ufx GDPSuccinate--CoA ligase [GDP-forming] subunit beta / 0.693
4fu0 ADPD-alanine--D-alanine ligase / 0.693
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.692
2zdg ADPD-alanine--D-alanine ligase / 0.692
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.691
1pk8 ATPSynapsin-1 / 0.691
1aux AGSSynapsin-1 / 0.688
3pdt ADPMyosin heavy chain kinase A 2.7.11.7 0.687
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.686
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.685
3bu5 ATPInsulin receptor 2.7.10.1 0.683
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.683
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.682
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4zme ADNMyosin heavy chain kinase A 2.7.11.7 0.680
4dee ADPAurora kinase A 2.7.11.1 0.679
5bpf ADPD-alanine--D-alanine ligase / 0.677
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.677
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.675
4mv8 ACPBiotin carboxylase 6.3.4.14 0.675
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.675
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
5jqw ADPN5-carboxyaminoimidazole ribonucleotide synthase / 0.674
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.673
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4mv3 ACPBiotin carboxylase 6.3.4.14 0.673
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.672
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.672
4utd ACPAurora kinase A 2.7.11.1 0.672
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.666
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.665
4o4i ACPTubulin tyrosine ligase / 0.665
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.664
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.664
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.664
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.664
3c50 ADPRhodopsin kinase / 0.664
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.664
4ffm ADPUncharacterized protein / 0.664
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.662
3wo1 ADPAlanine--anticapsin ligase / 0.662
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.662
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.661
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.658
4mv1 ADPBiotin carboxylase 6.3.4.14 0.658
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.656
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.656
3qc9 ADPRhodopsin kinase / 0.656
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
5iqf GDPBifunctional AAC/APH 2.3.1 0.656
2pyw ADPMethylthioribose kinase 2.7.1.100 0.655
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.655
2r86 ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.654
4jl8 ADPAdenylate kinase / 0.653
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.653
1dv2 ATPBiotin carboxylase 6.3.4.14 0.652
3a5y KAAElongation factor P--(R)-beta-lysine ligase / 0.651
5iqe GNPBifunctional AAC/APH 2.3.1 0.651
1ol5 ADPAurora kinase A 2.7.11.1 0.650
2vqd AP2Biotin carboxylase 6.3.4.14 0.650
4gyi ADPUncharacterized protein / 0.650