Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jdc NAD Probable pyrroline-5-carboxylate dehydrogenase RocA

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.885
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.818
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.766
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.762
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.756
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.755
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.742
4i9b NADPutative betaine aldehyde dehyrogenase / 0.741
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.739
4i3v NADAldehyde dehydrogenase (NAD+) / 0.738
3b4w NADAldehyde dehydrogenase family protein / 0.736
3iwj NADAminoaldehyde dehydrogenase / 0.735
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.735
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.732
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.731
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.729
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.727
4i8p NADAminoaldehyde dehydrogenase 1 / 0.725
4i8q NADPutative betaine aldehyde dehyrogenase / 0.724
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.719
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.717
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.717
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.716
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.716
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.716
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.714
1bi9 NADRetinal dehydrogenase 2 / 0.711
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.710
4i3w NADAldehyde dehydrogenase (NAD+) / 0.709
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.708
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.707
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.706
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.706
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.702
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.701
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.700
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.699
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.698
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.698
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.697
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.695
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.694
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.693
2jg7 NADAntiquitin / 0.691
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.688
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.688
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.686
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.685
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.682
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.680
4h73 NDPAldehyde dehydrogenase / 0.678
4c3s NADAldehyde Dehydrogenase / 0.675
4nmj NAPAldehyde dehydrogenase / 0.674
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.665
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.656
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.656
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.652
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.651
3haz NADBifunctional protein PutA / 0.651