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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jqe ANP Casein kinase II subunit alpha 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.994
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.874
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.787
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.761
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.755
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.746
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.740
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.739
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.738
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.730
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.723
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.719
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.719
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.716
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.714
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.711
4qny ANPMitogen activated protein kinase, putative / 0.711
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.709
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.705
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.704
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.701
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.700
3ort AGSSerine/threonine protein kinase / 0.700
5ce3 ADPProtein kinase YopO / 0.697
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.696
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.694
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.694
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.694
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.694
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.693
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.693
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.692
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.692
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.691
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.691
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.690
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.689
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.688
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.687
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.686
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.685
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.685
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.685
4utd ACPAurora kinase A 2.7.11.1 0.685
5drd ATPAurora kinase A 2.7.11.1 0.685
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.684
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
1u54 ACPActivated CDC42 kinase 1 / 0.683
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.683
3t8o ATPRhodopsin kinase / 0.682
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.682
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.681
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.681
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.680
2pun ACPMethylthioribose kinase 2.7.1.100 0.680
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.680
2zdg ADPD-alanine--D-alanine ligase / 0.680
3oro AGSSerine/threonine protein kinase / 0.680
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.679
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.678
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.677
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.677
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.677
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.677
5dt3 ATPAurora kinase A 2.7.11.1 0.676
4c3r ACPAurora kinase A 2.7.11.1 0.675
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.674
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.674
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.673
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.673
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.673
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.673
5dr2 ATPAurora kinase A 2.7.11.1 0.673
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.672
3orp AGSSerine/threonine protein kinase / 0.671
5eg3 ACPFibroblast growth factor receptor 2 / 0.671
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.670
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.669
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.669
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.668
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.668
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.668
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.667
1ol6 ATPAurora kinase A 2.7.11.1 0.666
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.666
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.666
5dn3 ATPAurora kinase A 2.7.11.1 0.666
2dwb ANPAurora kinase A 2.7.11.1 0.665
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.665
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.664
4lv8 ADPRhoptry protein 5 C / 0.664
1m0w ANPGlutathione synthetase 6.3.2.3 0.662
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.662
2wqe ADPAurora kinase A 2.7.11.1 0.662
3ork AGSSerine/threonine protein kinase / 0.662
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.662
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.662
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.662
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.660
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.660
4fg9 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.660
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.659
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.659
3q5i ANPProtein kinase, putative / 0.659
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.658
2pup ADPMethylthioribose kinase 2.7.1.100 0.658
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.658
3a8w ATPProtein kinase C iota type 2.7.11.13 0.658
3ori AGSSerine/threonine protein kinase / 0.658
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.657
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.656
3pzc GAPAmino acid--[acyl-carrier-protein] ligase 1 6.2.1.n2 0.656
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.655
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.655
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.655
5dos ATPAurora kinase A 2.7.11.1 0.655
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.654
3llt ANPProtein serine/threonine kinase-1 / 0.654
2olc ADPMethylthioribose kinase 2.7.1.100 0.653
2ql6 ADPNicotinamide riboside kinase 1 / 0.653
4iwx ADPRibosomal protein S6--L-glutamate ligase / 0.653
4o1p ANPRibonuclease L / 0.653
5dnr ATPAurora kinase A 2.7.11.1 0.652
5l8l ADPAurora kinase A 2.7.11.1 0.652
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.650
3orm AGSSerine/threonine protein kinase / 0.650
4n57 ADPAPH(2'')-Id / 0.650