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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ji9 1M3 Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ji9 1M3Tyrosine-protein kinase JAK2 / 1.022
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.769
3uo5 0BXAurora kinase A 2.7.11.1 0.757
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.754
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.742
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.740
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.729
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.728
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.726
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.725
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.721
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.710
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.708
1oec AA2Fibroblast growth factor receptor 2 / 0.701
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.699
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.699
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.696
4jia 1K3Tyrosine-protein kinase JAK2 / 0.694
4j53 1J4Serine/threonine-protein kinase PLK1 2.7.11.21 0.687
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.681
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.681
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.679
3cqu CQURAC-alpha serine/threonine-protein kinase 2.7.11.1 0.669
3i4b Z48Glycogen synthase kinase-3 beta 2.7.11.26 0.665
5dr6 SKEAurora kinase A 2.7.11.1 0.663
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.662
4im0 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
2rku R78Serine/threonine-protein kinase PLK1 2.7.11.21 0.659
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.658
4j52 1J3Serine/threonine-protein kinase PLK1 2.7.11.21 0.658
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
4gii 0X6Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.657
4c61 LMMTyrosine-protein kinase JAK2 / 0.654
3eyh IZATyrosine-protein kinase JAK1 / 0.652
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.650
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.650