Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tri NAP Pyrroline-5-carboxylate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3tri NAPPyrroline-5-carboxylate reductase / 1.381
5bsg NAPPyrroline-5-carboxylate reductase / 0.789
2rcy NAPPyrroline-5-carboxylate reductase / 0.776
3m2t NADProbable dehydrogenase / 0.769
3ec7 NADInositol 2-dehydrogenase / 0.757
2ahr NAPPyrroline-5-carboxylate reductase / 0.749
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.735
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.733
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.723
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.722
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.721
3ikt NADRedox-sensing transcriptional repressor Rex / 0.720
1zh8 NAPUncharacterized protein / 0.719
2voj NADAlanine dehydrogenase 1.4.1.1 0.718
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.717
3v1y NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.717
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.716
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.714
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.712
3ggp NADPrephenate dehydrogenase / 0.711
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.710
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.710
3hwr NDP2-dehydropantoate 2-reductase / 0.710
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.708
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.708
4dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.707
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.706
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.703
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.701
2x0i NAIMalate dehydrogenase / 0.700
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.700
3abi NADUncharacterized protein / 0.699
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.698
1uxj NADMalate dehydrogenase / 0.698
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.698
3adp NAILambda-crystallin 1.1.1.45 0.698
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.697
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.696
3keo NADRedox-sensing transcriptional repressor Rex / 0.695
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.694
1nbo NADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.694
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.694
2jkv NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.693
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.693
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.690
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.689
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.689
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.688
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.686
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.685
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.685
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.685
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.685
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.684
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.684
2vq3 NAPMetalloreductase STEAP3 / 0.683
3hja NADGlyceraldehyde-3-phosphate dehydrogenase / 0.683
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.682
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.682
4xb2 NDP319aa long hypothetical homoserine dehydrogenase / 0.682
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.681
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.680
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.680
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.679
3x2f NAIAdenosylhomocysteinase / 0.679
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.678
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.677
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.677
5a05 NDPGlucose-fructose oxidoreductase / 0.676
5bsf NADPyrroline-5-carboxylate reductase / 0.676
2glx NDP1,5-anhydro-D-fructose reductase / 0.675
2vhx NADAlanine dehydrogenase 1.4.1.1 0.675
2d2i NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.674
4z0h NADGlyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic 1.2.1.12 0.674
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.673
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.673
2dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.672
5a9s NAPPutative dehydrogenase / 0.672
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.671
3d3w NAPL-xylulose reductase 1.1.1.10 0.671
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.671
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.671
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.671
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.670
3t4e NADQuinate/shikimate dehydrogenase / 0.670
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.668
2o4c NADErythronate-4-phosphate dehydrogenase / 0.667
3ggo NAIPrephenate dehydrogenase / 0.667
2jae FADL-amino acid oxidase / 0.666
2pv7 NADT-protein 1.3.1.12 0.666
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.666
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.666
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.665
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.665
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.665
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.665
2bd0 NAPSepiapterin reductase / 0.664
2yjz NAPMetalloreductase STEAP4 1.16.1 0.664
3ntr NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.664
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.663
3q2k NAIProbable oxidoreductase / 0.663
4yac NAIC alpha-dehydrogenase / 0.663
1c1d NAIPhenylalanine dehydrogenase / 0.662
1uxk NADMalate dehydrogenase / 0.662
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.662
4rtr SAMDNA adenine methylase 2.1.1.72 0.662
2z1m NDPGDP-mannose 4,6-dehydratase / 0.661
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.660
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.660
1o6z NADMalate dehydrogenase / 0.660
3b20 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.660
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.660
5a06 NDPGlucose-fructose oxidoreductase / 0.660
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.659
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.659
4tm3 FADKtzI / 0.659
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.658
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.658
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.657
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.656
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.656
1rm3 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.656
1rm4 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.656
1ywg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.656
2pr5 FMNBlue-light photoreceptor / 0.656
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.656
4nec SAHPutative SAM-dependent methyltransferase / 0.656
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.655
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.655
4dpl NAPMalonyl-CoA reductase 1.2.1.75 0.655
4xr9 NADCalS8 / 0.655
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.654
1f8f NADBenzyl alcohol dehydrogenase / 0.654
1guy NADMalate dehydrogenase / 0.654
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.654
2czc NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.59 0.654
3ajr NADNDP-sugar epimerase / 0.654
3jv7 NADSecondary alcohol dehydrogenase / 0.654
3ksd NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.654
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.653
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.653
4hb9 FADUncharacterized protein / 0.653
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.652
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.652
1qmg APXKetol-acid reductoisomerase, chloroplastic 1.1.1.86 0.652
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.652
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.652
3wv7 ADPHmd co-occurring protein HcgE / 0.652
1npd NADQuinate/shikimate dehydrogenase / 0.651
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.651
4ejm NAPPutative zinc-binding dehydrogenase / 0.651
4gdp FADPolyamine oxidase FMS1 / 0.651
4xgi NADGlutamate dehydrogenase / 0.651
4xyb NDPFormate dehydrogenase / 0.651
2ag8 NAPPyrroline-5-carboxylate reductase / 0.650
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.650
3keq NADRedox-sensing transcriptional repressor Rex / 0.650
3o26 NDPSalutaridine reductase / 0.650