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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c2w ANP Aurora kinase B-A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c2w ANPAurora kinase B-A 2.7.11.1 0.792
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.691
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.677
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.673
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.670
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.667
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.666
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.665
4ft9 H4KSerine/threonine-protein kinase Chk1 2.7.11.1 0.664
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.662
4j97 ACPFibroblast growth factor receptor 2 / 0.662
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.659
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.658
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.657
4xhg ADPUncharacterized protein / 0.657
4b8l A0PAurora kinase B-A 2.7.11.1 0.656
4ix6 ADPUncharacterized protein / 0.654
2x9n AX3Pteridine reductase / 0.653
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.653
5ani ES4Cyclin-dependent kinase 2 2.7.11.22 0.653
4dt8 ADNAPH(2'')-Id / 0.652
4ez3 0S0Cyclin-dependent kinase 2 2.7.11.22 0.652
3x03 ANPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta 2.7.1.149 0.651
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.651
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.650
3juh ANPCasein kinase II subunit alpha 2.7.11.1 0.650
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.650
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.650
4fta H5KSerine/threonine-protein kinase Chk1 2.7.11.1 0.650