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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ihi NAD Probable pyrroline-5-carboxylate dehydrogenase RocA

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 1.210
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.874
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.874
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.865
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.865
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.855
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.852
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.849
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.836
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.835
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.818
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.811
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.808
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.804
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.802
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.800
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.800
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.799
4i8q NADPutative betaine aldehyde dehyrogenase / 0.799
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.798
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.795
3haz NADBifunctional protein PutA / 0.791
4i8p NADAminoaldehyde dehydrogenase 1 / 0.786
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.781
4pz2 NADAldehyde dehydrogenase 2-6 / 0.778
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.775
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.772
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.770
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.766
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.764
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.762
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.761
3b4w NADAldehyde dehydrogenase family protein / 0.751
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.750
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.750
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.747
2jg7 NADAntiquitin / 0.744
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.742
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.742
4i3v NADAldehyde dehydrogenase (NAD+) / 0.742
4i3w NADAldehyde dehydrogenase (NAD+) / 0.740
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.739
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.739
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.738
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.737
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.737
4pxl NADAldehyde dehydrogenase3 / 0.735
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.731
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.730
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.725
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.723
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.717
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.717
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.715
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.714
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.713
4f3x NADPutative aldehyde dehydrogenase / 0.713
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.710
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.709
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.702
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.701
4nmj NAPAldehyde dehydrogenase / 0.697
4pt0 NADAldehyde dehydrogenase / 0.697
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.693
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.693
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.692
1bi9 NADRetinal dehydrogenase 2 / 0.691
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.690
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.689
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.689
4c3s NADAldehyde Dehydrogenase / 0.683
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.680
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.679
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.676
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.671
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.671
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.669
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.667
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.667
4h73 NDPAldehyde dehydrogenase / 0.667
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.666
4nmk NAPAldehyde dehydrogenase / 0.664
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.663
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.657
5eyu NADBetaine-aldehyde dehydrogenase / 0.657
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.651