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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rhj NAP Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.338
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.258
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.253
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.238
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.204
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.191
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.038
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.962
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.950
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.947
4pz2 NADAldehyde dehydrogenase 2-6 / 0.946
4i8q NADPutative betaine aldehyde dehyrogenase / 0.924
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.921
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.918
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.917
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.906
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.904
3b4w NADAldehyde dehydrogenase family protein / 0.904
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.896
2jg7 NADAntiquitin / 0.885
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.884
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.883
4i8p NADAminoaldehyde dehydrogenase 1 / 0.883
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.876
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.874
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.845
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.842
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.842
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.842
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.838
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.836
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.831
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.828
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.824
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.816
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.795
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.791
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.775
3haz NADBifunctional protein PutA / 0.761
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.760
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.760
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.759
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.757
4pt0 NADAldehyde dehydrogenase / 0.757
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.754
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.754
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.754
4pxl NADAldehyde dehydrogenase3 / 0.751
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.750
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.750
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.749
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.744
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.739
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.739
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.735
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.731
4i3w NADAldehyde dehydrogenase (NAD+) / 0.730
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.724
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.723
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.720
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.720
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.719
4f3x NADPutative aldehyde dehydrogenase / 0.719
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.718
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.718
4i3v NADAldehyde dehydrogenase (NAD+) / 0.712
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.712
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.706
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.704
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.703
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.702
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.702
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.702
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.697
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.690
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.682
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.680
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.679
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.669
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.669
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.667
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.667
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.659
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.658
1bi9 NADRetinal dehydrogenase 2 / 0.656
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.655