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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3up5 FAD 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.431
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.219
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.191
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.178
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.141
3gwd FADCyclohexanone monooxygenase / 1.072
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.030
4d04 FADPhenylacetone monooxygenase 1.14.13.92 1.002
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.945
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.924
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.922
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.888
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.869
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.849
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.848
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.835
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.807
3gwf FADCyclohexanone monooxygenase / 0.807
2xve FADPutative flavin-containing monooxygenase / 0.769
2gv8 FADThiol-specific monooxygenase 1.14.13 0.754
2gvc FADThiol-specific monooxygenase 1.14.13 0.750
3mj4 FADUDP-galactopyranose mutase / 0.747
4aos FADSteroid monooxygenase / 0.734
3he3 FADUDP-galactopyranose mutase / 0.732
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.730
1y56 ATPUncharacterized protein / 0.723
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
2xls FADPutative flavin-containing monooxygenase / 0.720
2zbw FADFerredoxin--NADP reductase / 0.720
1n4v FADCholesterol oxidase 1.1.3.6 0.717
2jb1 FADL-amino acid oxidase / 0.716
4aox FADSteroid monooxygenase / 0.715
4eqr FADCoenzyme A disulfide reductase / 0.715
4b64 FADL-ornithine N(5)-monooxygenase / 0.714
3t2k FADSulfide-quinone reductase / 0.713
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.710
1yqz FADCoenzyme A disulfide reductase / 0.709
3ict FADCoenzyme A disulfide reductase / 0.709
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.708
4mo2 FADUDP-galactopyranose mutase / 0.707
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.706
2vqb FADPutative flavin-containing monooxygenase / 0.706
3b6d FAECholesterol oxidase 1.1.3.6 0.702
1cbo FADCholesterol oxidase 1.1.3.6 0.701
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.701
3ics FADCoenzyme A disulfide reductase / 0.701
3rha FDAPutrescine oxidase / 0.699
3icr FADCoenzyme A disulfide reductase / 0.697
4em3 FADCoenzyme A disulfide reductase / 0.697
4ap1 FADSteroid monooxygenase / 0.695
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.693
1f8r FADL-amino-acid oxidase 1.4.3.2 0.693
3sz0 FADSulfide-quinone reductase / 0.693
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.693
2xvf FADPutative flavin-containing monooxygenase / 0.692
4u2t FADCholesterol oxidase 1.1.3.6 0.692
1mxt FAECholesterol oxidase 1.1.3.6 0.690
4jq9 FADDihydrolipoyl dehydrogenase / 0.688
2xvh FADPutative flavin-containing monooxygenase / 0.687
3cox FADCholesterol oxidase 1.1.3.6 0.687
2gew FADCholesterol oxidase 1.1.3.6 0.686
3gyi FADCholesterol oxidase 1.1.3.6 0.686
4u2s FDACholesterol oxidase 1.1.3.6 0.686
4xwr FADCholesterol oxidase 1.1.3.6 0.686
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.684
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.684
3t14 FADSulfide-quinone reductase / 0.684
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.684
1cc2 FADCholesterol oxidase 1.1.3.6 0.683
1nhq FADNADH peroxidase 1.11.1.1 0.683
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.683
4jnq FDAThioredoxin reductase / 0.683
1tde FADThioredoxin reductase 1.8.1.9 0.682
2xlp FADPutative flavin-containing monooxygenase / 0.681
4qi5 FADCellobiose dehydrogenase / 0.681
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.680
4u8j FDAUDP-galactopyranose mutase / 0.676
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.675
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.675
5br7 FADUDP-galactopyranose mutase / 0.674
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.673
5cku FADL-ornithine N(5)-monooxygenase / 0.673
1c0l FADD-amino-acid oxidase 1.4.3.3 0.672
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.672
3f8p NADNADH oxidase/thioredoxin reductase / 0.672
2ptf FMNUncharacterized protein MTH_863 / 0.671
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.670
2r0c FADPutative FAD-monooxygenase / 0.670
3pl8 FADPyranose 2-oxidase / 0.670
4ap3 FADSteroid monooxygenase / 0.670
4u2l SFDCholesterol oxidase 1.1.3.6 0.670
3t2y FADSulfide-quinone reductase / 0.669
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.669
1n4u FAECholesterol oxidase 1.1.3.6 0.668
2xvi FADPutative flavin-containing monooxygenase / 0.668
3cnj FADCholesterol oxidase 1.1.3.6 0.668
3syi FADSulfide-quinone reductase / 0.668
4rek FADCholesterol oxidase 1.1.3.6 0.668
2r9z FADGlutathione amide reductase / 0.667
3zdn FADMonoamine oxidase N 1.4.3.4 0.667
4b66 FADL-ornithine N(5)-monooxygenase / 0.667
4qi4 FADCellobiose dehydrogenase / 0.667
4u8p FDAUDP-galactopyranose mutase / 0.667
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.667
1ng3 FADGlycine oxidase 1.4.3.19 0.666
3k30 ADPHistamine dehydrogenase / 0.666
3ukf FDAUDP-galactopyranose mutase / 0.666
2eq7 NADDihydrolipoyl dehydrogenase / 0.665
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.664
3lsi FADPyranose 2-oxidase / 0.664
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.663
3w2f FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.663
3kpk FADSulfide-quinone reductase / 0.662
1t6z RBFRiboflavin biosynthesis protein / 0.661
1npx FADNADH peroxidase 1.11.1.1 0.660
1b8s FADCholesterol oxidase 1.1.3.6 0.659
4cnk FADL-amino acid oxidase / 0.659
1gal FADGlucose oxidase 1.1.3.4 0.657
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.657
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.656
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.656
2pr5 FMNBlue-light photoreceptor / 0.656
1ylr FMNOxygen-insensitive NAD(P)H nitroreductase / 0.654
2i51 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.654
3of4 FMNNitroreductase / 0.654
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.653
1ndh FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.653
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.653
4b69 FADL-ornithine N(5)-monooxygenase / 0.653
4fwe FADLysine-specific histone demethylase 1B 1 0.653
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.653
1usc FMNMonooxygenase / 0.652
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.652
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.652
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.651
1tdf FADThioredoxin reductase 1.8.1.9 0.651
2xlr FADPutative flavin-containing monooxygenase / 0.651
3cgb FADCoenzyme A disulfide reductase / 0.651
3nlc FADUncharacterized protein / 0.651
1n07 FMNRiboflavin kinase 2.7.1.26 0.650
1n1p FADCholesterol oxidase 1.1.3.6 0.650