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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rhq NAP Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.320
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.309
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.266
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.256
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.238
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.189
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.019
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.976
4i8p NADAminoaldehyde dehydrogenase 1 / 0.936
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.929
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.921
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.916
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.915
4pz2 NADAldehyde dehydrogenase 2-6 / 0.907
3b4w NADAldehyde dehydrogenase family protein / 0.902
4i8q NADPutative betaine aldehyde dehyrogenase / 0.895
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.891
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.884
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.881
2jg7 NADAntiquitin / 0.872
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.858
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.851
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.842
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.842
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.841
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.829
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.828
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.828
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.824
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.817
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.815
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.805
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.805
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.800
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.794
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.792
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.781
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.774
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.772
4pt0 NADAldehyde dehydrogenase / 0.772
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.770
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.756
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.751
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.751
4pxl NADAldehyde dehydrogenase3 / 0.744
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.741
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.741
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.739
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.739
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.739
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.739
3haz NADBifunctional protein PutA / 0.739
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.733
4i3w NADAldehyde dehydrogenase (NAD+) / 0.730
4i3v NADAldehyde dehydrogenase (NAD+) / 0.727
4c3s NADAldehyde Dehydrogenase / 0.723
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.722
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.722
4f3x NADPutative aldehyde dehydrogenase / 0.721
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.719
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.718
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.715
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.714
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.713
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.712
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.712
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.711
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.710
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.708
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.708
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.702
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.702
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.702
4i9b NADPutative betaine aldehyde dehyrogenase / 0.701
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.699
4nmk NAPAldehyde dehydrogenase / 0.698
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.697
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.691
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.691
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.689
4h73 NDPAldehyde dehydrogenase / 0.684
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.681
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.678
5dib NADBetaine-aldehyde dehydrogenase / 0.677
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.675
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.670
4l2o NADAldehyde dehydrogenase, dimeric NADP-preferring / 0.665
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.662
2voj NADAlanine dehydrogenase 1.4.1.1 0.657
4pt3 NDPAldehyde dehydrogenase / 0.655
1m8j NADNicotinamide-nucleotide adenylyltransferase 2.7.7.1 0.652
2y53 NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.650