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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nt2 NAD Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 1.004
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.810
3ec7 NADInositol 2-dehydrogenase / 0.790
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.749
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.736
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.735
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.732
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.731
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.730
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.728
4l8v NAPInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.727
2g5c NADPrephenate dehydrogenase / 0.726
3ntq NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.726
3q2k NAIProbable oxidoreductase / 0.725
2voj NADAlanine dehydrogenase 1.4.1.1 0.724
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.717
4c4o NADSADH / 0.713
3adp NAILambda-crystallin 1.1.1.45 0.711
3m2t NADProbable dehydrogenase / 0.710
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.709
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.701
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.701
3tri NAPPyrroline-5-carboxylate reductase / 0.700
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.699
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.699
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.699
3ikt NADRedox-sensing transcriptional repressor Rex / 0.698
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.695
3jv7 NADSecondary alcohol dehydrogenase / 0.695
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.692
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.692
1ib6 NADMalate dehydrogenase / 0.691
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.690
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.689
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.689
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.689
1c1d NAIPhenylalanine dehydrogenase / 0.686
1zmd NAIDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.686
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.686
2vhx NADAlanine dehydrogenase 1.4.1.1 0.686
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.685
4xgi NADGlutamate dehydrogenase / 0.684
3f3s NADLambda-crystallin homolog / 0.683
4j4b NAIUncharacterized protein / 0.683
3ntr NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.680
5a02 NAPGlucose-fructose oxidoreductase / 0.680
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.679
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 0.679
1zh8 NAPUncharacterized protein / 0.679
3q3c NADNAD-dependent L-serine dehydrogenase / 0.679
5bsg NAPPyrroline-5-carboxylate reductase / 0.679
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.678
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.678
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.678
3ket NADRedox-sensing transcriptional repressor Rex / 0.678
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.677
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.676
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.676
5a06 NDPGlucose-fructose oxidoreductase / 0.676
5a04 NDPGlucose-fructose oxidoreductase / 0.675
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.674
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.674
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.674
2x0i NAIMalate dehydrogenase / 0.674
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.674
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.673
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.672
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.671
3hja NADGlyceraldehyde-3-phosphate dehydrogenase / 0.671
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.670
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.670
2yut NAPPutative short-chain oxidoreductase / 0.670
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.670
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.670
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.669
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.669
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.668
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.668
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.668
3ggo NAIPrephenate dehydrogenase / 0.668
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.667
3nt2 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.667
4j49 NADUncharacterized protein / 0.667
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.667
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.666
2rgj FADFlavin-containing monooxygenase / 0.666
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.664
4lcj NADC-terminal-binding protein 2 / 0.664
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.663
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.663
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.663
4jk3 NADUncharacterized protein / 0.663
5a05 NDPGlucose-fructose oxidoreductase / 0.663
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.662
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.662
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.662
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.662
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.662
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.662
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.661
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.661
5a03 NDPGlucose-fructose oxidoreductase / 0.661
1gae NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.660
3ing NDPHomoserine dehydrogenase related protein / 0.660
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.660
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.660
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.659
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.658
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
2fkn NADUrocanate hydratase 4.2.1.49 0.658
2o4c NADErythronate-4-phosphate dehydrogenase / 0.658
2yjz NAPMetalloreductase STEAP4 1.16.1 0.658
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.657
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.657
2f1k NAPPrephenate dehydrogenase / 0.656
2x0r NADMalate dehydrogenase / 0.656
3d64 NADAdenosylhomocysteinase / 0.656
1llq NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.655
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.655
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.654
1zem NADXylitol dehydrogenase / 0.654
3keo NADRedox-sensing transcriptional repressor Rex / 0.654
4egb NADdTDP-glucose 4,6-dehydratase / 0.654
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.654
3aw9 NADNAD-dependent epimerase/dehydratase / 0.653
4j43 NADUncharacterized protein / 0.653
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.653
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.653
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.652
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.652
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.652
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.651
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.651