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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bu9 08C Tankyrase-2 2.4.2.30

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bu9 08CTankyrase-2 2.4.2.30 0.969
4bus 32FTankyrase-2 2.4.2.30 0.945
4bud 29FTankyrase-2 2.4.2.30 0.921
4buv 16ITankyrase-2 2.4.2.30 0.913
4kzu A73Tankyrase-2 2.4.2.30 0.901
4but 31FTankyrase-2 2.4.2.30 0.898
4bux F35Tankyrase-2 2.4.2.30 0.891
3kr8 XAVTankyrase-2 2.4.2.30 0.885
5aku 29FTankyrase-2 2.4.2.30 0.873
4bue JQFTankyrase-2 2.4.2.30 0.872
4l0v 1V1Tankyrase-2 2.4.2.30 0.867
4kzl 20DTankyrase-2 2.4.2.30 0.865
4buu F38Tankyrase-2 2.4.2.30 0.861
4l0s 1UZTankyrase-2 2.4.2.30 0.860
4l10 A63Tankyrase-2 2.4.2.30 0.857
4buf F36Tankyrase-2 2.4.2.30 0.856
4l34 1VGTankyrase-2 2.4.2.30 0.854
4hlh 20DTankyrase-2 2.4.2.30 0.852
4bs4 A64Tankyrase-2 2.4.2.30 0.849
4buw F33Tankyrase-2 2.4.2.30 0.847
4hki FLNTankyrase-2 2.4.2.30 0.843
4hlm 16STankyrase-2 2.4.2.30 0.842
4l0t 1V0Tankyrase-2 2.4.2.30 0.842
4l09 1URTankyrase-2 2.4.2.30 0.838
4l33 F70Tankyrase-2 2.4.2.30 0.837
4hlf 15ZTankyrase-2 2.4.2.30 0.835
4hlk 431Tankyrase-2 2.4.2.30 0.833
4bui W2ETankyrase-2 2.4.2.30 0.830
4hlg 20BTankyrase-2 2.4.2.30 0.820
4hkk AGITankyrase-2 2.4.2.30 0.815
4l0i 1UWTankyrase-2 2.4.2.30 0.814
4avw G18Tankyrase-2 2.4.2.30 0.806
4l2k 1V8Tankyrase-2 2.4.2.30 0.801
4l31 F08Tankyrase-2 2.4.2.30 0.795
4l32 1VFTankyrase-2 2.4.2.30 0.786
4l2g 1V4Tankyrase-2 2.4.2.30 0.781
4l2f 1V3Tankyrase-2 2.4.2.30 0.778
4hkn LU2Tankyrase-2 2.4.2.30 0.774
4hl5 15WTankyrase-2 2.4.2.30 0.769
4hmh F94Tankyrase-2 2.4.2.30 0.767
4avu LDRTankyrase-2 2.4.2.30 0.765
4msg 2C6Tankyrase-1 2.4.2.30 0.754
4gv2 5MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.745
4bjb P34Tankyrase-2 2.4.2.30 0.739
4gv0 8MEPoly [ADP-ribose] polymerase 3 2.4.2.30 0.734
4mt9 2D6Tankyrase-1 2.4.2.30 0.732
3p0p NNFTankyrase-2 2.4.2.30 0.731
4bjc RPBTankyrase-2 2.4.2.30 0.731
3u9y 09LTankyrase-2 2.4.2.30 0.727
4li6 1XOTankyrase-1 2.4.2.30 0.715
4pnm NU1Tankyrase-2 2.4.2.30 0.715
4tjy 3GNTankyrase-2 2.4.2.30 0.713
3c49 KU8Poly [ADP-ribose] polymerase 3 2.4.2.30 0.709
4r5w XAVPoly [ADP-ribose] polymerase 1 2.4.2.30 0.706
4msk 2C8Tankyrase-1 2.4.2.30 0.704
4pnr G18Tankyrase-2 2.4.2.30 0.704
4gv4 MEJPoly [ADP-ribose] polymerase 3 2.4.2.30 0.700
4i9i 1DYTankyrase-1 2.4.2.30 0.695
3gn7 3GNPoly [ADP-ribose] polymerase 1 2.4.2.30 0.688
3l3m A92Poly [ADP-ribose] polymerase 1 2.4.2.30 0.684
2rd6 78PPoly [ADP-ribose] polymerase 1 2.4.2.30 0.682
2rcw AAIPoly [ADP-ribose] polymerase 1 2.4.2.30 0.681
4j3m AJ8Tankyrase-2 2.4.2.30 0.681
4gv7 MEWPoly [ADP-ribose] polymerase 1 2.4.2.30 0.673
5ds3 09LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.671
5dsy UHBPoly [ADP-ribose] polymerase 2 2.4.2.30 0.670
5ewk P34Putative secreted protein / 0.670
4bj9 UHBTankyrase-2 2.4.2.30 0.668
1efy BZCPoly [ADP-ribose] polymerase 1 2.4.2.30 0.666
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4krs 1SXTankyrase-1 2.4.2.30 0.655
4tvj 09LPoly [ADP-ribose] polymerase 2 2.4.2.30 0.655
3l3l L3LPoly [ADP-ribose] polymerase 1 2.4.2.30 0.652
4f1l 0RYPoly [ADP-ribose] polymerase 14 2.4.2.30 0.652
4j21 AJ6Tankyrase-2 2.4.2.30 0.651